ArticleVascular pharmacology2018
Renal perivascular adipose tissue: Form and function.
Article in Vascular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
21 citing papers in PubMed, 30 citations in OpenAlex.
- Presence and Variability of the Microbiome in Perivascular Adipose Tissue: A Whole-Genome Sequencing Study in Dahl SS Rats.Life (Basel, Switzerland) · 2026Article
- Depot-specific metabolic and inflammatory profiles in perirenal and renal sinus adipose tissue.Molecular medicine (Cambridge, Mass.) · 2025Article
- CARDIAL-MS (CArdio-Renal-DIAbetes-Liver-Metabolic Syndrome): a new proposition for an integrated multisystem metabolic disease.Diabetology & metabolic syndrome · 2025Review
- Body composition as a potential imaging biomarker for predicting the progression risk of chronic kidney disease.Insights into imaging · 2024Article
- Perivascular Adipose Tissue and Uterine Artery Adaptations to Pregnancy.Microcirculation (New York, N.Y. : 1994) · 2024Review
- Obesity, Cardiovascular and Neurodegenerative Diseases: Potential Common Mechanisms.Physiological research · 2023Review
- Prognostic impact of renal sinus fat accumulation in patients with chronic kidney disease.Clinical and experimental nephrology · 2023Article
- Article
- High doses of tyramine stimulate glucose transport in human fat cells.Journal of physiology and biochemistry · 2022Article
- With a Little Help From My Friends: the Role of the Renal Collateral Circulation in Atherosclerotic Renovascular Disease.Hypertension (Dallas, Tex. : 1979) · 2022Review
- Prenatal Exposure to Methamphetamine Causes Vascular Dysfunction in Adult Male Rat Offspring.Frontiers in cardiovascular medicine · 2022Article
- Benefits of Curcumin in the Vasculature: A Therapeutic Candidate for Vascular Remodeling in Arterial Hypertension and Pulmonary Arterial Hypertension?Frontiers in physiology · 2022Review
- T cells mediate cell non-autonomous arterial ageing in mice.The Journal of physiology · 2021Article
- Combined renal and common hepatic artery denervation as a novel approach to reduce cardiometabolic risk: technical approach, feasibility and safety in a pre-clinical model.Clinical research in cardiology : official journal of the German Cardiac Society · 2021Article
- Roles of Perivascular Adipose Tissue in Hypertension and Atherosclerosis.Antioxidants & redox signaling · 2021Review
- Vascular reactivity stimulated by TMA and TMAO: Are perivascular adipose tissue and endothelium involved?Pharmacological research · 2021Article
- Perivascular Adipose Tissue Regulates Vascular Function by Targeting Vascular Smooth Muscle Cells.Arteriosclerosis, thrombosis, and vascular biology · 2020Review
- Renal sinus fat and renal hemodynamics: a cross-sectional analysis.Magma (New York, N.Y.) · 2020Article
- Perivascular adipose tissue in cardiovascular diseases-an update.Anatolian journal of cardiology · 2019Review
- Relevance of Targeting the Distal Renal Artery and Branches with Radiofrequency Renal Denervation Approaches-A Secondary Analysis from a Hypertensive CKD Patient Cohort.Journal of clinical medicine · 2019Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Renal sympathetic activity affects blood pressure in part by increasing renovascular resistance via release of norepinephrine (NE) from sympathetic nerves onto renal arteries. Here we test the idea that adipose tissue adjacent to renal blood vessels, i.e. renal perivascular adipose tissue (RPVAT), contains a pool of NE which can be released to alter renal vascular function. RPVAT was obtained from around the main renal artery/vein of the male Sprague Dawley rats. Thoracic aortic PVAT and mesenteric PVAT also were studied as brown-like and white fat comparators respectively. RPVAT was identified as a mix of white and brown adipocytes, because of expression of both brown-like (e.g. uncoupling protein 1) and white adipogenic genes. All PVATs contained NE (ng/g tissue, RPVAT:524 ± 68, TAPVAT:740 ± 16, MPVAT:96 ± 24). NE was visualized specifically in RPVAT adipocytes by immunohistochemistry. The presence of RPVAT (+RPVAT) did not alter the response of isolated renal arteries to NE compared to responses of arteries without RPVAT (-RPVAT). By contrast, the maximum contraction to the sympathomimetic tyramine was ~2× greater in the renal artery +PVAT versus -PVAT. Tyramine-induced contraction in +RPVAT renal arteries was reduced by the α
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.