Evidence map›Paper›PMID 29453651›Full record

ReviewCurrent allergy and asthma reports2018

Neurotrophins in Asthma.

Juliana Barrios, Xingbin Ai

Abstract readReview
In one paragraph

Review in Current allergy and asthma reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.

0numbers the graph read from it
0cells of the map it votes in
17citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

17 citing papers in PubMed, 32 citations in OpenAlex.

  1. Article
  2. Effects ofPreventive nutrition and food science · 2026
    Article
  3. Review
  4. Article
  5. Article
  6. Functional role of glial-derived neurotrophic factor in a mixed allergen murine model of asthma.American journal of physiology. Lung cellular and molecular physiology · 2024
    Article
  7. Article
  8. Article
  9. Nerve Growth Factor: A Potential Therapeutic Target for Lung Diseases.International journal of molecular sciences · 2021
    Review
  10. Article
  11. Article
  12. Brain-Derived Neurotrophic Factor Inhibits the Wound-Healing and Cell Proliferative Ability of Human Airway Epithelial Cells in Asthmatic Children.Medical science monitor : international medical journal of experimental and clinical research · 2020
    Article
  13. Cholinergic neuroplasticity in asthma driven by TrkB signaling.FASEB journal : official publication of the Federation of American Societies for Experimental Biology · 2020
    Article
  14. Article
  15. Review
  16. Article
  17. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 2 institutions in 1 country.

Juliana BarriosThe Pulmonary Center, Department of Medicine, Boston University School of Medicine, Boston, MA, 02118, USA.
Xingbin AiDivision of Pulmonary and Critical Care Medicine, Brigham & Women's Hospital, Boston, MA, 02115, USA. xai@bwh.harvard.edu.
Boston University · USBrigham and Women's Hospital · US

Funding

BIOLOGY OF THE LUNG--MULTIDISCIPLINARY PROGRAMT32HL007035 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI Darrell N. Kotton, JOSEPH P MIZGERD · 1985 to 2026
$24.3M
The Fetal Lung Mesothelial Differentiation ProgramR01HL116163 · NHLBI · BOSTON UNIVERSITY MEDICAL CAMPUS · PI AI, XINGBIN, FINE, ALAN FINE · 2013 to 2016
$2.3M
Development of PNEC innervation and neuroplasticity after early life insultR01HL132991 · NHLBI · MASSACHUSETTS GENERAL HOSPITAL · PI AI, XINGBIN · 2017 to 2020
$1.8M
A function of the neuroendocrine system in mucous hyperplasiaF31HL126443 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI BARRIOS, JULIANA BEVERLY · 2015 to 2017
$76k
NHLBI NIH HHS F31 HL126443NHLBI NIH HHS R01 HL116163NHLBI NIH HHS R01 HL132991NHLBI NIH HHS T32 HL007035
6 · The paper itself

Abstract

purpose of reviewAsthma is a chronic airway disease that affects more than 300 million people worldwide. Current treatment focuses on symptomatic relief by temporally dampening inflammation and relaxing the airway. Novel combative strategies against asthma and hopefully a cure are yet to be developed. The goal of this review is to summarize recent literature on neurotrophins (NTs) in experimental models and clinical settings of asthma research. RECENT

findingsWe highlight studies of early phases of asthma that collectively reveal a profound impact of elevated NT levels following initial detrimental insults on long-term airway dysfunction. We hope this review will foster insights into the complex interaction between NTs, nerves, immune cells, and airway structural cells during a critical time window of development and disease susceptibility. Future studies are required to better understand the role of NTs in asthma pathophysiology and to evaluate whether NTs and their receptors may serve as new drug targets.

Indexed as

AnimalsAsthmaBrain-Derived Neurotrophic FactorHumansNerve Growth FactorsBrain-Derived Neurotrophic FactorNerve Growth FactorsAsthmaBrain-derived neurotrophic factorNerve growth factorNeurotrophin 4Neurotrophins

Identifiers

PMID29453651
PMCPMC5931370
OpenAlexW2794154238

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.