Evidence map›Paper›PMID 29453435›Full record

ArticleJournal of perinatology : official journal of the California Perinatal Association2018

Evidence of a gene-environment interaction of NODAL variants and inflammation in preterm birth.

Lisa M Starr, Taghreed A Ayash, Daniel Dufort

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In one paragraph

Article in Journal of perinatology : official journal of the California Perinatal Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Article
  2. Article
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4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

3 authors.

Lisa M StarrDepartment of Obstetrics and Gynecology, McGill University, Montreal, QC, Canada.
Taghreed A AyashDivision of Experimental Medicine, McGill University, Montreal, QC, Canada.
Daniel DufortDepartments of Obstetrics and Gynecology and Division of Experimental Medicine, McGill University, Montreal, QC, Canada. daniel.dufort@mcgill.ca.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveNODAL has been implicated in timing of parturition and immune regulation. We investigated the relationship between NODAL polymorphisms, infection/inflammation, and preterm birth. STUDY

designFor this secondary analysis, 613 women (189 preterm and 424 term) from the Montreal Prematurity Study were genotyped for NODAL polymorphisms and assessed for bacterial vaginosis and placental inflammation.

resultNODAL polymorphisms were not associated with preterm birth. However, the rs2231947(C>T) variant allele was associated with increased risk for preterm birth among women with bacterial vaginosis (odds ratio: 2.76, 95% confidence interval: 1.12-6.85). Among women without placental inflammation, the rs1904589(A>G) variant allele was associated with increased risk of preterm birth (odds ratio: 1.31, 95% confidence interval: 1.02-1.70). Among women with placental inflammation, the rs10999338(C>T) variant allele was associated with reduced risk of preterm birth (odds ratio: 0.50, 95% confidence interval: 0.29-0.87).

conclusionThe effect of NODAL polymorphisms on preterm birth depends on maternal infection/inflammation status.

Indexed as

Gene-Environment InteractionAdolescentAdultAllelesCase-Control StudiesFemaleHumansInfant, Low Birth WeightInfant, NewbornInflammationLogistic ModelsMaleNodal ProteinObstetric Labor, PrematureOdds RatioPolymorphism, GeneticNodal ProteinNODAL protein, human

Identifiers

PMID29453435

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.