Evidence map›Paper›PMID 29453431›Full record

Trial reportNature communications2018

Delayed gut microbiota development in high-risk for asthma infants is temporarily modifiable by Lactobacillus supplementation.

Juliana Durack, Nikole E Kimes, Din L Lin, Marcus Rauch, Michelle McKean, Kathryn McCauley, Ariane R Panzer, Jordan S Mar, Michael D Cabana, Susan V Lynch

Abstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Nature communications, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 127 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
127citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

127 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Probiotics in infants for prevention of allergic disease.The Cochrane database of systematic reviews · 2025
    Pooled it
  2. Pooled it
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  7. Nutrients · 2020
    Trial
  8. Efficacy ofNutrients · 2018
    Trial
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  11. Review
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67 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Juliana DurackDivision of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Nikole E KimesDivision of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Din L LinDivision of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Marcus RauchDivision of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Michelle McKeanDivision of General Pediatrics, Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94143, USA.
Kathryn McCauleyDivision of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Ariane R PanzerDivision of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Jordan S MarDivision of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA.
Michael D CabanaDivision of General Pediatrics, Department of Pediatrics, University of California San Francisco, San Francisco, CA, 94143, USA.
Susan V LynchDivision of Gastroenterology, Department of Medicine, University of California San Francisco, San Francisco, CA, 94143, USA. susan.lynch@ucsf.edu.

Funding

Engaging University of California Stakeholders for Biorespository ResearchUL1TR000004 · NCATS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI GRANDIS, JENNIFER RUBIN · 2012 to 2015
$78.0M
PREDOCTORAL TRAINING IN BIOMEDICAL SCIENCEST32GM008568 · NIGMS · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI ANSEL, KARL MARK · 1995 to 2019
$6.3M
Probiotic Outcomes in Enteric Microflora (POEM) StudyR21AT004732 · NCCIH · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO · PI CABANA, MICHAEL D · 2009 to 2010
$374k
NCATS NIH HHS UL1 TR000004NCCIH NIH HHS R21 AT004732NIGMS NIH HHS T32 GM008568
6 · The paper itself

Abstract

Gut microbiota dysbiosis and metabolic dysfunction in infancy precedes childhood atopy and asthma development. Here we examined gut microbiota maturation over the first year of life in infants at high risk for asthma (HR), and whether it is modifiable by early-life Lactobacillus supplementation. We performed a longitudinal comparison of stool samples collected from HR infants randomized to daily oral Lactobacillus rhamnosus GG (HRLGG) or placebo (HRP) for 6 months, and healthy (HC) infants. Meconium microbiota of HRP participants is distinct, follows a delayed developmental trajectory, and is primarily glycolytic and depleted of a range of anti-inflammatory lipids at 6 months of age. These deficits are partly rescued in HRLGG infants, but this effect was lost at 12 months of age, 6 months after cessation of supplementation. Thus we show that early-life gut microbial development is distinct, but plastic, in HR infants. Our findings offer a novel strategy for early-life preventative interventions.

Indexed as

Gastrointestinal MicrobiomeImmunomodulationLacticaseibacillus rhamnosusAsthmaHumansInfantInfant, NewbornMeconiumProbioticsT-Lymphocytes, Regulatory

Identifiers

PMID29453431
PMCPMC5816017

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.