ArticleNeuropsychopharmacology : official publication of the American College of Neuropsychopharmacology2018
Embryonic stem cell transplants as a therapeutic strategy in a rodent model of autism.
Article in Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- An ASXL3-thyroid hormone axis in parvalbumin interneurons controls autism-like behaviors.Science advances · 2026Article
- Rapid and Robust Generation of Human Cortical Interneurons from Induced Neural Stem Cells.International journal of molecular sciences · 2026Article
- Analysis of Gene, Environment, and Sex Interaction in the Development of Autistic-like Phenotype in Mice.International journal of molecular sciences · 2026Article
- Maternal Immune Activation Leads to Mitochondrial Dysfunction and a Social Deficit in Offspring That Is Reversed by Nicotinamide Riboside.Nutrients · 2026Article
- Stem Cell Therapy and Models for Autism Spectrum Disorder: Insights and Research.Current neuropharmacology · 2026Review
- Review
- Poly (I:C)-induced maternal immune activation generates impairment of reversal learning performance in offspring.Journal of neurochemistry · 2025Article
- Age-related changes in behavior profile in male offspring of rats treated with poly I:C-induced maternal immune activation in early gestation.Animal models and experimental medicine · 2024Article
- Application of Medial Ganglionic Eminence Cell Transplantation in Diseases Associated With Interneuron Disorders.Frontiers in cellular neuroscience · 2022Review
- iPSC toolbox for understanding and repairing disrupted brain circuits in autism.Molecular psychiatry · 2022Review
- Cortical interneurons in autism.Nature neuroscience · 2021Review
- Brain Structural and Functional Alterations in Mice Prenatally Exposed to LPS Are Only Partially Rescued by Anti-Inflammatory Treatment.Brain sciences · 2020Article
- Stem Cells for Improving the Treatment of Neurodevelopmental Disorders.Stem cells and development · 2020Review
- Developmental alterations in the transcriptome of three distinct rodent models of schizophrenia.PloS one · 2020Article
- Region specific knockdown of Parvalbumin or Somatostatin produces neuronal and behavioral deficits consistent with those observed in schizophrenia.Translational psychiatry · 2019Article
- Maternal immune activation impairs cognitive flexibility and alters transcription in frontal cortex.Neurobiology of disease · 2019Article
- Brain changes in a maternal immune activation model of neurodevelopmental brain disorders.Progress in neurobiology · 2019Review
- Cell Therapies for Autism Spectrum Disorder Based on New Pathophysiology: A Review.Cell transplantationReview
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Authors and funding
3 authors.
Funding
Abstract
Autism is a neurodevelopmental disorder characterized by disruptions in three core behavioral domains: deficits in social interaction, impairments in communication, and repetitive and stereotyped patterns of behavior or thought. There are currently no drugs available for the treatment of the core symptoms of ASD and drugs that target comorbid symptoms often have serious adverse side effects, suggesting an urgent need for new therapeutic strategies. The neurobiology of autism is complex, but converging evidence suggests that ASD involves disruptions in the inhibitory GABAergic neurotransmitter system. Specifically, people with autism have a reduction in parvalbumin (PV)-containing interneurons in the PFC, leading to the suggestion that restoring interneuron function in this region may be a novel therapeutic approach for ASD. Here we used a dual-reporter embryonic stem cell line to generate enriched populations of PV-positive interneurons, which were transplanted into the medial prefrontal cortex (mPFC) of the Poly I:C rodent model of autism. PV interneuron transplants were able to decrease pyramidal cell firing in the mPFC and alleviated deficits in social interaction and cognitive flexibility. Our results suggest that restoring PV interneuron function in the mPFC may be a novel and effective treatment strategy to reduce the core symptoms of autism.
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