ArticleEuropean journal of pediatrics2018
Sepsis calculator implementation reduces empiric antibiotics for suspected early-onset sepsis.
Article in European journal of pediatrics, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05274776 (Safely Reduce Newborn Antibiotic Exposure With the Early-onset Sepsis Calculator), which is not on this map. Cited by 33 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Safely Reduce Newborn Antibiotic Exposure With the Early-onset Sepsis Calculator: a Cluster Randomized Study (EOS Calculator RCT)
Who cites it
33 citing papers in PubMed, 2 syntheses or guidelines pooled it.
- A systematic review of Perinatal Antibiotic Stewardship - where we are, where to go?Journal of perinatology : official journal of the California Perinatal Association · 2025Pooled it
- Pediatric Predictive Artificial Intelligence Implemented in Clinical Practice from 2010 to 2021: A Systematic Review.Applied clinical informatics · 2025Pooled it
- Reducing unnecessary antibiotic exposure among neonates evaluated for suspected early-onset sepsis through an adapted risk-stratification and antimicrobial stewardship pathway in northwest Ethiopia: a prospective quality improvement study.BMJ paediatrics open · 2026Article
- Comparing early-onset sepsis risk: risk calculator, American Academy of Pediatrics guidelines, and local care.Pediatric research · 2026Article
- Clinical Outcomes of the Adapted AAP 2019 Guidelines on Early Onset Sepsis in Thailand.Antibiotics (Basel, Switzerland) · 2025Article
- Four-factor nomogram for early-onset sepsis in preterm neonates: Development and internal validation of a stewardship tool.PloS one · 2025Article
- Assessing Diagnostic Performance of Molecular Culture for Neonatal Sepsis: Protocol of the CHAMPIONS Study.Diagnostics (Basel, Switzerland) · 2024Article
- Clinical and economic impacts of a modified-observational screening approach to well-appearing infants born to mothers with chorioamnionitis.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Evaluating a Modified Use of the Kaiser Permanente Early-onset Sepsis Risk Calculator to Reduce Antibiotic Exposure: a Retrospective Study.BMJ paediatrics open · 2024Article
- Article
- The impact of the early onset neonatal sepsis calculator on antibiotic initiation: a single center study in Israel.European journal of pediatrics · 2023Article
- Potential of Molecular Culture in Early Onset Neonatal Sepsis Diagnosis: A Proof of Principle Study.Microorganisms · 2023Article
- Article
- Computerized Clinical Decision Support Systems for the Early Detection of Sepsis Among Pediatric, Neonatal, and Maternal Inpatients: Scoping Review.JMIR medical informatics · 2022Article
- Assessing standards for prevention of early onset group B streptococcal (GBS) disease in Ireland.Irish journal of medical science · 2022Article
- Variations in Antibiotic Use and Sepsis Management in Neonatal Intensive Care Units: A European Survey.Antibiotics (Basel, Switzerland) · 2021Article
- C-reactive protein and the neonatal early-onset sepsis calculator for the diagnosis of neonatal sepsis.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2021Article
- Use of Early-Onset Sepsis Risk Calculator for Neonates ≥ 34 Weeks in a Large Tertiary Neonatal Centre, Saudi Arabia.Cureus · 2021Article
- Multicentre study found that adherence to national antibiotic recommendations for neonatal early-onset sepsis was low.Acta paediatrica (Oslo, Norway : 1992) · 2021Observational
- Umbilical Cord Procalcitonin to Detect Early-Onset Sepsis in Newborns: A Promising Biomarker.Frontiers in pediatrics · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Significant overtreatment with antibiotics for suspected early onset sepsis (EOS) constitutes a persisting clinical problem, generating unnecessary risks, harms, and costs for many newborns. We aimed to study feasibility and impact of a sepsis calculator to help guide antibiotic for suspected EOS in a European setting. In this single-center study, the sepsis calculator was implemented as an addition to and in accordance with existing protocols. One thousand eight hundred seventy-seven newborns ≥ 35 weeks of gestational age were prospectively evaluated; an analogous retrospective control group (n = 2076) was used for impact analysis. We found that empirical treatment with intravenous antibiotics for suspected EOS was reduced from 4.8 to 2.7% after sepsis calculator implementation (relative risk reduction 44% (95% confidence interval 21.4-59.5%)). No evidence for changes in time to treatment start, treatment duration, or proven sepsis rates was found. Adherence to sepsis calculator recommendation was 91%.
conclusionPragmatic and feasible implementation of the sepsis calculator yields a 44% reduction of empirical use of antibiotics for EOS, without signs of delay or prolongation of treatment. These findings warrant a multicenter, nation-wide, randomized study evaluating systematic use of the sepsis calculator prediction model and its effects in clinical practice outside of the USA. What is known: • Significant overtreatment with antibiotics for suspected early-onset sepsis results in unnecessary costs, risks, and harms. • Implementation of the sepsis calculator in the USA has resulted in a significant decrease in empirical antibiotic treatment, without apparent adverse events. What is new: • Implementation of the sepsis calculator in daily clinical decision-making in a Dutch teaching hospital is feasible in conjunction with existing protocols, with high adherence. • Antibiotic therapy for suspected early-onset sepsis was reduced by 44% following implementation of the calculator.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.