ArticleSleep & breathing = Schlaf & Atmung2018
Effect of semi-rapid maxillary expansion in children with obstructive sleep apnea syndrome: 5-month follow-up study.
Article in Sleep & breathing = Schlaf & Atmung, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
12 citing papers in PubMed, 1 synthesis or guideline pooled it, 33 citations in OpenAlex.
- The effect of rapid maxillary expansion on children with obstructive sleep apnea: a systematic review and meta-analysis.Sleep & breathing = Schlaf & Atmung · 2026Pooled it
- The Orthodontist in Pediatric Sleep-Disordered Breathing: A Systematic Review and Clinical Practice Framework.Cureus · 2026Review
- Controlled Prospective Evidence of Rapid Maxillary Expansion Efficacy in Pediatric Obstructive Sleep Apnea: A Systematic Review Update.Journal of clinical medicine · 2026Review
- Efficacy comparison between dentofacial orthopedic treatment and adenotonsillectomy on children with obstructive sleep apnea and skeletal class II malocclusion: a retrospective study.BMC oral health · 2025Article
- Changes in Upper Airway Airflow After Rapid Maxillary Expansion Beyond the Peak Period of Adenoidal Growth-A CBCT Study Using Computer Fluid Dynamics and Considering Adenoidal Dimensions as a Factor.Dentistry journal · 2025Article
- Feasibility of 3 Tesla MRI for the assessment of mid-palatal suture maturation: a retrospective pilot study.Odontology · 2025Article
- Review
- Medical Treatment of Obstructive Sleep Apnea in Children.Journal of clinical medicine · 2023Review
- Effects of Twin-Block Appliance Therapy on Urinary Leukotriene E4 and Serum C-Reactive Protein Levels in Obstructive Sleep Apnea Children with Class II Malocclusion and Mandibular Retrognathia: A Prospective Longitudinal Study.Indian journal of pediatrics · 2023Article
- Rapid Maxillary Expansion (RME): An Otolaryngologic Perspective.Journal of clinical medicine · 2022Review
- The relation of severe malocclusion to patients' mental and behavioral disorders, growth, and speech problems.European journal of orthodontics · 2021Article
- Computational Fluid Dynamics Analysis of Nasal Airway Changes after Treatment with C-Expander.Applied bionics and biomechanics · 2021Article
Corrections and comments
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Authors and funding
5 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe purpose of this study was to investigate the effect of semi-rapid maxillary expansion (SRME) orthodontic treatment on biomarkers and respiratory parameters in children with obstructive sleep apnea syndrome (OSAS) and maxillary transverse deficiency.
methodsThirty children with OSAS were included in this study. Fifteen children were enrolled as control, and 15 children were subjected to SRME orthodontic treatment method for 5 months. Beside respiratory parameters, pharyngeal area, dental arch, and postero-anterior widths and the levels of OSAS biomarkers in serum and urine were measured.
resultsPharyngeal airway space, dental arch, and postero-anterior widths were increased after SRME treatment. Sleep tests showed a decrease in the apnea-hypopnea index (AHI) after 5-month control/treatment duration. Serum kallikrein (KLK)1 levels decreased significantly in the treatment group. There was a significant increase in serum orosomucoid (ORM)2 levels and a decrease in urine perlecan levels in the control group after a 5-month follow-up. A significant negative correlation between serum ORM2, perlecan, gelsolin, and KLK1 levels and intercanin width, as well as between serum ORM2 and KLK1 levels and intermolar width, was observed.
conclusionsSRME treatment can be considered as a useful approach in children with OSAS. A further investigation of OSAS-related biomarkers and their relationship with sleep and orthodontic parameters is needed for providing easier and reliable modulatory strategies in the treatment of OSAS.
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Registered trials
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