Evidence map›Paper›PMID 29453900›Full record

ArticleCancer science2018

Downregulation of reticulocalbin-1 differentially facilitates apoptosis and necroptosis in human prostate cancer cells.

Xiaofei Liu, Nianzhao Zhang, Dawei Wang, Deyu Zhu, Quan Yuan, Xiulei Zhang, Lilin Qian, Huanmin Niu, Yi Lu, Guijie Ren and 2 more

Open access · goldAbstract read
In one paragraph

Article in Cancer science, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed, 1 pooled it
1.6field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 1 synthesis or guideline pooled it, 52 citations in OpenAlex.

  1. Metabolic cell death in cancer: mechanisms and therapeutic potential.Apoptosis : an international journal on programmed cell death · 2025
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 2 institutions in 1 country.

Xiaofei LiuDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.ORCID http://orcid.org/0000-0001-8786-8758
Nianzhao ZhangDepartment of Urology, Qilu Hospital, Shandong University, Jinan, China.
Dawei WangDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Deyu ZhuDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Quan YuanDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Xiulei ZhangDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Lilin QianDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Huanmin NiuDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Yi LuDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Guijie RenDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Keli TianDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Huiqing YuanDepartment of Biochemistry and Molecular Biology, Shandong University School of Medicine, Jinan, China.
Shandong University · CNQilu Hospital of Shandong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Reticulocalbin 1 (RCN1), an endoplasmic reticulum (ER)-resident Ca

Indexed as

AnimalsApoptosisCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 2CaspasesCell Cycle CheckpointsCell Line, TumorCell ProliferationCell SurvivalDown-RegulationeIF-2 KinaseEndoplasmic Reticulum Chaperone BiPEndoplasmic Reticulum StressG2 Phase Cell Cycle CheckpointsHeat-Shock ProteinsHumansCalcium-Binding ProteinsCalcium-Calmodulin-Dependent Protein Kinase Type 2CaspaseseIF-2 KinaseEndoplasmic Reticulum Chaperone BiPHeat-Shock ProteinsHSPA5 protein, humanHspa5 protein, mouseRCN1 protein, humanapoptosisendoplasmic reticulumnecroptosisprostate cancerreticulocalbin 1

Identifiers

PMID29453900
PMCPMC5891187
OpenAlexW2793544961

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.