Trial reportEuropean journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society2018
Transcranial direct current stimulation and constraint-induced therapy in cerebral palsy: A randomized, blinded, sham-controlled clinical trial.
Trial report in European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT03635775 (Effects of Single-session Transcranial Direct Current Stimulation in Children With Cerebral Palsy), which is not on this map. Cited by 42 papers, 4 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Effects of Single-session Transcranial Direct Current Stimulation in Children With Cerebral Palsy
Who cites it
42 citing papers in PubMed, 4 syntheses or guidelines pooled it, 76 citations in OpenAlex.
- Pooled it
- Noninvasive brain stimulation for upper limb motor activity in children and young adults with cerebral palsy and pediatric stroke: a systematic review and meta-analysis.Journal of neuroengineering and rehabilitation · 2025Pooled it
- Constraint-induced movement therapy in children with unilateral cerebral palsy.The Cochrane database of systematic reviews · 2019Pooled it
- Transcranial Direct Current Stimulation in Pediatric Motor Disorders: A Systematic Review and Meta-analysis.Archives of physical medicine and rehabilitation · 2019Pooled it
- Safety and feasibility of transcranial direct current stimulation stratified by corticospinal organization in children with hemiparesis.European journal of paediatric neurology : EJPN : official journal of the European Paediatric Neurology Society · 2023Trial
- Transcranial Direct Current Stimulation (tDCS) in Unilateral Cerebral Palsy: A Pilot Study of Motor Effect.Neural plasticity · 2019Trial
- Electrotherapy in Pediatric Rehabilitation: A Structured Narrative Review of Clinical Applications, Treatment Parameters, Safety, and Evidence Gaps.Journal of clinical medicine · 2026Review
- Electroacupuncture combined with rTMS promotes neuronal regenerationEuropean journal of histochemistry : EJH · 2026Article
- Effectiveness of Electrical Stimulation on Upper Limb Function in Children and Young People with Hemiplegic Cerebral Palsy: A Systematic Review.Journal of clinical medicine · 2025Review
- Non-invasive brain stimulation for upper extremity dysfunction in children with cerebral palsy: a systematic review and meta-analysis.Translational pediatrics · 2025Article
- TOPSS: TOlerability of transcranial direct current stimulation in Pediatric Stroke Survivors.Frontiers in human neuroscience · 2025Article
- Article
- Single-pulse transcranial magnetic stimulation for assessment of motor development in infants with early brain injury.Expert review of medical devices · 2024Article
- The Effect of Transcranial Direct Current Stimulation on M1 with and without Mirror Visual Feedback on Range of Motion and Hand Grip Strength of the Affected Upper Limb in Children with Spastic Hemiplegic Cerebral Palsy.Iranian journal of child neurology · 2024Article
- An analysis of stimulation methods used in rehabilitation equipment for children with cerebral palsy.Frontiers in neurology · 2024Review
- Anodal Contralesional tDCS Enhances CST Excitability Bilaterally in an Adolescent with Hemiparetic Cerebral Palsy: A Brief Report.Developmental neurorehabilitation · 2023Article
- Neurotechnology and Noninvasive Neuromodulation: Case Study for Understanding and Anticipating Emerging Science and Technology.NAM perspectives · 2023Review
- Neuromotor Rehabilitation Interventions After Pediatric Stroke: A Focused Review.Seminars in pediatric neurology · 2022Review
- Remotely monitored transcranial direct current stimulation in pediatric cerebral palsy: open label trial protocol.BMC pediatrics · 2022Article
- Robotic mapping of motor cortex in children with perinatal stroke and hemiparesis.Human brain mapping · 2022Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
12 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the safety, feasibility, and efficacy of transcranial direct current stimulation (tDCS) combined with constraint-induced movement therapy (CIMT) in children and young adults with unilateral cerebral palsy. Twenty participants were randomized to receive active or sham tDCS. The intervention consisted of 10 consecutive weekday sessions of tDCS applied to the non-lesioned hemisphere (20 min) concurrently with CIMT (120 min). Participants, caregivers, and interventionists were blinded to group assignment. The primary safety outcome investigated adverse events. The primary behavioral outcome was the Assisting Hand Assessment. All 20 participants (mean age = 12.7 yrs, range = 7.4-21.6 years) were evaluated for the primary outcomes. No serious adverse events occurred, and the most commonly reported minor adverse events were headache and itchiness. Both groups demonstrated a significant improvement in hand function after the intervention, although no significant effect of tDCS was observed (between-group difference = -2.18, 95% CI = [-6.48, 2.12], p = 0.30). Although hand function improved overall, no significant differences between intervention groups were found. Children with preserved corticospinal tract circuitry from the lesioned hemisphere, compared to those without, showed greater improvement in hand function (mean difference = 3.04, 95% CI = [-0.64, 6.72], p = 0.099). Our study demonstrates the safety and feasibility of serial sessions of tDCS, and presents preliminary evidence for the effect of CST circuitry on outcomes following tDCS/CIMT. Future work in children with unilateral cerebral palsy should focus on the optimal dosing and consider individual brain circuitry when describing response to combined interventions. CLINICAL TRIALS REGISTRATION: Clinicaltrials.govNCT 02250092.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.