Evidence map›Paper›PMID 29455378›Full record

ArticlePathology oncology research : POR2019

Age-Related Hearing Impairment Associated NAT2, GRM7, GRHL2 Susceptibility Gene Polymorphisms and Haplotypes in Roma and Hungarian Populations.

Petra Matyas, Etelka Postyeni, Katalin Komlosi, Renata Szalai, Judit Bene, Lili Magyari, Bela Melegh, Kinga Hadzsiev

Abstract read
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In one paragraph

Article in Pathology oncology research : POR, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.4field-weighted citation impact, top 45% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 7 citations in OpenAlex.

  1. Review
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  3. Grainyhead-like 2 as a double-edged sword in development and cancer.American journal of translational research · 2020
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Petra MatyasDepartment of Medical Genetics, University of Pecs, Medical School, Szigeti 12, Pecs, H-7624, Hungary.
Etelka PostyeniDepartment of Medical Genetics, University of Pecs, Medical School, Szigeti 12, Pecs, H-7624, Hungary.
Katalin KomlosiDepartment of Medical Genetics, University of Pecs, Medical School, Szigeti 12, Pecs, H-7624, Hungary.
Renata SzalaiDepartment of Medical Genetics, University of Pecs, Medical School, Szigeti 12, Pecs, H-7624, Hungary.
Judit BeneDepartment of Medical Genetics, University of Pecs, Medical School, Szigeti 12, Pecs, H-7624, Hungary.
Lili MagyariDepartment of Medical Genetics, University of Pecs, Medical School, Szigeti 12, Pecs, H-7624, Hungary.
Bela MeleghDepartment of Medical Genetics, University of Pecs, Medical School, Szigeti 12, Pecs, H-7624, Hungary. melegh.bela@pte.hu.
Kinga HadzsievDepartment of Medical Genetics, University of Pecs, Medical School, Szigeti 12, Pecs, H-7624, Hungary.
University of Pecs · HU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Age-related hearing impairment (ARHI) is the most frequent sensory disease in the elderly, which is caused by an interaction between genetic and environmental factors. Here we examined the ethnic differences, allele and genotype frequencies of the NAT2, GRM7, and GRHL2 genes pooled samples of healthy Hungarian and healthy and hearing impaired Roma people. Study populations of healthy Hungarian and Roma subjects were characterized for the rs1799930 NAT2, rs11928865 GRM7, rs10955255, rs13263539, and rs1981361 GRHL2 polymorphisms and deaf Roma subjects were characterized for the rs1799930 NAT2, rs13263539, and rs1981361 GRHL2 using a PCR-RFLP method. We found significant differences in minor allele frequencies for GRHL2 rs13263539 and rs1981361 polymorphism between healthy Roma and Hungarian samples (37.9% vs. 51.0% and 43.6% vs. 56.2%, respectively; p < 0.05). The differences of homozygous genotype of GRHL2 rs13263539 and rs1981361 variants, values were also significantly different (13.0% vs. 25.3% and 16.5 vs. 32.3%; p < 0.05). The NAT2 rs1799930 homozygous genotype was 14.0% in healthy Romas and 7.7% in Hungarians, while the minor A allele frequency was 38.0% and 26.7% in Roma and Hungarian population, respectively (p < 0.05). Furthermore, the frequency of GGT, GAC and GAT haplotypes was significantly higher in the Hungarian population than in healthy Roma (1.87 vs. 4.47%, 0.91 vs. 2.07% and 1.15 vs. 5.51%, respectively; p < 0.008). Present study revealed significant interethnic differences in allele polymorphisms of NAT2, GRM7 and GRHL2 exhibit quite marked ethnic differences in Roma populations that might have important implications for the preventive and therapeutic treatments in this population.

Indexed as

HaplotypesPolymorphism, Single NucleotideAdultArylamine N-AcetyltransferaseCase-Control StudiesDNA-Binding ProteinsFemaleFollow-Up StudiesGenotypeHumansHungaryMalePresbycusisPrognosisReceptors, Metabotropic GlutamateRomani PeopleArylamine N-AcetyltransferaseDNA-Binding ProteinsGRHL2 protein, humanmetabotropic glutamate receptor 7NAT2 protein, humanReceptors, Metabotropic GlutamateTranscription FactorsARHIGRHL2GRM7HungarianNAT2Roma

Identifiers

PMID29455378
OpenAlexW2788999054

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.