ArticleScientific reports2018
Altered immunity in crowded Mythimna separata is mediated by octopamine and dopamine.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 28 citations in OpenAlex.
- Virus specific impacts on honey bee flight performance are mediated by the octopamine pathway.bioRxiv : the preprint server for biology · 2026Article
- Article
- Effects of population density on life history traits in a moth: in search of proximate and ultimate explanations.Oecologia · 2026Article
- Stress in dipteran insects mass-reared for sterile insect technique applications.Insect science · 2025Review
- Review
- Octopamine modulates the innate immune response inFrontiers in immunology · 2025Article
- Multi-Omics Reveals the Effect of Population Density on the Phenotype, Transcriptome and Metabolome ofInsects · 2023Article
- Inhibition of Dopamine Activity and Response ofJournal of fungi (Basel, Switzerland) · 2022Article
- Molecular and Pharmacological Characterization of β-Adrenergic-like Octopamine Receptors in the EndoparasitoidInternational journal of molecular sciences · 2022Article
- Immune-microbiome interplay and its implications in neurodegenerative disorders.Metabolic brain disease · 2022Review
- How Dopamine Influences Survival and Cellular Immune Response ofJournal of fungi (Basel, Switzerland) · 2021Article
- Effects of Larval Density onInsects · 2020Article
- Article
- The Role of Tyramine β-Hydroxylase in Density Dependent Immunityof Oriental Armyworm (International journal of molecular sciences · 2019Article
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Authors and funding
9 authors at 3 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Similar to pathogenic infection, high population density alters insects' prophylactic immunity. Density-dependent prophylaxis has been reported in many polyphenic insects, but the regulatory mechanism underlying this phenomenon remains unclear. The biogenic monoamines are known to play critical roles in mediating insect immune responses. In the current study, the immune capacity and the levels of three biogenic monoamines were investigated in the polyphenic larvae of Mythimna separata, reared at the densities of 1, 2, 5, 10, and 30 larvae per 650-mL jar. Concomitant with the increased phenoloxidase (PO) activity and total haemocyte count in the larvae at high densities (5, 10, 30 larvae/jar), the octopamine level was also increased. In contrast, the dopamine level was decreased, and the 5-hydroxytryptamine level was not significantly affected. Injection of octopamine induced significant increases in the total haemocyte count and PO activity. Conversely, epinastine, a specific antagonist of octopamine, decreased the total haemocyte count and PO activity. Another octopamine antagonist, phentolamine, inhibited the activity of PO and lysozymes. In addition, injection of dopamine induced a significant increase in PO activity and decreased the total haemocyte count and lysozyme activity. These results suggested that both octopamine and dopamine mediate the increases in total haemocyte count and PO activity in the crowded larvae.
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