ArticleVirology journal2018
High risk human papillomavirus prevalence and genotype distribution among women infected with HIV in Manaus, Amazonas.
Article in Virology journal, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 2 of them syntheses that pooled it.
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Who cites it
32 citing papers in PubMed, 2 syntheses or guidelines pooled it, 54 citations in OpenAlex.
- The Impact of Antiretroviral Therapy (ART) on HPV Persistence and Cervical Cancer Progression Among Women with HPV/HIV Co-infection: A Systematic Review.AIDS and behavior · 2025Pooled it
- The Burden of HPV Infections and HPV-Related Diseases Among People With HIV: A Systematic Literature Review.Journal of medical virology · 2025Pooled it
- High Burden of High-Risk Human Papillomavirus Infections Among Women Living With HIV in Meru, Kenya.Cureus · 2026Article
- Article
- Epidemiology and genotype distribution of human papillomavirus (HPV) in Northern Iran.BMC infectious diseases · 2026Article
- Prevalence of High-Risk Human Papillomavirus Infection and Associated Risk Factors Among Women Attending the Gynecology Unit in Bahir Dar, Northwest Ethiopia.Clinical Medicine Insights. Oncology · 2026Article
- Article
- Multi-Target Molecular Detection of Sexually Transmitted Infections in Women Living with HIV in Northeastern Brazil.Tropical medicine and infectious disease · 2025Article
- Prevalence and risk factors of high-risk cervical HPV infections among women attending Debre Tabor hospital family planning and gynecology clinic, Northcentral Ethiopia.Scientific reports · 2025Article
- Prevalence and distribution of human papillomavirus genotypes in women living with HIV: a cross-sectional study in Iran.BMC infectious diseases · 2025Article
- Molecular epidemiology of high-risk human papillomavirus infection and its predictive factors among women living with HIV in Northeast Ethiopia: a facility-based cross-sectional study.BMC infectious diseases · 2025Article
- Prevalence and Associated Factors for HPV in People Living with HIV: Are INSTIs Protective Against HPV-16? The GAIA Study.Viruses · 2025Article
- Prevalence and factors associated with high-risk human papillomavirus infection in women living with HIV/AIDS at a referral center: a cross-sectional study, Vitória, 2021-2022.Epidemiologia e servicos de saude : revista do Sistema Unico de Saude do Brasil · 2025Article
- Prevalence and genotype distribution of cervical HPV among women living with and without HIV in selected health facilities in Limpopo province, South Africa.Southern African journal of infectious diseases · 2025Article
- Decoding impact of human papillomavirus in gynecological oncology: a narrative review.Obstetrics & gynecology science · 2025Article
- Factors associated with human papillomavirus infections among women living with HIV in public health facilities in Western Oromia, Ethiopia.BMC women's health · 2024Article
- Human papillomavirus in women infected with human immunodeficiency virus: association with viral load and lymphocyte count.Revista do Instituto de Medicina Tropical de Sao Paulo · 2024Article
- Peripheral blood lymphocytes influence human papillomavirus infection and clearance: a retrospective cohort study.Virology journal · 2023Article
- Prevalence of high-risk human papillomavirus infections and associated factors among women living with HIV in Shashemene town public health facilities, Southern Ethiopia.BMC women's health · 2023Article
- High prevalence of HPV 18 and multiple infections with oncogenic HPV genotypes in women at risk of cervical cancer examined in Manaus, Brazil.Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologica · 2023Article
Corrections and comments
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Authors and funding
6 authors at 4 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundHuman immunodeficiency virus (HIV)-positive women have a high prevalence of human papillomavirus (HPV), and are infected with a broader range of HPV types than HIV-negative women. We aimed to determine the prevalence of cervical cytologic abnormalities, high-risk (HR)-HPV prevalence, type distribution according to the severity of cervical lesions and CD4 cell count and identify factors associated with HR-HPV infection among women living with HIV in Manaus, Amazonas.
methodsWe enrolled 325 women living with HIV that attended an infectious diseases referral hospital. Each woman underwent a gynecological exam, cervical cytology, HR-HPV detection by Polymerase chain Reaction (PCR) using the BD Onclarity™ HPV Assay, colposcopy and biopsy, when necessary. We assessed the associations between potential risk factors and HR-HPV infection.
resultsOverall, 299 (92.0%) women had a PCR result. The prevalence of HR-HPV- infection was 31.1%. The most prevalent HR-HPV types were: 56/59/66 (32.2%), 35/39/68 (28.0%), 52 (21.5%), 16 (19.4%), and 45 (12.9%). Among the women with HR-HPV infection (n = 93), 43.0% had multiple infections. Women with HPV infection showed higher prevalence of cervical abnormalities than that HPV-negative (LSIL: 22.6% vs. 1.5%; HSIL: 10.8% vs. 0.0%). The prevalence of HR-HPV among women with cytological abnormalities was 87.5% for LSIL and 100.0% for HSIL. Women with CD4 < 200 cell/mm
conclusionsHR-HPV and abnormal cytology prevalence are high among women in the Amazonas. The low CD4 cell count was an important determinant of HPV infection and abnormal cytological findings. HPV quadrivalent vaccination used in Brazil might not offer protection for an important fraction of HPV-related disease burden in women living with HIV. This is partly explained by the high presence of non targeted vaccine HR-HPVs, such as the HPV genotype groups 56/59/66, 35/39/68 and individually HPV-52 and HPV-45, some of which contribute to high-grade lesion.
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