Evidence map›Paper›PMID 29454648›Full record

ArticleCellular immunology2018

FOXP3 renders activated human regulatory T cells resistant to restimulation-induced cell death by suppressing SAP expression.

Gil Katz, Kelsey Voss, Toria F Yan, Yong Chan Kim, Robert L Kortum, David W Scott, Andrew L Snow

Abstract read
In one paragraph

Article in Cellular immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Article
  6. Immune Checkpoint Receptors Signaling in T Cells.International journal of molecular sciences · 2022
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Gil KatzDepartment of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Kelsey VossDepartment of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Toria F YanDepartment of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Yong Chan KimDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Robert L KortumDepartment of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
David W ScottDepartment of Medicine, Uniformed Services University of the Health Sciences, Bethesda, MD, United States.
Andrew L SnowDepartment of Pharmacology & Molecular Therapeutics, Uniformed Services University of the Health Sciences, Bethesda, MD, United States. Electronic address: andrew.snow@usuhs.edu.
Uniformed Services University of the Health Sciences · US

Funding

SAP/NTB-A Signaling in T Cell Restimulation-Induced Cell DeathR01GM105821 · NIGMS · HENRY M. JACKSON FDN FOR THE ADV MIL/MED · PI SNOW, ANDREW L · 2015 to 2019
$1.6M
NIGMS NIH HHS R01 GM105821
6 · The paper itself

Abstract

Restimulation-induced cell death (RICD) is an apoptotic program that regulates effector T cell expansion, triggered by repeated stimulation through the T cell receptor (TCR) in the presence of interleukin-2 (IL-2). Although CD4

Indexed as

AdultApoptosisCell DeathForkhead Transcription FactorsHealthy VolunteersHumansLymphocyte ActivationPromoter Regions, GeneticReceptors, Antigen, T-CellSignaling Lymphocytic Activation Molecule Associated ProteinSignal TransductionT-Lymphocytes, RegulatoryForkhead Transcription FactorsFOXP3 protein, humanReceptors, Antigen, T-CellSH2D1A protein, humanSignaling Lymphocytic Activation Molecule Associated ProteinApoptosisFOXP3Regulatory T cellsRestimulation-induced cell deathSAP

Identifiers

PMID29454648
PMCPMC5889721
OpenAlexW2790011611

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.