ArticleBMJ open2018
Pulmonary metastasis in rectal cancer: a retrospective study of clinicopathological characteristics of 404 patients in Chinese cohort.
Article in BMJ open, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 21 citations in OpenAlex.
- The Differential Diagnostic Value of Radiomics Signatures Between Single-Nodule Pulmonary Metastases and Second Primary Lung Cancer in Patients with Colorectal Cancer.Technology in cancer research & treatmentTrial
- Adverse Pathological Features and Worse Prognosis in Rectal Cancer Compared With Colon Cancer in T1 and T2 Stages.DEN open · 2027Article
- Development and internal validation of a prognostic nomogram for lung metastasis in locally advanced rectal cancer incorporating molecular markers.Translational cancer research · 2026Article
- Prognostic nomogram for overall survival in rectal cancer with synchronous lung metastases using Surveillance, Epidemiology, and End Results data and a single-center external validation cohort.Journal of gastrointestinal oncology · 2025Article
- Article
- Radiomic score for lung nodules as a prognostic biomarker in locally advanced rectal cancer patients: A bi-institutional study.Cancer medicine · 2024Article
- Onward Spread from Liver Metastases Is a Major Cause of Multi-Organ Metastasis in a Mouse Model of Metastatic Colon Cancer.Cancers · 2024Article
- Clinical study on risk factors related to postoperative recurrence or metastasis of rectal cancer: a retrospective cohort study.Journal of gastrointestinal oncology · 2022Article
- National variation in pulmonary metastasectomy for colorectal cancer.Colorectal disease : the official journal of the Association of Coloproctology of Great Britain and Ireland · 2021Article
- MRI of rectal cancer-relevant anatomy and staging key points.Insights into imaging · 2020Review
- Systematic review: Incidence, risk factors, survival and treatment of bone metastases from colorectal cancer.Journal of bone oncology · 2018Review
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesThis study aim to investigate the incidence, timing and risk factors of metachronous pulmonary recurrence after curative resection in patients with rectal cancer.
designA retrospective cohort study.
settingThis study was conducted at a tertiary referral cancer hospital.
participantsA total of 404 patients with rectal cancer who underwent curative resection from 2007 to 2012 at Beijing Hospital were enrolled in this study.
interventionsThe pattern of recurrence was observed and evaluated. PRIMARY AND SECONDARY OUTCOME MEASURES: The incidence and timing of recurrences by site were calculated, and the risk factors of pulmonary recurrence were analysed.
resultsThe 5-year disease-free survival for the entire cohort was 77.0%. The most common site of recurrence was the lungs, with an incidence of 11.4%, followed by liver. Median interval from rectal surgery to diagnosis of pulmonary recurrence was much longer than that of hepatic recurrence (20 months vs 10 months, P=0.022). Tumour location, pathological tumor-node-metastasis (TNM) stage and positive circumferential resection margin were identified as independent risk factors for pulmonary recurrence. A predictive model based on the number of risk factors identified on multivariate analysis was developed, 5-year pulmonary recurrence-free survival for patients with 0, 1, 2 and 3 risk factors was 100%, 90.4%, 77.3% and 70.0%, respectively (P<0.001).
conclusionsThis study emphasised that the lung was the most common site of metachronous metastasis in patients with rectal cancer who underwent curative surgery. For patients with unfavourable risk profiles, a more intensive surveillance programme that could lead to the early detection of recurrence is strongly needed.
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