ArticleJournal of cardiovascular translational research2018
Effect of Aerobic Exercise on Treg and Th17 of Rats with Ischemic Cardiomyopathy.
Article in Journal of cardiovascular translational research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
20 citing papers in PubMed, 28 citations in OpenAlex.
- Yoga maintains Th17/Treg cell homeostasis and reduces the rate of T cell aging in rheumatoid arthritis: a randomized controlled trial.Scientific reports · 2023Trial
- Diagnostic role of plasma biomarkers in early myocardial injury due to carbon monoxide poisoning.Internal and emergency medicine · 2025Article
- Impact of exercise on immune cell infiltration in muscle tissue: implications for muscle repair and chronic disease.Clinical and experimental medicine · 2025Review
- The clinical significance of T-cell regulation in hypertension treatment.Frontiers in immunology · 2025Review
- Diagnostic value of the creatine kinase-MB/creatine kinase and neutrophil/lymphocyte ratios in acute myocardial infarction.Journal of cardiothoracic surgery · 2024Article
- Androgen-Induced Cardiovascular Risk in Polycystic Ovary Syndrome: The Role of T Lymphocytes.Life (Basel, Switzerland) · 2023Review
- Identification of Shared Immune Cells and Immune-Related Co-Disease Genes in Chronic Heart Failure and Systemic Lupus Erythematosus Based on Transcriptome Sequencing.Journal of inflammation research · 2023Article
- Targeting regulatory T cells for cardiovascular diseases.Frontiers in immunology · 2023Review
- Exploration of the molecular targets and mechanisms of suxiao xintong dropping pills for myocardial infarction by network pharmacology method.Bioscience reports · 2021Article
- Unlocking the Role of Exercise on CD4+ T Cell Plasticity.Frontiers in immunology · 2021Article
- Regulatory T Cells in Chronic Heart Failure.Frontiers in immunology · 2021Review
- Alterations in the mucosal immune system by a chronic exhausting exercise in Wistar rats.Scientific reports · 2020Article
- Exercise-mediated regulation of autophagy in the cardiovascular system.Journal of sport and health science · 2020Review
- Exercise and Cystic Fibrosis.Advances in experimental medicine and biology · 2020Review
- Exploring Molecular Mechanism of Huangqi in Treating Heart Failure Using Network Pharmacology.Evidence-based complementary and alternative medicine : eCAM · 2020Article
- Exercise and Hyperlipidemia.Advances in experimental medicine and biology · 2020Review
- Exercise and Osteoarthritis.Advances in experimental medicine and biology · 2020Review
- Exercise and Organ Cross Talk.Advances in experimental medicine and biology · 2020Review
- Exercise during transition from compensated left ventricular hypertrophy to heart failure in aortic stenosis rats.Journal of cellular and molecular medicine · 2019Article
- Association of levels of interleukin 17 and T-helper 17 count with symptom severity and etiology of chronic heart failure: a case-control study.Croatian medical journal · 2018Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
9 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Immune activation and inflammation participate in the progression of chronic heart failure (CHF). Th17 cells and CD4+CD25+ regulatory T (Treg) cells both come from naive Th cells and share reciprocal development pathways but exhibit opposite effects. We hypothesized that the Th17/Treg balance was impaired in patients with CHF, and exercise can improve it. Rats with ischemic cardiomyopathy were prepared by ligaturing the left anterior descending branch of the left coronary artery. Rats in training group were trained with treadmill; Th17 cells increased significantly while Treg cells significantly decreased in s by flow cytometry, and the peripheral blood level of IL-6, IL-17, and TNF-α was obviously elevated by ELISA assay. We found that Th17/Treg balance is impaired in CHF rats, suggesting Th17/Treg imbalance potentially plays a role in the pathogenesis of CHF. Exercise can improve Th17/Treg imbalance, which also improves cardiac function of CHF.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.