Trial reportLasers in medical science2018
Photobiomodulation (PBM) therapy at 904 nm mitigates effects of exercise-induced skeletal muscle fatigue in young women.
Trial report in Lasers in medical science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 3 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 3 syntheses or guidelines pooled it, 41 citations in OpenAlex.
- Effects of photobiomodulation therapy on the functional performance of healthy individuals: a systematic review with meta-analysis.Lasers in medical science · 2023Pooled it
- Deconstructing the Ergogenic Effects of Photobiomodulation: A Systematic Review and Meta-analysis of its Efficacy in Improving Mode-Specific Exercise Performance in Humans.Sports medicine (Auckland, N.Z.) · 2022Pooled it
- Effects of Various Physical Interventions on Reducing Neuromuscular Fatigue Assessed by Electromyography: A Systematic Review and Meta-Analysis.Frontiers in bioengineering and biotechnology · 2021Pooled it
- High-intensity versus low-intensity laser acupuncture in chronic, non-specific low back pain: a double-blinded, randomized controlled trial.Frontiers in medicine · 2026Trial
- Influence of photobiomodulation therapy on the physical performance of women during the follicular phase of the menstrual cycle: A double-blind Sham-controlled randomized clinical trial.Lasers in medical science · 2023Trial
- Photobiomodulation does not improve anaerobic performance in well-trained cyclists.Lasers in medical science · 2023Trial
- Trial
- Efficacy and Safety of Photobiomodulation in MELAS: Protocol for a Series of N-of-1 Trials.Journal of clinical medicine · 2025Article
- Photobiomodulation as Medicine: Low-Level Laser Therapy (LLLT) for Acute Tissue Injury or Sport Performance Recovery.Journal of functional morphology and kinesiology · 2024Review
- Photobiomodulation therapy as an adjunct to resistance exercises on muscle metrics, functional balance, functional capacity, and physical performance among older adults: A systematic scoping review.Lasers in medical science · 2024Article
- A Holistic Perspective on How Photobiomodulation May Influence Fatigue, Pain, and Depression in Inflammatory Bowel Disease: Beyond Molecular Mechanisms.Biomedicines · 2023Article
- Article
- Effects of Photobiomodulation on High-Intensity Intermittent Anaerobic Performance of Lower Limbs in Brazilian Jiu-Jitsu Athletes: A Randomized, Crossover, Double-Blind Clinical Trial.International journal of exercise science · 2023Article
- Effects of the association of different volumes of strength training with photobiomodulation therapy on insulin resistance: A protocol for a randomized, triple-blind, placebo-controlled trial.Contemporary clinical trials communications · 2022Article
- Full-Body Photobiomodulation Therapy Is Associated with Reduced Sleep Durations and Augmented Cardiorespiratory Indicators of Recovery.Sports (Basel, Switzerland) · 2022Article
- Photobiomodulation and Sports: Results of a Narrative Review.Life (Basel, Switzerland) · 2021Review
- Photobiomodulation Therapy at 808 nm Does Not Improve Biceps Brachii Performance to Exhaustion and Delayed-Onset Muscle Soreness in Young Adult Women: A Randomized, Controlled, Crossover Trial.Frontiers in physiology · 2021Article
- A Potential Role for Photobiomodulation Therapy in Disease Treatment and Prevention in the Era of COVID-19.Aging and disease · 2020Article
- Acquired Resilience: An Evolved System of Tissue Protection in Mammals.Dose-response : a publication of International Hormesis SocietyReview
- Clinical and scientific recommendations for the use of photobiomodulation therapy in exercise performance enhancement and post-exercise recovery: current evidence and future directions.Brazilian journal of physical therapyReview
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Muscle fatigue is a process influenced by several mechanisms such as concentration of metabolic substrates, changes in blood flow, and increases in reactive oxygen species that impair contractile muscle function. In this context, photobiomodulation has been investigated for preventing muscle fatigue, with reports of positive effects on muscle performance. This study aimed to investigate the effects of 904-nm LASER photobiomodulation on rectus femoris muscle performance in young women. Eighteen young women participated in a randomized, participant and assessor-blinded crossover trial with placebo control. Active LASER (904 nm, 60 mW, 250 Hz, 3.6 J per diode, total dose of 129.6 J) intervention was applied prior to an isokinetic fatigue protocol consisting of a set of 60 concentric quadricep contractions at a constant dynamometer angular velocity of 180°/s. Compared to placebo, LASER photobiomodulation significantly reduced muscle fatigue across a range of indicators including reduced ratings of perceived exertion (P = 0.0139), and increased electromyographic fatigue index (EFI) (P = 0.005). The isokinetic dynamometer performance analysis demonstrated that LASER photobiomodulation increased peak torque (P = 0.04), time to peak torque (P = 0.042), total work (P = 0.032), average power (P = 0.0007), and average peak torque (P = 0.019) between both experimental conditions. No significant difference was observed for work fatigue index (P = 0.29) or for lactate concentration (P > 0.05). Photobiomodulation at 904 nm was effective in reducing fatigue levels and increasing muscle performance in young active women but had no effect on lactate levels.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.