Evidence map›Paper›PMID 29453461›Full record

ArticleInternational journal of obesity (2005)2019

Roux-en-Y Gastric-Bypass and sleeve gastrectomy induces specific shifts of the gut microbiota without altering the metabolism of bile acids in the intestinal lumen.

Henri Duboc, Caroline Chong Nguyen, Jean-Baptiste Cavin, Lara Ribeiro-Parenti, Anne-Charlotte Jarry, Dominique Rainteau, Lydie Humbert, Benoit Coffin, Maude Le Gall, André Bado and 1 more

Abstract read
PubMed Publisher
In one paragraph

Article in International journal of obesity (2005), 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Article
  7. Connection between gut microbiome and the development of obesity.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2019
    Review
  8. Review
  9. Review
  10. Review
  11. Review
  12. Review
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Henri DubocINSERM UMR 1149, University Paris Diderot, Sorbonne Paris Cité and DHU Unity, APHP, Paris, F-75890, France. henri.duboc@aphp.fr.
Caroline Chong NguyenINSERM UMR 1149, University Paris Diderot, Sorbonne Paris Cité and DHU Unity, APHP, Paris, F-75890, France.
Jean-Baptiste CavinINSERM UMR 1149, University Paris Diderot, Sorbonne Paris Cité and DHU Unity, APHP, Paris, F-75890, France.
Lara Ribeiro-ParentiINSERM UMR 1149, University Paris Diderot, Sorbonne Paris Cité and DHU Unity, APHP, Paris, F-75890, France.
Anne-Charlotte JarryINSERM UMR 1149, University Paris Diderot, Sorbonne Paris Cité and DHU Unity, APHP, Paris, F-75890, France.
Dominique RainteauSorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, APHP, Laboratoire des Biomolécules (LBM), 27 rue de Chaligny, Paris, 75005, France.
Lydie HumbertSorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, APHP, Laboratoire des Biomolécules (LBM), 27 rue de Chaligny, Paris, 75005, France.
Benoit CoffinDepartment of Hepato Gastro Enterology, Louis Mourier Hospital, APHP, University Paris Diderot, Sorbonne Paris Cité and DHU Unity, Paris, France.
Maude Le GallINSERM UMR 1149, University Paris Diderot, Sorbonne Paris Cité and DHU Unity, APHP, Paris, F-75890, France.ORCID http://orcid.org/0000-0002-5372-4585
André BadoINSERM UMR 1149, University Paris Diderot, Sorbonne Paris Cité and DHU Unity, APHP, Paris, F-75890, France.
Harry SokolSorbonne Universités, UPMC Univ. Paris 06, École normale supérieure, PSL Research University, CNRS, INSERM, APHP, Laboratoire des Biomolécules (LBM), 27 rue de Chaligny, Paris, 75005, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Some shifts in the gut microbiota composition and its metabolic fingerprints have been associated to Sleeve gastrectomy (SG) and Roux-en-Y Gastric Bypass (RYGB). So far, plasma bile acids have been associated with post-operative glucose improvement and weight loss, but nothing is known about their metabolism in the gut lumen. As bile acids are physiologically transformed by the microbiota into various species, the aim of this work was to study how SG and RYGB-associated dysbiosis impact the bioconversion of bile acids in the intestinal lumen. Comparing SHAM (n = 9) with our validated rat models of SG (n = 5) and RYGB (n = 6), we quantified luminal bile acids along the gut and found that the metabolic transformation of bile acids (deconjugation, dehydroxylation, and epimerization) is not different from the duodenum to the colon. However, in the cecum where the biotransformation mainly takes place, we observed deep alterations of the microbiota composition, which were specific of each type of surgery. In conclusion, despite specific dysbiosis after surgery, the bile acids metabolism in the gut lumen is highly preserved, suggesting that a resilience of the gut microbiota occurs after these procedures.

Indexed as

GastrectomyGastric BypassAnimalsBile Acids and SaltsGastrointestinal MicrobiomeObesity, MorbidRatsRats, WistarBile Acids and Salts

Identifiers

PMID29453461

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.