ArticleClinical oral investigations2018
Bone mineralization and vascularization in bisphosphonate-related osteonecrosis of the jaw: an experimental study in the rat.
Article in Clinical oral investigations, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 44 citations in OpenAlex.
- Fermentation Time Modulates the Osteoprotective Effects of Milk Kefir in Glucocorticoid-Induced Osteoporotic Rats.Molecular nutrition & food research · 2026Article
- Micro/nano-structured titanium surfaces promote endothelial responses and angiogenic activity under zoledronic acid exposure.BMC oral health · 2026Article
- Current challenges and emerging solutions in dentistry for treating medication-related osteonecrosis of the jaw (MRONJ): the state of the art in the era of personalized medicine.Einstein (Sao Paulo, Brazil) · 2026Review
- Genetic Background of Medication-Related Osteonecrosis of the Jaw: Current Evidence and Future Perspectives.International journal of molecular sciences · 2024Review
- Article
- Polysacharide of Agaricus blazei gel mitigates bone necrosis in model of the jaws related to bisphosphonate via Wnt signaling.Scientific reports · 2024Article
- Exosome-targeted delivery of METTL14 regulates NFATc1 m6A methylation levels to correct osteoclast-induced bone resorption.Cell death & disease · 2023Article
- Influence of antiresorptive/antiangiogenic therapy on the surgical treatment outcomes of experimentally induced peri-implantitis lesions.Clinical oral investigations · 2023Article
- Sildenafil reduces bisphosphonate-induced jaw osteonecrosis in rats.Clinical oral investigations · 2023Article
- The feasibility of discriminating BRONJ lesion bone with Raman spectroscopy.Frontiers in endocrinology · 2023Article
- Computed tomography bone density variations in oncological patients undergoing antiresorptive medication.Medicina oral, patologia oral y cirugia bucal · 2022Article
- PCA-Assisted Raman Analysis of Osteonecrotic Human Femoral Heads.Methods and protocols · 2022Article
- Review
- Engineered osteoclasts resorb necrotic alveolar bone in anti-RANKL antibody-treated mice.Bone · 2021Article
- Small Extracellular Vesicles Derived from Adipose Tissue Prevent Bisphosphonate-Related Osteonecrosis of the Jaw by Promoting Angiogenesis.International journal of nanomedicine · 2021Article
- In vivo quantification of mandibular bone remodeling and vascular changes in a Wistar rat model: A novel HR-MRI and micro-CT fusion technique.Imaging science in dentistry · 2020Article
- Article
- Extensive protein expression changes induced by pamidronate in RAW 264.7 cells as determined by IP-HPLC.PeerJ · 2020Article
- From Osteoclast Differentiation to Osteonecrosis of the Jaw: Molecular and Clinical Insights.International journal of molecular sciences · 2019Review
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5 authors at 2 institutions in 1 country.
Funding
Abstract
objectivesPathogenesis of bisphosphonate-related osteonecrosis of the jaws (BRONJ) is not fully explained. An antiangiogenic effect of bisphosphonates (BPs) or an altered bone quality have been advocated. The aims of the present study were to analyze alveolar mandibular vascularization and bone quality in rats with BRONJ. MATERIALS AND
methodsThirty-eight Sprague-Dawley rats were randomized into two groups: zoledronic acid (ZA), n = 27, and control (CTRL) n = 11. The ZA group received a weekly IV injection of ZA (100 μg/kg) during 10 weeks. The CTRL group received saline. After 6 weeks, extraction of the right mandibular molars was performed. Rats were sacrificed after 14 weeks. Microtomography characterized bone lesions and vascularization after injection of a radio-opaque material. Raman microspectroscopy evaluated bone mineralization.
resultsFifty-five percent of ZA rats presented bone exposure and signs of BRONJ. None sign was found at the left hemimandible in the ZA group and in the CTRL group. Vascular density appeared significantly increased in the right hemimandibles of the CTRL group compared to the left hemimandibles. Vascularization was reduced in the ZA group. A significantly increased of the mineral-to-amide ratio was found in the alveolar bone of ZA rats by Raman microspectroscopy.
conclusionsIn a rat model of BRONJ, microtomography evidenced osteonecrosis in BRONJ. Raman spectroscopy showed an increased mineralization. Vascularization after tooth extraction was impaired by ZA. CLINICAL RELEVANCE: Prolonged BP administration caused an increase in the mineralization and a quantitative reduction of the vascularization in the alveolar bone; both factors might be involved concomitantly in the BRONJ pathophysiology.
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