ReviewCurrent opinion in neurobiology2018
Mixed selectivity encoding and action selection in the prefrontal cortex during threat assessment.
Review in Current opinion in neurobiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed.
- Dopaminergic projections to the prefrontal cortex are critical for rapid threat avoidance learning.Current biology : CB · 2025Article
- Infralimbic Projections to the Substantia Innominata-Ventral Pallidum Constrain Defensive Behavior during Extinction Learning.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Microglial repopulation reverses radiation-induced cognitive dysfunction by restoring medial prefrontal cortex activity and modulating leukotriene-C4 synthesis.Acta neuropathologica communications · 2025Article
- Transformations in prefrontal ensemble activity underlying rapid threat avoidance learning.Current biology : CB · 2025Article
- Assessing data imbalance correction methods and gaze entropy for collision prediction.PloS one · 2025Article
- Review
- Visual perceptual learning of feature conjunctions leverages non-linear mixed selectivity.NPJ science of learning · 2024Article
- Using fMRI to examine nonlinear mixed selectivity tuning to task and category in the human brain.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- Anatomically distributed neural representations of instincts in the hypothalamus.bioRxiv : the preprint server for biology · 2023Article
- Distinct circuits in anterior cingulate cortex encode safety assessment and mediate flexibility of fear reactions.Neuron · 2023Article
- Abstraction of Reward Context Facilitates Relative Reward Coding in Neural Populations of the Macaque Anterior Cingulate Cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Dynamic influences on the neural encoding of social valence.Nature reviews. Neuroscience · 2022Review
- Natural behavior is the language of the brain.Current biology : CB · 2022Review
- A specialized spinal circuit for command amplification and directionality during escape behavior.Proceedings of the National Academy of Sciences of the United States of America · 2021Article
- Article
- Absence Makes the Mind Grow Fonder: Reconceptualizing Studies of Safety Learning in Translational Research on Anxiety.Cognitive, affective & behavioral neuroscience · 2021Review
- Integration of value and action in medial prefrontal neural systems.International review of neurobiology · 2021Review
- Distinct prefrontal top-down circuits differentially modulate sensorimotor behavior.Nature communications · 2020Article
- Viewpoints: Approaches to defining and investigating fear.Nature neuroscience · 2019Article
- Avoid-approach conflict behaviors differentially affected by anxiolytics: implications for a computational model of risky decision-making.Psychopharmacology · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors.
Funding
Abstract
The medial prefrontal cortex (mPFC) regulates expression of emotional behavior. The mPFC combines multivariate information from its inputs, and depending on the imminence of threat, activates downstream networks that either increase or decrease the expression of anxiety-related motor behavior and autonomic activation. Here, we selectively highlight how subcortical input to the mPFC from two example structures, the amygdala and ventral hippocampus, help shape mixed selectivity encoding and action selection during emotional processing. We outline a model where prefrontal subregions modulate behavior along orthogonal motor dimensions, and exhibit connectivity that selects for expression of one behavioral strategy while inhibiting the other.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.