Evidence map›Paper›PMID 29455416›Full record

ArticleCalcified tissue international2018

Pharmacological Inhibition of the Skeletal IKKβ Reduces Breast Cancer-Induced Osteolysis.

Silvia Marino, Ryan T Bishop, Patrick Mollat, Aymen I Idris

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Calcified tissue international, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.7field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 9 citations in OpenAlex.

  1. Differential Effects of a First-in-Class IKKCalcified tissue international · 2026
    Article
  2. Analysis of Signaling Pathways by Western Blotting and Immunoprecipitation.Methods in molecular biology (Clifton, N.J.) · 2025
    Article
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 2 countries.

Silvia MarinoDepartment of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
Ryan T BishopDepartment of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK.
Patrick MollatGalapagos SASU, 102 Avenue Gaston Roussel, 93230, Romainville, France.
Aymen I IdrisDepartment of Oncology and Metabolism, University of Sheffield, Medical School, Beech Hill Road, Sheffield, S10 2RX, UK. aymen.idris@sheffield.ac.uk.
University of Sheffield · GBEdinburgh Cancer Research · GBGalapagos (France) · FR

Funding

Cancer Research UKMedical Research Council MR/P020941/1
6 · The paper itself

Abstract

IKKβ has previously been implicated in breast cancer bone metastasis and bone remodelling. However, the contribution of IKKβ expressed by bone cells of the tumour microenvironment to breast cancer-induced osteolysis has yet to be investigated. Here, we studied the effects of the verified selective IKKβ inhibitors IKKβ

Indexed as

AnimalsApoptosisBone NeoplasmsBone RemodelingBreast NeoplasmsCaspasesCell DifferentiationCell Line, TumorCulture Media, ConditionedFemaleHumansI-kappa B KinaseMammary Neoplasms, AnimalMiceMice, Inbred BALB CMice, Inbred C57BLCaspasesCulture Media, ConditionedI-kappa B KinaseIKBKB protein, humanIkbkb protein, mouseBoneBreast cancerIKKβOsteoclastOsteoclastogenesisOsteolysis

Identifiers

PMID29455416
PMCPMC6061461
OpenAlexW2792571981

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.