Evidence map›Paper›PMID 29453733›Full record

ArticleTransgenic research2018

EGFP transgene: a useful tool to track transplanted bone marrow mononuclear cell contribution to peripheral remyelination.

Gonzalo Piñero, Vanina Usach, Paula A Soto, Paula V Monje, Patricia Setton-Avruj

Open access · bronzeAbstract read
PubMed Publisher
In one paragraph

Article in Transgenic research, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed, 1 pooled it
0.7field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 1 synthesis or guideline pooled it, 13 citations in OpenAlex.

  1. Pooled it
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  5. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Gonzalo PiñeroCONICET, Instituto de Química y Fisicoquímica Biológicas Prof. Alejandro C. Paladini (IQUIFIB), Universidad de Buenos Aires, Buenos Aires, Argentina.ORCID 0000-0001-8510-9598
Vanina UsachCONICET, Instituto de Química y Fisicoquímica Biológicas Prof. Alejandro C. Paladini (IQUIFIB), Universidad de Buenos Aires, Buenos Aires, Argentina.
Paula A SotoCONICET, Instituto de Química y Fisicoquímica Biológicas Prof. Alejandro C. Paladini (IQUIFIB), Universidad de Buenos Aires, Buenos Aires, Argentina.
Paula V MonjeThe Miami Project to Cure Paralysis and the Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.
Patricia Setton-AvrujCONICET, Instituto de Química y Fisicoquímica Biológicas Prof. Alejandro C. Paladini (IQUIFIB), Universidad de Buenos Aires, Buenos Aires, Argentina. setton@qb.ffyb.uba.ar.
Consejo Nacional de Investigaciones Científicas y Técnicas · ARUniversity of Miami · US

Funding

Ministerio de Ciencia, Tecnología e Innovación Productiva CONICET PIP567Ministerio de Ciencia, Tecnología e Innovación Productiva CONICET PIP830Universidad de Buenos Aires UBACYT 20020100101017
6 · The paper itself

Abstract

Bone marrow mononuclear cells (BMMC) constitute a heterogeneous population with potential to promote tissue regeneration. For this reason, this cell fraction has recently become a therapeutic alternative to mesenchymal stem cells, as culture is not required and phenotypic transformations can be hence avoided. In this work, and in order to attain long-lasting cell labeling and study longer survival times, we used BMMC isolated from adult transgenic rats expressing GFP to reproduce our wild type model and evaluate their remyelination ability in a reversible model of Wallerian degeneration. RT-PCR and flow cytometry analysis confirmed that cells isolated from the transgenic strain exhibited similar expression levels of markers specific to multipotent progenitors (CD34, CD90 and CD105) and Schwann cells (MPZ, MBP, S100β and p75

Indexed as

Bone Marrow TransplantationAnimalsAnimals, Genetically ModifiedBone Marrow CellsCell LineageCell TrackingFlow CytometryGene Expression RegulationGreen Fluorescent ProteinsHumansLeukocytes, MononuclearRatsRemyelinationSchwann CellsTransgenesWallerian Degenerationenhanced green fluorescent proteinGreen Fluorescent ProteinsBone marrow mononuclear cellsRemyelinationSciatic nerve injuryTransplantation

Identifiers

PMID29453733
OpenAlexW2791456912

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.