ArticleJournal of biomechanics2018
A magnetic resonance imaging framework for quantifying intervertebral disc deformation in vivo: Reliability and application to diurnal variations in lumbar disc shape.
Article in Journal of biomechanics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 25 citations in OpenAlex.
- Human In Vivo Disc Mechanics in Flexion, Extension, and Diurnal Loading With Aging and Degeneration.JOR spine · 2026Article
- Degeneration-Driven and Load-Modulated Fluid-Driven Viscoelasticity of the Human Intervertebral Disc: A Probabilistic Biphasic Swelling Modeling Study.Bioengineering (Basel, Switzerland) · 2026Article
- Complex Mechanical Loading and Pro-Inflammatory Cytokines in Intervertebral Disc Degeneration.JOR spine · 2026Article
- The effect of spaceflight on tissues of the spinal column.Bone reports · 2026Review
- Advances in mechanical assessments of in vivo human lumbar spine tissues with noninvasive imaging techniques.npj biomedical innovations · 2026Review
- Article
- Resting Supine for 45 Minutes Yields Consistent Baseline Lumbar Intervertebral Disc Height in Asymptomatic Participants.Annals of biomedical engineering · 2025Article
- Age and gender differences in lumbar intervertebral disk strain using mechanical loading magnetic resonance imaging.NMR in biomedicine · 2023Article
- MRI-based measurement of in vivo disc mechanics in a young population due to flexion, extension, and diurnal loading.JOR spine · 2023Article
- In vivo intervertebral disc mechanical deformation following a treadmill walking "stress test" is inversely related to T1rho relaxation time.Osteoarthritis and cartilage · 2023Article
- Disc geometry measurement methods affect reported compressive mechanics by up to 65.JOR spine · 2022Article
- In vivo fluid transport in human intervertebral discs varies by spinal level and disc region.JOR spine · 2022Article
- Lumbar intervertebral disc diurnal deformations and T2 and T1rho relaxation times vary by spinal level and disc region.European spine journal : official publication of the European Spine Society, the European Spinal Deformity Society, and the European Section of the Cervical Spine Research Society · 2022Article
- In Situ Cell Signalling of the Hippo-YAP/TAZ Pathway in Reaction to Complex Dynamic Loading in an Intervertebral Disc Organ Culture.International journal of molecular sciences · 2021Article
- In vivo relationships between lumbar facet joint and intervertebral disc composition and diurnal deformation.Clinical biomechanics (Bristol, Avon) · 2021Article
- Increasing BMI increases lumbar intervertebral disc deformation following a treadmill walking stress test.Journal of biomechanics · 2021Article
- Spine biomechanical testing methodologies: The controversy of consensus vs scientific evidence.JOR spine · 2021Review
- In vivo intervertebral disc deformation: intratissue strain patterns within adjacent discs during flexion-extension.Scientific reports · 2021Article
- Different Phenotypes of Osteoarthritis in the Lumbar Spine Reflected by Demographic and Clinical Characteristics: The Johnston County Osteoarthritis Project.Arthritis care & research · 2020Article
- Activities of daily living influence tibial cartilage T1rho relaxation times.Journal of biomechanics · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Low back pain is a significant socioeconomic burden in the United States and lumbar intervertebral disc degeneration is frequently implicated as a cause. The discs play an important mechanical role in the spine, yet the relationship between disc function and back pain is poorly defined. The objective of this work was to develop a technique using magnetic resonance imaging (MRI) and three-dimensional modeling to measure in vivo disc deformations. Using this method, we found that disc geometry was measurable with precision less than the in-plane dimensions of a voxel (≈100 µm, 10% of the MRI pixel size). Furthermore, there was excellent agreement between mean disc height, disc perimeter, disc volume and regional disc height measurements for multiple trials from an individual rater (standard deviation <3.1% across all measurements) and between mean height, perimeter, and volume measurements made by two independent raters (error <1.5% across all measurements). We then used this measurement system to track diurnal deformations in the L5-S1 disc in a young, healthy population (n = 8; age 24.1 ± 3.3 yrs; 2 M/6F). We measured decreases in the mean disc height (-8%) and volume (-9%) with no changes in perimeter over an eight-hour workday. We found that the largest height losses occurred in the posterior (-13%) and posterior-lateral (-14%) regions adjacent to the outer annulus fibrosus. Diurnal annulus fibrosus (AF) strains induced by posterior and posterior-lateral height loss may increase the risk for posterior disc herniation or posterior AF tears. These preliminary findings lay a foundation for determining how deviations from normal deformations may contribute to back pain.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.