Evidence map›Paper›PMID 29453690›Full record

SynthesisWorld journal of urology2018

The effectiveness of targeted relative to empiric prophylaxis on infectious complications after transrectal ultrasound-guided prostate biopsy: a meta-analysis.

Susan Scott, Patrick N Harris, Deborah A Williamson, Michael A Liss, Suhail A R Doi, Matthew J Roberts

Abstract readMeta-Analysis
PubMed Publisher
In one paragraph

Synthesis in World journal of urology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
4.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 46 citations in OpenAlex.

  1. Trial
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  10. Clinical case reports · 2022
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  16. Observational
  17. Phenotypic screening for quinolone resistance in Escherichia coli.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Article
  18. Infection Prophylaxis in Urological Diagnostic and Surgical Procedures - A narrative review and recommendations.International braz j urol : official journal of the Brazilian Society of Urology
    Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 4 institutions in 3 countries.

Susan ScottFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Patrick N HarrisFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia.
Deborah A WilliamsonMicrobiological Diagnostic Unit Public Health Laboratory, Department of Microbiology & Immunology, The University of Melbourne at The Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.
Michael A LissDepartment of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX, USA.
Suhail A R DoiDepartment of Population Medicine, College of Medicine, Qatar University, Doha, Qatar.
Matthew J RobertsFaculty of Medicine, The University of Queensland, Brisbane, QLD, Australia. m.roberts2@uq.edu.au.ORCID http://orcid.org/0000-0003-0552-7402
The University of Queensland · AUQatar University · QAThe University of Melbourne · AUThe University of Texas Health Science Center at San Antonio · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeRectal culture screening for fluoroquinolone (FQ)-resistant Enterobacteriaceae before transrectal ultrasound guided prostate (TRUSPB) biopsy and targeted antibiotic prophylaxis (TAP) may decrease post-TRUSPB infection rates compared to empiric (EAP) regimens. The objective of this study was to evaluate the effectiveness of targeted relative to empiric prophylaxis regimens on rates of infectious complications after TRUSPB and to determine the baseline prevalence of FQ resistance based on prior rectal swabs.

methodsAn electronic search within literature databases including EMBASE and Web of Science (all databases) for articles assessing TAP as an approach to TRUSPB prophylaxis was conducted. Quality assessment was performed using the Hoy instrument. Meta-analysis was performed using MetaXL 5.3.

resultsFrom 15 studies (eight retrospective and seven prospective) representing 12,320 participants, infectious complication incidence was 3.4% in EAP and 0.8% in TAP patients. The number needed to treat with TAP to avoid one more infection when compared to the EAP group was 39. Effect sizes were homogeneous. Prevalence of FQ resistance showed low (15%) and high (28%) subgroups, likely due to region of origin (within and outside USA, respectively).

conclusionsRectal culture prior to TRUSPB and use of TAP adjusts for endemic FQ resistance and is associated with less infectious complications and resulting morbidity when compared to EAP. Overtreatment associated with augmented prophylaxis approaches may be reduced as a result. Further prospective assessment and cost-benefit analyses are required before widespread implementation can be recommended.

Indexed as

Anti-Bacterial AgentsAntibiotic ProphylaxisBacterial InfectionsEndoscopic Ultrasound-Guided Fine Needle AspirationFluoroquinolonesHumansIncidenceMalePrevalenceProspective StudiesProstateRectumRetrospective StudiesAnti-Bacterial AgentsFluoroquinolonesFluoroquinolone resistanceProphylaxisProstate biopsyRectal cultureSymptomatic infection

Identifiers

PMID29453690
OpenAlexW2788799537

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.