ArticleNatural products and bioprospecting2018
In Vitro Antioxidant and Cytotoxic Activities of 18 Plants from the Erkowit Region, Eastern Sudan.
Article in Natural products and bioprospecting, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.
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Who cites it
7 citing papers in PubMed.
- LC-MS Profiling and Biological Activity of UnexploredPlants (Basel, Switzerland) · 2026Article
- Mitigating potential of Malva parviflora leaves against Polyram DF (dry flowable) toxicity in Nile tilapia: immune/apoptotic markers, biochemical, antioxidant, and histopathological insights.Fish physiology and biochemistry · 2025Article
- How to assess antioxidant activity? Advances, limitations, and applications of in vitro, in vivo, and ex vivo approaches.Food production, processing and nutrition · 2025Review
- The geranium genus: A comprehensive study on ethnomedicinal uses, phytochemical compounds, and pharmacological importance.Saudi journal of biological sciences · 2024Review
- A Review of the Popular Uses, Anatomical, Chemical, and Biological Aspects of Kalanchoe (Crassulaceae): A Genus of Plants Known as "Miracle Leaf".Molecules (Basel, Switzerland) · 2023Review
- Antiproliferative and cytotoxic activity of Geraniaceae plant extracts against five tumor cell lines.Future science OA · 2022Article
- New Adenosine Derivatives fromMolecules (Basel, Switzerland) · 2021Article
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Authors and funding
7 authors.
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Abstract
We investigated the antioxidant potential and cytotoxicity towards human CCRF-CEM leukemia cells of 57 extracts obtained from 18 plants collected in the Erkowit region, eastern Sudan. The antioxidant activity was determined by measuring the radical scavenging effects against 2,2-diphenyl-1-picrylhydrazyl (DPPH) and N,N-dimethyl-p-phenylendiamine (DMPD), metal-chelation capacity, ferric-reducing (FRAP) and phosphomolibdenum-reducing antioxidant power (PRAP) methods using ELISA microtiter assays. Total phenol and flavonoid amounts of the extracts were determined spectrophotometrically. Cytotoxicity towards CCRF-CEM cells was evaluated by the resazurin reduction assay. Geranium favosum followed by Kalanchoe glaucescens, Malva parviflora, Aizoon canariense, and Coleus barbatus, respectively, possessed the highest antioxidant activity among the studied plants. Chrozophora oblongifolia and K. glaucescens exerted considerable cytotoxicity against CCRF-CEM leukemia cells. These plants may serve as source for the further development of natural antioxidant and antitumor agents.
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