Evidence map›Paper›PMID 29453777›Full record

ArticleEpilepsia2018

Intramuscular allopregnanolone and ganaxolone in a mouse model of treatment-resistant status epilepticus.

Dorota Zolkowska, Chun-Yi Wu, Michael A Rogawski

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Epilepsia, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed, 3 pooled it
3.6field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

37 citing papers in PubMed, 3 syntheses or guidelines pooled it, 58 citations in OpenAlex.

  1. Pooled it
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  3. Neurosteroids and Seizure Activity.Frontiers in endocrinology · 2020
    Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 2 institutions in 1 country.

Dorota ZolkowskaDepartment of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Chun-Yi WuDepartment of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA.
Michael A RogawskiDepartment of Neurology, School of Medicine, University of California, Davis, Sacramento, CA, USA.ORCID 0000-0002-3296-8193
University of California, Davis · USUniversity of California Davis Medical Center · US

Funding

Training and Education CoreU54NS079202 · NINDS · UNIVERSITY OF CALIFORNIA AT DAVIS · PI LEIN, PAMELA J · 2012 to 2021
$35.7M
NINDS NIH HHS NS079202NINDS NIH HHS U54 NS079202
6 · The paper itself

Abstract

Allopregnanolone (5α-pregnan-3α-ol-20-one) and its synthetic 3β-methyl analog, ganaxolone, are positive allosteric modulators of synaptic and extrasynaptic γ-aminobutyric acid (GABA)

Indexed as

AnimalsAnticonvulsantsBrainBridged-Ring CompoundsConvulsantsDisease Models, AnimalDose-Response Relationship, DrugInjections, IntramuscularLongitudinal StudiesMaleMicePregnanoloneStatus EpilepticusTime FactorsAnticonvulsantsBridged-Ring CompoundsConvulsantsganaxolonePregnanolonetetramethylenedisulfotetramineGABAA receptorneuroactive steroidpharmacokineticsrefractory status epilepticusseizuretetramethylenedisulfotetramine

Identifiers

PMID29453777
PMCPMC6910080
OpenAlexW2790816736

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.