ArticleScientific reports2018
Temporal structure in spiking patterns of ganglion cells defines perceptual thresholds in rodents with subretinal prosthesis.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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Who cites it
17 citing papers in PubMed.
- Photovoltaic Restoration of Central Vision in Atrophic Age-Related Macular Degeneration.Ophthalmology · 2020Trial
- Inkjet-Printed Rough Gold Microelectrode Arrays on Flexible Substrates for Neural Recording and Electrical Stimulation.ACS applied materials & interfaces · 2026Article
- Simulation of prosthetic vision with the PRIMA system and enhancement of face representation.Journal of neuroengineering and rehabilitation · 2026Article
- Restoration of Sight with Electronic Retinal Prostheses.Annual review of vision science · 2025Review
- Assessment of visual function in blind mice and monkeys with subretinally implanted nanowire arrays as artificial photoreceptors.Nature biomedical engineering · 2024Article
- Prosthetic Visual Acuity with the PRIMA System in Patients with Atrophic Age-related Macular Degeneration at 4 years follow-up.medRxiv : the preprint server for health sciences · 2023Article
- Emerging trends in the development of flexible optrode arrays for electrophysiology.APL bioengineering · 2023Review
- Electronic Retinal Prostheses.Cold Spring Harbor perspectives in medicine · 2023Review
- Long-term observations of macular thickness after subretinal implantation of a photovoltaic prosthesis in patients with atrophic age-related macular degeneration.Journal of neural engineering · 2022Article
- Photovoltaic implant simulator reveals resolution limits in subretinal prosthesis.Journal of neural engineering · 2022Article
- On optimal coupling of the 'electronic photoreceptors' into the degenerate retina.Journal of neural engineering · 2020Article
- Cortical Interactions between Prosthetic and Natural Vision.Current biology : CB · 2020Article
- PRIMA subretinal wireless photovoltaic microchip implantation in non-human primate and feline models.PloS one · 2020Article
- Performance of complex visual tasks using simulated prosthetic vision via augmented-reality glasses.Journal of vision · 2019Article
- STEM CELL THERAPIES, GENE-BASED THERAPIES, OPTOGENETICS, AND RETINAL PROSTHETICS: Current State and Implications for the Future.Retina (Philadelphia, Pa.) · 2019Review
- Photogenerated Electrical Fields for Biomedical Applications.Frontiers in bioengineering and biotechnology · 2018Review
- Prosthetic Visual Acuity with the PRIMA Subretinal Microchip in Patients with Atrophic Age-Related Macular Degeneration at 4 Years Follow-up.Ophthalmology scienceArticle
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Authors and funding
9 authors.
Funding
Abstract
Subretinal prostheses are designed to restore sight in patients blinded by retinal degeneration using electrical stimulation of the inner retinal neurons. To relate retinal output to perception, we studied behavioral thresholds in blind rats with photovoltaic subretinal prostheses stimulated by full-field pulsed illumination at 20 Hz, and measured retinal ganglion cell (RGC) responses to similar stimuli ex-vivo. Behaviorally, rats exhibited startling response to changes in brightness, with an average contrast threshold of 12%, which could not be explained by changes in the average RGC spiking rate. However, RGCs exhibited millisecond-scale variations in spike timing, even when the average rate did not change significantly. At 12% temporal contrast, changes in firing patterns of prosthetic response were as significant as with 2.3% contrast steps in visible light stimulation of healthy retinas. This suggests that millisecond-scale changes in spiking patterns define perceptual thresholds of prosthetic vision. Response to the last pulse in the stimulation burst lasted longer than the steady-state response during the burst. This may be interpreted as an excitatory OFF response to prosthetic stimulation, and can explain behavioral response to decrease in illumination. Contrast enhancement of images prior to delivery to subretinal prosthesis can partially compensate for reduced contrast sensitivity of prosthetic vision.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.