Evidence map›Paper›PMID 29453702›Full record

ArticleEuropean journal of nuclear medicine and molecular imaging2018

The relationship between local recurrences and distant metastases in prostate cancer: can

Giampiero Giovacchini, Andrea Ciarmiello, Elisabetta Giovannini, Andrei Fodor, Cesare Cozzarini, Paola Mapelli, Elena Incerti, Nadia Di Muzio, Luigi Gianolli, Maria Picchio

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Article in European journal of nuclear medicine and molecular imaging, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Giampiero GiovacchiniDepartment of Nuclear Medicine, S. Andrea Hospital, La Spezia, Italy.
Andrea CiarmielloDepartment of Nuclear Medicine, S. Andrea Hospital, La Spezia, Italy.
Elisabetta GiovanniniDepartment of Nuclear Medicine, S. Andrea Hospital, La Spezia, Italy.
Andrei FodorDepartment of Radiation Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Cesare CozzariniDepartment of Radiation Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Paola MapelliDepartment of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.
Elena IncertiDepartment of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.
Nadia Di MuzioDepartment of Radiation Therapy, IRCCS San Raffaele Scientific Institute, Milan, Italy.
Luigi GianolliDepartment of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy.
Maria PicchioDepartment of Nuclear Medicine, IRCCS San Raffaele Scientific Institute, Via Olgettina, 60, 20132, Milan, Italy. picchio.maria@hsr.it.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposePrevious studies in prostate cancer (PCa) patients tried to correlate the onset of local recurrence (LR) with the development of distant metastases and formulated, based on theoretical and experimental data, hypotheses linking the two events. We aimed to address this issue with

methodsThis retrospective study included 491 PCa patients previously treated with radical prostatectomy who had undergone

resultsSeventy-two patients (14.7%) had evidence of LR at

conclusionWe found no differences in the rates of lymph node and bone metastases between patients with and without LR. An inverse time-dependent trend was observed in the frequency of LR on one side and of lymph node and bone metastases on the other side. These findings were discussed in relation to previous theories linking LR to distant metastases and our study design.

Indexed as

Positron Emission Tomography Computed TomographyAgedAged, 80 and overCarbon RadioisotopesCholineHumansMaleMiddle AgedNeoplasm MetastasisNeoplasm Recurrence, LocalPositron-Emission TomographyProstate-Specific AntigenProstatic NeoplasmsRetrospective StudiesTomography, X-Ray ComputedCarbon-11Carbon RadioisotopesCholineProstate-Specific Antigen11C-cholineBiochemical failureDistant metastasesLocal recurrencePositron emission tomography/computed tomographyProstate cancer

Identifiers

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.