Evidence map›Paper›PMID 29455085›Full record

ArticleTranslational oncology2018

Correlation of ADC With Pathological Treatment Response for Radiation Therapy of Pancreatic Cancer.

Entesar Dalah, Beth Erickson, Kiyoko Oshima, Diane Schott, William A Hall, Eric Paulson, An Tai, Paul Knechtges, X Allen Li

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Translational oncology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. MRI for restaging pancreatic cancer.Insights into imaging · 2026
    Article
  3. Review
  4. Article
  5. Diffusion-weighted Echo Planar Imaging with Compressed SENSE (EPICS-DWI) for Pancreas Assessment: A Multicenter Study.Magnetic resonance in medical sciences : MRMS : an official journal of Japan Society of Magnetic Resonance in Medicine · 2025
    Article
  6. Toward diffusion MRI in the diagnosis and treatment of pancreatic cancer.Medical oncology (Northwood, London, England) · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Entesar DalahDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Medical Diagnostic Imaging, College of Health Science, University of Sharjah, UAE. Electronic address: edalah@sharjah.ac.ae.
Beth EricksonDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: BErickson@mcw.edu.
Kiyoko OshimaDepartment of Pathology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: koshima@mcw.edu.
Diane SchottDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: dschott@mcw.edu.
William A HallDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: whall@mcw.edu.
Eric PaulsonDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA; Department of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: epaulson@mcw.edu.
An TaiDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: atai@mcw.edu.
Paul KnechtgesDepartment of Radiology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: pknechtges@mcw.edu.
X Allen LiDepartment of Radiation Oncology, Medical College of Wisconsin, Milwaukee, WI, USA. Electronic address: ali@mcw.edu.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate the feasibility of using apparent diffusion coefficient (ADC) to assesspathological treatment response in pancreatic ductal adenocarcinoma (PDAC) following neoadjuvant chemoradiation (nCR). MATERIALS/

methodsMRI and pathological data collected for 25patients with resectable and borderline resectable PDAC following nCR were retrospectively analyzed. Pre- and post-nCR mean ADC values in the tumors were compared using Wilcoxon matched pairs test. Correlation of pathological treatment response and ADC values was assessed using Pearson's correlation coefficient test and receiver-operating-curve (ROC) analysis.

resultsThe average mean and standard deviation (SD) of the ADC values for all the patients analyzed were significantly higher in post-nCR (1.667±0.161×10

conclusionChanges of pre- and post-treatment ADC values significantly correlated with pathological treatment response for PDAC patients treated with chemoradiation therapy, indicating that the ADC could be used to assesstreatment response for PDAC.

Identifiers

PMID29455085
PMCPMC5852406

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.