ArticlePsychological medicine2018
Distinct risk factors for obsessive and compulsive symptoms in chronic schizophrenia.
Article in Psychological medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.
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Who cites it
21 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Clozapine Optimization: A Delphi Consensus Guideline From the Treatment Response and Resistance in Psychosis Working Group.Schizophrenia bulletin · 2023Guideline
- Negative symptomatology and clozapine-induced obsessive-compulsive symptoms: a cross-sectional analysis.European archives of psychiatry and clinical neuroscience · 2026Article
- Smoking and obsessive-compulsive symptoms in patients with schizophrenia, schizoaffective disorder or bipolar disorder using electronic mental health records.BJPsych open · 2026Article
- Clozapine-induced obsessive-compulsive symptoms in schizophrenia: Clinical and cognitive determinants of dysfunctional checking.Psychological medicine · 2025Article
- Obsessive‒compulsive symptoms and associated factors among people with schizophrenia attending services at referral hospitals in Eastern Ethiopia.BMC psychiatry · 2025Article
- Prevalence of obsessive-compulsive symptoms in patients with schizophrenia treated with clozapine: a scoping review.BMC psychiatry · 2025Article
- The role of psychosis and clozapine load in excessive checking in treatment-resistant schizophrenia: longitudinal observational study.The British journal of psychiatry : the journal of mental science · 2024Observational
- Polygenetic risk scores and phenotypic constellations of obsessive-compulsive disorder in clozapine-treated schizophrenia.European archives of psychiatry and clinical neuroscience · 2024Article
- Cognitive inflexibility, obsessive-compulsive symptoms and traits and poor post-pandemic adjustment.Neuroscience applied · 2024Review
- The Neurobiological Underpinnings of Obsessive-Compulsive Symptoms in Psychosis, Translational Issues for Treatment-Resistant Schizophrenia.Biomolecules · 2023Review
- Obsessive-Compulsive, Psychotic, and Autism Dimensions Overlap in Real World: A Case Report.Clinical neuropharmacology · 2023Article
- Adjunct Triptorelin in the Treatment of Obsessive-Compulsive Disorder in Clients Receiving Selective Serotonin Reuptake Inhibitors (SSRIs).Iranian journal of psychiatry · 2021Article
- The Relationships Between Obsessive-Compulsive Disorder and Psychosis: An Unresolved Issue.Clinical neuropsychiatry · 2020Article
- Assessment of obsessive-compulsive disorder comorbidity and obsessive-compulsive symptom dimensions in patients with schizophrenia.Saudi medical journal · 2020Article
- Comparison of Clinical Characteristics Between the Patients with Schizophrenia on Clozapine Treatment with Those Taking Combination of Long-Acting Injectable and Oral Antipsychotics.Noro psikiyatri arsivi · 2019Article
- A cross sectional study of impact and clinical risk factors of antipsychotic-induced OCD.European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology · 2019Article
- Obsessions are strongly related to eating disorder symptoms in anorexia nervosa and atypical anorexia nervosa.Eating behaviors · 2019Article
- Obsessive-Compulsive Symptoms in Schizophrenia: an Up-To-Date Review of Literature.Current psychiatry reports · 2019Review
- Schizotypy and smooth pursuit eye movements as potential endophenotypes of obsessive-compulsive disorder.European archives of psychiatry and clinical neuroscience · 2019Article
- Clozapine-induced obsessive–compulsive symptoms: mechanisms and treatmentJournal of psychiatry & neuroscience : JPN · 2019Article
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
backgroundObsessive-compulsive disorder (OCD) is common in clozapine-treated patients although the actual prevalence, phenomenology and risk factors remain unclear. The aim of the present study was to address the three aforementioned questions.
methodsThe electronic records of a large cohort of clozapine-medicated schizophrenia patients routinely screened for OCD were used. The Obsessive Compulsive Inventory Revised version (OCI-R) was available from 118 cases and a 21 points cut-off threshold for OCD was defined.
resultsOCD prevalence was 47%, higher in patients on poly-pharmacy than on monotherapy (64% vs 31%; p = 0.001). Two OCI-R factors had significantly higher scores and distinct risk factors: checking behaviour (mean = 5.1; SD = 3.6) correlated with length of clozapine treatment (r = 0.21; p = 0.026), and obsessing factor (mean = 4.8; SD = 3.6) correlated with psychosis severity (r = 0.59; p = 0.001). These factors along with total OCI-R, did not correlate with either clozapine dose or plasma levels, after correcting for psychosis severity.
conclusionsScreening for OCD in clozapine patients, and probably in those treated with structurally similar drugs with potent antiserotoninergic properties, should be widely adopted by clinicians. Further research is needed to understand the pathophysiology underlying repetitive behavior onset in clozapine-treated patients.
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