Evidence map›Paper›PMID 29455858›Full record

ArticleAmerican journal of human genetics2018

A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure.

Yun J Sung, Thomas W Winkler, Lisa de las Fuentes, Amy R Bentley, Michael R Brown, Aldi T Kraja, Karen Schwander, Ioanna Ntalla, Xiuqing Guo, Nora Franceschini and 291 more

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in American journal of human genetics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 108 papers, 12 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
108citing papers in PubMed, 12 pooled it
13.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

108 citing papers in PubMed, 12 syntheses or guidelines pooled it, 176 citations in OpenAlex.

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  19. Hypothesis test of specific parametric structure in a generalized additive model.medRxiv : the preprint server for health sciences · 2025
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48 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

301 authors at 20 institutions in 24 countries.

Yun J SungDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA. Electronic address: yunju@wustl.edu.
Thomas W WinklerDepartment of Genetic Epidemiology, University of Regensburg, Regensburg 93051, Germany.
Lisa de las FuentesCardiovascular Division, Department of Medicine, Washington University, St. Louis, MO 63110, USA.
Amy R BentleyCenter for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Michael R BrownDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA.
Aldi T KrajaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Karen SchwanderDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Ioanna NtallaWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK.
Xiuqing GuoGenomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Nora FranceschiniDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA.
Yingchang LuIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA.
Ching-Yu ChengSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore.
Xueling SimSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore.
Dina VojinovicDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Jonathan MartenMedical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Solomon K MusaniJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA.
Changwei LiDepartment of Epidemiology and Biostatistics, University of Giorgia at Athens College of Public Health, Athens, GA 30602, USA.
Mary F FeitosaDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Tuomas O KilpeläinenSection of Metabolic Genetics, Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen 2100, Denmark; Department of Environmental Medicine and Public Health, The Icahn School of Medicine at Mount Sinai, New York, NY 10029, USA.
Melissa A RichardBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Raymond NoordamDepartment of Internal Medicine, Section of Gerontology and Geriatrics, Leiden University Medical Center, Leiden 2300RC, the Netherlands.
Stella AslibekyanDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Hugues AschardDepartment of Epidemiology, Harvard School of Public Health, Boston, MA 02115, USA; Centre de Bioinformatique Biostatistique et Biologie Integrative (C3BI), Institut Pasteur, Paris 75015, France.
Traci M BartzCardiovascular Health Research Unit, Biostatistics and Medicine, University of Washington, Seattle, WA 98101, USA.
Rajkumar DorajooGenome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore.
Yongmei LiuDivision of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Alisa K ManningCenter for Human Genetics Research, Massachusetts General Hospital, Boston, MA 02114, USA; Program in Medical and Population Genetics, Broad Institute of MIT and Harvard, Cambridge, MA 02142, USA.
Tuomo RankinenHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Albert Vernon SmithIcelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
Salman M TajuddinHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Bamidele O TayoDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA.
Helen R WarrenWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Wei ZhaoSchool of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Yanhua ZhouDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Nana MatobaLaboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
Tamar SoferDepartment of Biostatistics, University of Washington, Seattle, WA 98105, USA.
Maris AlverEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Marzyeh AminiDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Mathilde BoisselCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France.
Jin Fang ChaiSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore.
Xu ChenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Jasmin DiversDivision of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Ilaria GandinDepartment of Medical Sciences, University of Trieste, Trieste 34137, Italy.
Chuan GaoDepartment of Molecular Genetics and Genomics Program, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Franco GiulianiniDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Anuj GoelDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Sarah E HarrisCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Medical Genetics Section, University of Edinburgh Centre for Genomic and Experimental Medicine and MRC Institute of Genetics and Molecular Medicine, The University of Edinburgh, Edinburgh EH4 2XU, UK.
Fernando Pires HartwigPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, Brazil.
Andrea R V R HorimotoLab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil.
Fang-Chi HsuDivision of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Anne U JacksonDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Mika KähönenDepartment of Clinical Physiology, Faculty of Medicine and Life Sciences, University of Tampere, Tampere 33014, Finland; Department of Clinical Physiology, Tampere University Hospital, Tampere, Finland.
Anuradhani KasturiratneDepartment of Public Health, University of Kelaniya, Ragama, Sri Lanka.
Brigitte KühnelResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Karin LeanderInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden.
Wen-Jane LeeDepartment of Medical Research, Taichung Veterans General Hospital, Department of Social Work, Tunghai University, Taichung 40705, Taiwan.
Keng-Hung LinDepartment of Opthalmology, Taichung Veterans General Hospital, Taichung 40705, Taiwan.
Jian 'an LuanMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Colin A McKenzieTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
He MeianDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.
Christopher P NelsonDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Rainer RauramaaFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, Finland.
Nicole SchupfTaub Institute for Research on Alzheimer disease and the Aging Brain, Department of Epidemiology, Columbia University Mailman School of Public Health, New York, NY 10032, USA.
Robert A ScottMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Wayne H H SheuEndocrinology and Metabolism, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung 40705, Taiwan; School of Medicine, National Yang-ming University, Taipei, Taiwan; School of Medicine, National Defense Medical Center, Taipei, Taiwan; Institute of Medical Technology, National Chung-Hsing University, Taichung 40705, Taiwan.
Alena StančákováInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland, Kuopio 70210, Finland.
Fumihiko TakeuchiDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, Japan.
Peter J van der MostDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Tibor V VargaGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden.
Heming WangDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
Yajuan WangDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
Erin B WareSchool of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA; Institute for Social Research, Research Center for Group Dynamics, University of Michigan, Ann Arbor, MI 48104, USA.
Stefan WeissInterfaculty Institute for Genetics and Functional Genomics, University Medicine and Ernst-Moritz Arndt University Greifswald, Greifswald 17487, Germany; DZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany.
Wanqing WenDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Lisa R YanekGeneral Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Weihua ZhangDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK.
Jing Hua ZhaoMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Saima AfaqDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Tamuno AlfredIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA.
Najaf AminDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Dan ArkingMcKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
Tin AungSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore.
R Graham BarrDepartments of Medicine and Epidemiology, Columbia University Medical Center, New York, NY 10032, USA.
Lawrence F BielakSchool of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Eric BoerwinkleHuman Genetics Center, The University of Texas School of Public Health, Houston, TX 77030, USA; Institute of Molecular Medicine, The University of Texas Health Science Center, Houston, TX 77030, USA.
Erwin P BottingerIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA.
Peter S BraundDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
Jennifer A BrodyCardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USA.
Ulrich BroeckelSection of Genomic Pediatrics, Department of Pediatrics, Medicine and Physiology, Medical College of Wisconsin, Milwaukee, WI 53226, USA.
Claudia P CabreraWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Brian CadeSleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.
Yu CaizhengDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.
Archie CampbellCentre for Genomic & Experimental Medicine, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Mickaël CanouilCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France.
Aravinda ChakravartiCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
CHARGE Neurology Working Group
Ganesh ChauhanCentre for Brain Research, Indian Institute of Schience, Bangalore 560012, India.
Kaare ChristensenThe Danish Aging Research Center, Institute of Public Health, University of Southern Denmark, Odense, Denmark.
Massimiliano CoccaDepartment of Medical Sciences, University of Trieste, Trieste 34137, Italy.
COGENT-Kidney Consortium
Francis S CollinsMedical Genomics and Metabolic Genetics Branch, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
John M ConnellNinewells Hospital & Medical School, University of Dundee, Dundee DD1 9SY, UK.
Renée de MutsertDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the Netherlands.
H Janaka de SilvaDepartment of Medicine, University of Kelaniya, Ragama, Sri Lanka.
Stephanie DebetteInserm U1219 Neuroepidemiology, University of Bordeaux, Bordeaux, France; Department of Neurology, University Hospital, Bordeaux, France; Boston University School of Medicine, Boston, MA 02118, USA.
Marcus DörrDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Department of Internal Medicine B, University Medicine Greifswald, Greifswald 17475, Germany.
Qing DuanDepartment of Genetics, University of North Carolina, Chapel Hill, NC 27514, USA.
Charles B EatonDepartment of Family Medicine and Epidemiology, Alpert Medical School of Brown University, Providence, RI 02860, USA.
Georg EhretCenter for Complex Disease Genomics, McKusick-Nathans Institute of Genetic Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA; Division of Cardiology, Department of Specialties of Medicine, Geneva University Hospital, Geneva 1211, Switzerland.
Evangelos EvangelouDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Hygiene and Epidemiology, University of Ioannina Medical School, Ioannina 45110, Greece.
Jessica D FaulInstitute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA.
Virginia A FisherDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Nita G ForouhiMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Oscar H FrancoDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Yechiel FriedlanderBraun School of Public Health, Hebrew University-Hadassah Medical Center, Jerusalem 91120, Israel.
He GaoDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK.
GIANT Consortium
Bruna GiganteInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden.
Misa GraffDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA.
C Charles GuDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Dongfeng GuDepartment of Epidemiology, State Key Laboratory of Cardiovascular Disease, Fuwai Hospital, National Center for Cardiovascular Diseases, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China.
Preeti GuptaSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore.
Saskia P HagenaarsCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK.
Tamara B HarrisLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
Jiang HeDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA; Department of Medicine, Tulane University School of Medicine, New Orleans, LA 70112, USA.
Sami HeikkinenUniversity of Eastern Finland, Institute of Biomedicine, Kuopio 70211, Finland.
Chew-Kiat HengDepartment of Paediatrics, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore; Khoo Teck Puat - National University Children's Medical Institute, National University Health System, Singapore 119228, Singapore.
Makoto HirataLaboratory of Genome Technology, Human Genome Center, Institute of Medical Science, The University of Tokyo, Minato-ku 108-8639, Japan.
Albert HofmanDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
Barbara V HowardMedStar Health Research Institute, Hyattsville, MD 20782, USA; Center for Clinical and Translational Sciences and Department of Medicine, Georgetown-Howard Universities, Washington, DC 20057, USA.
Steven HuntCardiovascular Genetics, Department of Internal Medicine, University of Utah, Salt Lake City, UT 84108, USA; Weill Cornell Medicine in Qatar, Doha, Qatar.
Marguerite R IrvinDepartment of Epidemiology, University of Alabama at Birmingham, Birmingham, AL 35294, USA.
Yucheng JiaGenomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Roby JoehanesHebrew SeniorLife, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02131, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA.
Anne E JusticeDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA.
Tomohiro KatsuyaDepartment of Clinical Gene Therapy, Osaka University Graduate School of Medicine, Suita 5650871, Japan; Department of Geriatric and General Medicine, Osaka University Graduate School of Medicine, Suita 5650871, Japan.
Joel KaufmanEpidemiology, Department of Occupational and Environmental Medicine Program, University of Washington, Seattle, WA 98105, USA.
Nicola D KerrisonMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Chiea Chuen KhorGenome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore; Department of Biochemistry, National University of Singapore, Singapore 117596, Singapore.
Woon-Puay KohSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore; Duke-NUS Medical School, Singapore 169857, Singapore.
Heikki A KoistinenDepartment of Health, National Institute for Health and Welfare, Helsinki 00271, Finland; Department of Medicine and Abdominal Center: Endocrinology, University of Helsinki and Helsinki University Central Hospital, Helsinki 00029, Finland.
Pirjo KomulainenFoundation for Research in Health Exercise and Nutrition, Kuopio Research Institute of Exercise Medicine, Kuopio 70100, Finland.
Charles KooperbergFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USA.
Jose E KriegerLab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil.
Michiaki KuboCenter for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
Johanna KuusistoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
Carl D LangefeldDivision of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Claudia LangenbergMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Lenore J LaunerLaboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Bethesda, MD 20892, USA.
Benjamin LehneDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK.
Cora E LewisDepartment of Medicine, University of Alabama at Birmingham, Birmingham, AL 35205, USA.
Yize LiDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Lifelines Cohort StudyLifelines cohort study, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Sing Hui LimSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore.
Shiow LinDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Ching-Ti LiuDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA.
Jianjun LiuSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore.
Jingmin LiuWHI CCC, Fred Hutchinson Cancer Research Center, Seattle, WA 98115, USA.
Kiang LiuPreventive Medicine, Northwestern University Feinberg School of Medicine, Chicago, IL 60611, USA.
Yeheng LiuGenomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Marie LohDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Translational Laboratory in Genetic Medicine, Agency for Science, Technology and Research 138648, Singapore.
Kurt K LohmanDivision of Biostatistical Sciences, Department of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Jirong LongDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Tin LouieDepartment of Biostatistics, University of Washington, Seattle, WA 98105, USA.
Reedik MägiEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Anubha MahajanWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Thomas MeitingerInstitute of Human Genetics, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Human Genetics, Technische Universität München, Munich 80333, Germany.
Andres MetspaluEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Lili MilaniEstonian Genome Center, University of Tartu, Tartu 51010, Estonia.
Yukihide MomozawaLaboratory for Genotyping Development, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
Andrew P MorrisWellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK; Department of Biostatistics, University of Liverpool, Liverpool L69 3GL, UK.
Thomas H MosleyGeriatrics, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Peter MunsonMathematical and Statistical Computing Laboratory, Center for Information Technology, NIH, Bethesda, MD 20892, USA.
Alison D MurrayThe Institute of Medical Sciences, Aberdeen Biomedical Imaging Centre, University of Aberdeen, Aberdeen AB25 2ZD, UK.
Mike A NallsData Tecnica International, Glen Echo, MD 20812, USA; Laboratory of Neurogenetics, National Institute on Aging, Bethesda, MD 20892, USA.
Ubaydah NasriGenomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Jill M NorrisDepartment of Epidemiology, Colorado School of Public Health, Aurora, CO 80045, USA.
Kari NorthDepartment of Epidemiology, University of North Carolina Gillings School of Global Public Health, Chapel Hill, NC 27514, USA.
Adesola OgunniyiDepartment of Medicine, University of Ibadan, Ibadan, Nigeria.
Sandosh PadmanabhanInstitute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow G12 8TA, UK.
Walter R PalmasInternal Medicine, Department of Medicine, Columbia University, New York, NY 10032, USA.
Nicholette D PalmerDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
James S PankowDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA.
Nancy L PedersenDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Annette PetersInstitute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; DZHK (German Centre for Cardiovascular Research), partner site Munich Heart Alliance, Neuherberg 85764, Germany.
Patricia A PeyserSchool of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Ozren PolasekFaculty of Medicine, University of Split, Split, Croatia.
Olli T RaitakariDepartment of Clinical Physiology and Nuclear Medicine, Turku University Hospital, Turku 20521, Finland; Research Centre of Applied and Preventive Cardiovascular Medicine, University of Turku, Turku 20520, Finland.
Frida RenströmGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden; Department of Biobank Research, Umeå University, Umeå, Västerbotten 901 87, Sweden.
Treva K RiceDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Paul M RidkerDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Antonietta RobinoMedical Genetics, IRCCS Burlo, Garofolo 34137, Italy.
Jennifer G RobinsonDepartment of Epidemiology and Medicine, University of Iowa, Iowa City, IA 52242, USA.
Lynda M RoseDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA.
Igor RudanUsher Institute of Population Health Sciences and Informatics, University of Edinburgh, Edinburgh EH8 9AG, UK.
Charumathi SabanayagamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore.
Babatunde L SalakoDepartment of Medicine, University of Ibadan, Ibadan, Nigeria.
Kevin SandowGenomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Carsten O SchmidtDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Institute for Community Medicine, University Medicine Greifswald, Greifswald 17475, Germany.
Pamela J SchreinerDivision of Epidemiology and Community Health, University of Minnesota School of Public Health, Minneapolis, MN 55454, USA.
William R ScottDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
Sudha SeshadriFramingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA; Department of Neurology, Boston University School of Medicine, Boston, MA 02118, USA.
Peter SeverInternational Centre for Circulatory Health, Imperial College London, London W2 1PG, UK.
Colleen M SitlaniCardiovascular Health Research Unit, Medicine, University of Washington, Seattle, WA 98101, USA.
Jennifer A SmithSchool of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Harold SniederDepartment of Epidemiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
John M StarrCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Alzheimer Scotland Dementia Research Centre, The University of Edinburgh, Edinburgh EH8 9JZ, UK.
Konstantin StrauchInstitute of Genetic Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Chair of Genetic Epidemiology, IBE, Faculty of Medicine, LMU Munich, Munich 81377, Germany.
Hua TangDepartment of Genetics, Stanford University, Stanford, CA 94305, USA.
Kent D TaylorGenomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Yik Ying TeoSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Genome Institute of Singapore, Agency for Science Technology and Research, Singapore 138672, Singapore; Life Sciences Institute, National University of Singapore, Singapore, Singapore 117456, Singapore; NUS Graduate School for Integrative Science and Engineering, National University of Singapore, Singapore 117456, Singapore; Department of Statistics and Applied Probability, National University of Singapore, Singapore 117546, Singapore.
Yih Chung ThamSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore.
André G UitterlindenDepartment of Internal Medicine, Erasmus University Medical Center, Rotterdam, the Netherlands.
Melanie WaldenbergerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; Institute of Epidemiology II, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany.
Lihua WangDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Ya X WangBeijing Institute of Ophthalmology, Beijing Ophthalmology and Visual Science Key Lab, Beijing Tongren Eye Center, Capital Medical University, Beijing, China 100730, China.
Wen Bin WeiBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China.
Christine WilliamsDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Gregory WilsonJackson Heart Study, Department of Public Health, Jackson State University, Jackson, MS 39213, USA.
Mary K WojczynskiDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Jie YaoGenomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Jian-Min YuanDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA; Division of Cancer Control and Population Sciences, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15232, USA.
Alan B ZondermanBehavioral Epidemiology Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Diane M BeckerGeneral Internal Medicine, GeneSTAR Research Program, Department of Medicine, Johns Hopkins University School of Medicine, Baltimore, MD 21287, USA.
Michael BoehnkeDepartment of Biostatistics and Center for Statistical Genetics, University of Michigan, Ann Arbor, MI 48109, USA.
Donald W BowdenDepartment of Biochemistry, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
John C ChambersDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; Department of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK.
Yii-Der Ida ChenGenomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Ulf de FaireInstitute of Environmental Medicine, Karolinska Institutet, Stockholm 17177, Sweden.
Ian J DearyCentre for Cognitive Ageing and Cognitive Epidemiology, The University of Edinburgh, Edinburgh EH8 9JZ, UK; Department of Psychology, The University of Edinburgh, Edinburgh EH8 9JZ, UK.
Tõnu EskoEstonian Genome Center, University of Tartu, Tartu 51010, Estonia; Broad Institute of the Massachusetts Institute of Technology and Harvard University, Boston, MA 02142, USA.
Martin FarrallDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
Terrence ForresterTropical Metabolism Research Unit, Tropical Medicine Research Institute, University of the West Indies, Mona JMAAW15, Jamaica.
Paul W FranksGenetic and Molecular Epidemiology Unit, Department of Clinical Sciences, Lund University, Malmö, Skåne 205 02, Sweden; Harvard T.H. Chan School of Public Health, Department of Nutrition, Harvard University, Boston, MA 02115, USA; Department of Public Health & Clinical Medicine, Umeå University, Umeå, Västerbotten 901 85, Sweden.
Barry I FreedmanDivision of Nephrology, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Philippe FroguelCNRS UMR 8199, European Genomic Institute for Diabetes (EGID), Institut Pasteur de Lille, University of Lille, Lille 59000, France; Department of Genomics of Common Disease, Imperial College London, London W12 0NN, UK.
Paolo GaspariniDepartment of Medical Sciences, University of Trieste, Trieste 34137, Italy; Division Experimental Genetics, Sidra, Doha 26999, Qatar.
Christian GiegerResearch Unit of Molecular Epidemiology, Helmholtz Zentrum München, German Research Center for Environmental Health, Neuherberg 85764, Germany; German Center for Diabetes Research (DZD e.V.), Neuherberg 85764, Germany.
Bernardo Lessa HortaPostgraduate Program in Epidemiology, Federal University of Pelotas, Pelotas, RS 96020220, Brazil.
Yi-Jen HungEndocrinology and Metabolism, Tri-Service General Hospital, National Defense Medical Center, Taipei City, Taipei 11490, Taiwan.
Jost B JonasBeijing Tongren Eye Center, Beijing Tongren Hospital, Capital Medical University, Beijing 100730, China; Department of Ophthalmology, Medical Faculty Mannheim, University Heidelberg, Mannheim 68167, Germany.
Norihiro KatoDepartment of Gene Diagnostics and Therapeutics, Research Institute, National Center for Global Health and Medicine, Tokyo 1628655, Japan.
Jaspal S KoonerDepartment of Cardiology, Ealing Hospital, Middlesex UB1 3HW, UK; National Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
Markku LaaksoInstitute of Clinical Medicine, Internal Medicine, University of Eastern Finland and Kuopio University Hospital, Kuopio 70210, Finland.
Terho LehtimäkiDepartment of Clinical Chemistry, Fimlab Laboratories, Tampere 33520, Finland; Department of Clinical Chemistry, Finnish Cardiovascular Research Center - Tampere, Faculty of Medicine and Lifes Sciences, University of Tampere, Tampere 33014, Finland.
Kae-Woei LiangSchool of Medicine, National Yang-ming University, Taipei, Taiwan; Cardiovascular Center, Taichung Veterans General Hospital, Taichung 40705, Taiwan; Department of Medicine, China Medical University, Taichung 40705, Taiwan.
Patrik K E MagnussonDepartment of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm 17177, Sweden.
Anne B NewmanDepartment of Epidemiology, Graduate School of Public Health, University of Pittsburgh, Pittsburgh, PA 15261, USA.
Albertine J OldehinkelDepartment of Psychiatry, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Alexandre C PereiraLab Genetics and Molecular Cardiology, Department of Cardiology, Heart Institute, University of Sao Paulo, Sao Paulo, Brazil; Genetics, Harvard Medical School, Boston, MA 02115, USA.
Susan RedlineSleep Medicine and Circadian Disorders, Brigham and Women's Hospital, Boston, MA 02115, USA.
Rainer RettigDZHK (German Center for Cardiovascular Research), partner site Greifswald, Greifswald 17475, Germany; Institute of Physiology, University Medicine Greifswald, Greifswald 17495, Germany.
Nilesh J SamaniDepartment of Cardiovascular Sciences, University of Leicester, Leicester LE3 9QP, UK; NIHR Leicester Cardiovascular Biomedical Research Unit, Glenfield Hospital, Leicester LE3 9QP, UK.
James ScottNational Heart and Lung Institute, Imperial College London, London W12 0NN, UK.
Xiao-Ou ShuDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Pim van der HarstDepartment of Cardiology, University of Groningen, University Medical Center Groningen, Groningen 9700 RB, the Netherlands.
Lynne E WagenknechtDepartment of Public Health Sciences, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Nicholas J WarehamMRC Epidemiology Unit, University of Cambridge, Cambridge CB2 0QQ, UK.
Hugh WatkinsDivision of Cardiovascular Medicine, Radcliffe Department of Medicine, University of Oxford, Oxford, Oxfordshire OX3 9DU, UK; Wellcome Centre for Human Genetics, University of Oxford, Oxford OX3 7BN, UK.
David R WeirInstitute for Social Research, Survey Research Center, University of Michigan, Ann Arbor, MI 48104, USA.
Ananda R WickremasingheDepartment of Public Health, University of Kelaniya, Ragama, Sri Lanka.
Tangchun WuDepartment of Occupational and Environmental Health and State Key Laboratory of Environmental Health for Incubating, School of Public Health, Tongji Medical College Huazhong University of Science and Technology, Wuhan, China.
Wei ZhengDivision of Epidemiology, Department of Medicine, Vanderbilt University School of Medicine, Nashville, TN 37203, USA.
Yoichiro KamataniLaboratory for Statistical Analysis, Center for Integrative Medical Sciences, RIKEN, Yokohama 230-0045, Japan.
Cathy C LaurieDepartment of Biostatistics, University of Washington, Seattle, WA 98105, USA.
Claude BouchardHuman Genomics Laboratory, Pennington Biomedical Research Center, Baton Rouge, LA 70808, USA.
Richard S CooperDepartment of Public Health Sciences, Loyola University Chicago, Maywood, IL 60153, USA.
Michele K EvansHealth Disparities Research Section, Laboratory of Epidemiology and Population Sciences, National Institute on Aging, NIH, Baltimore, MD 21224, USA.
Vilmundur GudnasonIcelandic Heart Association, Kopavogur 201, Iceland; Faculty of Medicine, University of Iceland, Reykjavik 101, Iceland.
Sharon L R KardiaSchool of Public Health, Department of Epidemiology, University of Michigan, Ann Arbor, MI 48109, USA.
Stephen B KritchevskySticht Center for Health Aging and Alzheimer's Prevention, Department of Internal Medicine, Wake Forest School of Medicine, Winston-Salem, NC 27157, USA.
Daniel LevyFramingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA; Population Sciences Branch, Division of Intramural Research, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20892, USA.
Jeff R O'ConnellDivision of Endocrinology, Diabetes, and Nutrition, University of Maryland School of Medicine, Baltimore, MD 21201, USA; Program for Personalized and Genomic Medicine, University of Maryland School of Medicine, Baltimore, MD 21201, USA.
Bruce M PsatyCardiovascular Health Research Unit, Epidemiology, Medicine and Health Services, University of Washington, Seattle, WA 98101, USA; Kaiser Permanente Washington, Health Research Institute, Seattle, WA 98101, USA.
Rob M van DamSaw Swee Hock School of Public Health, National University of Singapore, Singapore 117549, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Mario SimsJackson Heart Study, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39213, USA.
Donna K ArnettDean's Office, University of Kentucky College of Public Health, Lexington, KY 40536, USA.
Dennis O Mook-KanamoriDepartment of Clinical Epidemiology, Leiden University Medical Center, Leiden 2300RC, the Netherlands; Department of Public Health and Primary Care, Leiden University Medical Center, Leiden 2300RC, the Netherlands.
Tanika N KellyDepartment of Epidemiology, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA 70112, USA.
Ervin R FoxCardiology, Department of Medicine, University of Mississippi Medical Center, Jackson, MS 39216, USA.
Caroline HaywardMedical Research Council Human Genetics Unit, Institute of Genetics & Molecular Medicine, University of Edinburgh, Edinburgh EH4 2XU, UK.
Myriam FornageBrown Foundation Institute of Molecular Medicine, University of Texas Health Science Center at Houston, Houston, TX 77030, USA.
Charles N RotimiCenter for Research on Genomics and Global Health, National Human Genome Research Institute, NIH, Bethesda, MD 20892, USA.
Michael A ProvinceDivision of Statistical Genomics, Department of Genetics, Washington University School of Medicine, St. Louis, MO 63108, USA.
Cornelia M van DuijnDepartment of Epidemiology, Erasmus University Medical Center, Rotterdam, the Netherlands.
E Shyong TaiSaw Swee Hock School of Public Health, National University Health System and National University of Singapore, Singapore, Singapore 117549, Singapore; Duke-NUS Medical School, Singapore 169857, Singapore; Department of Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore 119228, Singapore.
Tien Yin WongSingapore Eye Research Institute, Singapore National Eye Centre, Singapore, Singapore 169856, Singapore; Ophthalmology & Visual Sciences Academic Clinical Program (Eye ACP), Duke-NUS Medical School, Singapore, Singapore 169857, Singapore; Department of Ophthalmology, Yong Loo Lin School of Medicine, National University of Singapore, Singapore, Singapore 117597, Singapore.
Ruth J F LoosIcahn School of Medicine at Mount Sinai, The Charles Bronfman Institute for Personalized Medicine, New York, NY 10029, USA; Icahn School of Medicine at Mount Sinai, The Mindich Child Health and Development Institute, New York, NY 10029, USA.
Alex P ReinerFred Hutchinson Cancer Research Center, University of Washington School of Public Health, Seattle, WA 98109, USA.
Jerome I RotterGenomic Outcomes, Department of Pediatrics, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA; Genomic Outcomes, Department of Medicine, LABioMed at Harbor-UCLA Medical Center, Torrance, CA 90502, USA.
Xiaofeng ZhuDepartment of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH 44106, USA.
Laura J BierutDepartment of Psychiatry, Washington University School of Medicine, St. Louis, MO 63110, USA.
W James GaudermanDivision of Biostatistics, Department of Preventive Medicine, University of Southern California, Los Angeles, CA 90032, USA.
Mark J CaulfieldWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Cardiovascular Biomedical Research Unit, Barts and The London School of Medicine and Dentistry, Queen Mary University of London, London EC1M 6BQ, UK.
Paul ElliottDepartment of Epidemiology and Biostatistics, Imperial College London, London W2 1PG, UK; MRC-PHE Centre for Environment and Health, Department of Epidemiology & Biostatistics, School of Public Health, Imperial College London, London, UK.
Kenneth RiceDepartment of Biostatistics, University of Washington, Seattle, WA 98105, USA.
Patricia B MunroeWilliam Harvey Research Institute, Clinical Pharmacology, Queen Mary University of London, London EC1M 6BQ, UK; NIHR Barts Cardiovascular Biomedical Research Unit, Queen Mary University of London, London EC1M 6BQ, UK.
Alanna C MorrisonDepartment of Epidemiology, Human Genetics, and Environmental Sciences, The University of Texas School of Public Health, Houston, TX 77030, USA.
L Adrienne CupplesDepartment of Biostatistics, Boston University School of Public Health, Boston, MA 02118, USA; Framingham Heart Study, National Heart, Lung, and Blood Institute, NIH, Bethesda, MD 20982, USA.
Dabeeru C RaoDivision of Biostatistics, Washington University School of Medicine, St. Louis, MO 63110, USA.
Daniel I ChasmanDivision of Preventive Medicine, Department of Medicine, Brigham and Women's Hospital, Boston, MA 02215, USA. Electronic address: dchasman@research.bwh.harvard.edu.
University of Washington · USImperial College London · GBUniversity of Michigan · USWake Forest University · USWashington University in St. Louis · USNational University of Singapore · SGBrigham and Women's Hospital · USErasmus MC · NLKarolinska Institutet · SEMRC Epidemiology Unit · GBNational Institute on Aging · USUniversity of Edinburgh · GBGerman Centre for Cardiovascular Research · DEIcahn School of Medicine at Mount Sinai · USUniversity of North Carolina at Chapel Hill · USBoston University · USHelmholtz Zentrum München · DERIKEN Center for Integrative Medical Sciences · JPThe Lundquist Institute · USUCLA Medical Center · US

Funding

HRS Yrs29-34: Y33 SSA CoFundingU01AG009740 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Jessica Faul, KENNETH M LANGA · 1990 to 2026
$555.8M
UCLA Clinical Translational Science InstituteUL1TR001881 · NCATS · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI ARLEEN F. BROWN, ARASH NAEIM · 2016 to 2026
$118.1M
Genetic epidemiology of complex diseasesZIAHG200362 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ROTIMI, CHARLES · 2009 to 2025
$54.7M
Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI PETER J TONTONOZ · 2003 to 2026
$40.4M
Tracking and Evaluation CoreU54GM115428 · NIGMS · UNIVERSITY OF MISSISSIPPI MED CTR · PI GRANGER, JOEY P. · 2016 to 2025
$38.2M
Genetic analysis of type II diabetes in Finnish populationZIAHG000024 · NHGRI · NATIONAL HUMAN GENOME RESEARCH INSTITUTE · PI ERDOS, MICHAEL · 2009 to 2025
$38.2M
Long Life Family Study: Data Management and Coordinating CenterU01AG023746 · NIA · WASHINGTON UNIVERSITY · PI PROVINCE, MICHAEL A. · 2004 to 2018
$29.2M
UC Davis Alzheimer's Disease Core CenterP30AG010129 · NIA · UNIVERSITY OF CALIFORNIA DAVIS · PI DECARLI, CHARLES · 1991 to 2020
$28.3M
Statistical Methods for Integrative Genomics in CancerP01CA196569 · NCI · UNIVERSITY OF SOUTHERN CALIFORNIA · PI KIMBERLY D SIEGMUND · 2016 to 2026
$25.5M
Regional Pilot And Feasibility Study Grants ProgramP30DK020572 · NIDDK · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Mehboob A Hussain · 2013 to 2026
$24.3M
Genome-Wide Association Analysis in Essential Hypertension (FEHGAS study)R01HL086694 · NHLBI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI ARAVINDA CHAKRAVARTI · 2007 to 2026
$21.2M
Research BaseP30DK072488 · NIDDK · UNIVERSITY OF MARYLAND BALTIMORE · PI MITCHELL, BRAXTON D, TAYLOR, SIMEON I. · 2005 to 2019
$17.3M
British Heart Foundation SP/13/2/30111Medical Research Council G0600237Medical Research Council G0601966Medical Research Council G0700931Medical Research Council G9521010Medical Research Council MC_UP_1605/7Medical Research Council MC_UU_00007/10Medical Research Council MC_UU_12015/1Medical Research Council MC_UU_12015/5Medical Research Council MR/K002414/1Medical Research Council MR/K006584/1Medical Research Council MR/K026992/1Medical Research Council MR/L01341X/1Medical Research Council MR/L01632X/1Medical Research Council MR/R023484/1NCATS NIH HHS UL1 TR001881NCI NIH HHS P01 CA196569NCI NIH HHS R01 CA144034NCI NIH HHS UM1 CA182876NHLBI NIH HHS K01 HL135405NHLBI NIH HHS K25 HL121091NHLBI NIH HHS R00 HL130580NHLBI NIH HHS R01 HL086694NHLBI NIH HHS R01 HL091069NHLBI NIH HHS R01 HL105756NHLBI NIH HHS R01 HL117078NHLBI NIH HHS R01 HL118305NHLBI NIH HHS R01 HL120393NHLBI NIH HHS R21 HL123677NHLBI NIH HHS T32 HL007055NHLBI NIH HHS U01 HL120393NHLBI NIH HHS U01 HL130114NIA NIH HHS P30 AG010129NIA NIH HHS R01 AG054076NIA NIH HHS U01 AG009740NIA NIH HHS U01 AG023746NIDDK NIH HHS P30 DK020572NIDDK NIH HHS P30 DK063491NIDDK NIH HHS P30 DK072488NIDDK NIH HHS R01 DK062370NIDDK NIH HHS U01 DK062370NIGMS NIH HHS U54 GM115428NIMHD NIH HHS R01 MD012765
6 · The paper itself

Abstract

Genome-wide association analysis advanced understanding of blood pressure (BP), a major risk factor for vascular conditions such as coronary heart disease and stroke. Accounting for smoking behavior may help identify BP loci and extend our knowledge of its genetic architecture. We performed genome-wide association meta-analyses of systolic and diastolic BP incorporating gene-smoking interactions in 610,091 individuals. Stage 1 analysis examined ∼18.8 million SNPs and small insertion/deletion variants in 129,913 individuals from four ancestries (European, African, Asian, and Hispanic) with follow-up analysis of promising variants in 480,178 additional individuals from five ancestries. We identified 15 loci that were genome-wide significant (p < 5 × 10

Indexed as

Genetic LociGenome-Wide Association StudyBlood PressureCohort StudiesDiastoleEpistasis, GeneticFemaleHumansMalePolymorphism, Single NucleotideQuantitative Trait LociRacial GroupsReproducibility of ResultsSmokingSystoleblood pressureGWASGxE interactionslifestylemulti-ancestrysmoking

Identifiers

PMID29455858
PMCPMC5985266
OpenAlexW2786593082

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