Evidence map›Paper›PMID 29455172›Full record

Observational studyBMJ open2018

Transmission of ESBL-producing Enterobacteriaceae and their mobile genetic elements-identification of sources by whole genome sequencing: study protocol for an observational study in Switzerland.

Tanja Stadler, Dominik Meinel, Lisandra Aguilar-Bultet, Jana S Huisman, Ruth Schindler, Adrian Egli, Helena M B Seth-Smith, Lucas Eichenberger, Peter Brodmann, Philipp Hübner and 2 more

Open access · goldAbstract readObservational Study
In one paragraph

Observational study in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed
1.4field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 40 citations in OpenAlex.

  1. Article
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  5. Article
  6. Review
  7. Phylogenetic Characterization of ResistantBioinformatics and biology insights · 2024
    Article
  8. Article
  9. Antimicrobial agents and chemotherapy · 2023
    Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. The effect of sequencing and assembly on the inference of horizontal gene transfer on chromosomal and plasmid phylogenies.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2022
    Article
  15. Article
  16. Identification of a Cluster of Extended-spectrum Beta-Lactamase-Producing Klebsiella pneumoniae Sequence Type 101 Isolated From Food and Humans.Clinical infectious diseases : an official publication of the Infectious Diseases Society of America · 2021
    Article
  17. Environmental Spread of Antibiotic Resistance.Antibiotics (Basel, Switzerland) · 2021
    Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 1 country.

Tanja StadlerDepartment of Biosystems Science and Engineering, Eidgenössische Technische Hochschule (ETH) Zürich, Basel, Switzerland.
Dominik MeinelDivision of Clinical Microbiology, University Hospital Basel, Basel, Switzerland.
Lisandra Aguilar-BultetDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University Basel, Basel, Switzerland.
Jana S HuismanSwiss Institute of Bioinformatics, Lausanne, Switzerland.
Ruth SchindlerDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University Basel, Basel, Switzerland.
Adrian EgliDivision of Clinical Microbiology, University Hospital Basel, Basel, Switzerland.
Helena M B Seth-SmithDivision of Clinical Microbiology, University Hospital Basel, Basel, Switzerland.
Lucas EichenbergerBiosafety Laboratory, State Laboratory Basel-City, Basel, Switzerland.
Peter BrodmannBiosafety Laboratory, State Laboratory Basel-City, Basel, Switzerland.
Philipp HübnerBiosafety Laboratory, State Laboratory Basel-City, Basel, Switzerland.
Claudia BaguttiBiosafety Laboratory, State Laboratory Basel-City, Basel, Switzerland.
Sarah Tschudin-SutterDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, University Basel, Basel, Switzerland.
University Hospital of Basel · CHETH Zurich · CHUniversity of Basel · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionExtended-spectrum beta-lactamases (ESBL)-producing Enterobacteriaceae were first described in relation with hospital-acquired infections. In the 2000s, the epidemiology of ESBL-producing organisms changed as especially ESBL-producing METHODS AND ANALYSIS: This protocol presents an observational study that will be performed at the University Hospital Basel and in the city of Basel, Switzerland. ESBL-producing Enterobacteriaceae will be collected from any specimens obtained by routine clinical practice or by active screening in both inpatient and outpatient settings, as well as from wastewater samples and foodstuffs, both collected monthly over a 12-month period for analyses by whole genome sequencing. Bacterial chromosomal, plasmid and ESBL-gene sequences will be compared within the cohort to determine genetic relatedness and migration between humans and their environment. ETHICS AND DISSEMINATION: This study has been approved by the local ethics committee (Ethikkommission Nordwest-und Zentralschweiz) as a quality control project (Project-ID 2017-00100). The results of this study will be published in peer-reviewed medical journals, communicated to participants, the general public and all relevant stakeholders.

Indexed as

Interspersed Repetitive Sequencesbeta-LactamasesCommunity-Acquired InfectionsCross InfectionEnterobacteriaceaeEnterobacteriaceae InfectionsHumansProspective StudiesResearch DesignRetrospective StudiesSwitzerlandTertiary Care CentersWhole Genome Sequencingbeta-LactamasesenterobacteriaceaeepidemiologyEsblextended-spectrum beta-lactamasesone-healthplasmids

Identifiers

PMID29455172
PMCPMC5855333
OpenAlexW2792968938

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.