Evidence map›Paper›PMID 29453608›Full record

ArticleMolecular and cellular biochemistry2018

Chemopreventive action of Imatinib, a tyrosine kinase inhibitor in the regulation of angiogenesis and apoptosis in rat model of lung cancer.

Kulvinder Kumar, Preety Ghanghas, S N Sanyal

Abstract read
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In one paragraph

Article in Molecular and cellular biochemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 7 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Kulvinder KumarDepartment of Biophysics, Panjab University, Chandigarh, 160014, India.
Preety GhanghasDepartment of Biophysics, Panjab University, Chandigarh, 160014, India.
S N SanyalDepartment of Biophysics, Panjab University, Chandigarh, 160014, India. sanyalpu@gmail.com.
Panjab University · IN

Funding

Indian Council of Medical Research 3/2/2/83/2011/NCD-III]
6 · The paper itself

Abstract

The present study explored the events of angiogenesis and apoptosis in 7,12-dimethyl benz(a)anthracene (DMBA)-induced lung cancer in rat and its chemoprevention with Imatinib, a receptor tyrosine kinase inhibitor. Further, it includes  lipopolysaccharide (LPS) mediating inflammation along with DMBA for the promotion of lung carcinogenesis. The animals received a single intratracheal instillation of DMBA (20 mg/kg body weight) in olive oil and LPS (0.6 mg/kg body weight) to induce tumors in 16 weeks. Besides morphology and histology of the lung tissues, RT-PCR, western blots, and immunofluorescence were performed for the expression of apoptotic and angiogenic proteins. Apoptosis was studied by mitochondrial Bcl-2/Bax ratio and staining with the dyes Acridine orange/ethidium bromide of the isolated Broncho epithelial cells. Also, mitochondrial membrane potential (ΔΨ

Indexed as

Lung NeoplasmsNeoplasms, ExperimentalNeovascularization, Pathologic9,10-Dimethyl-1,2-benzanthraceneAnimalsApoptosisFemaleImatinib MesylateInflammationLipopolysaccharidesNeoplasm ProteinsProtein Kinase InhibitorsRatsRats, Sprague-Dawley9,10-Dimethyl-1,2-benzanthraceneImatinib MesylateLipopolysaccharidesNeoplasm ProteinsProtein Kinase InhibitorsAngiogenesisApoptosisDMBAImatinibLPS

Identifiers

PMID29453608
OpenAlexW2790155550

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.