ArticleScientific reports2018
Human neutrophils can mimic myeloid-derived suppressor cells (PMN-MDSC) and suppress microbead or lectin-induced T cell proliferation through artefactual mechanisms.
Open access · goldAbstract read
In one paragraph
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
29citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 8% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
29 citing papers in PubMed, 1 synthesis or guideline pooled it, 40 citations in OpenAlex.
- Emerging Blood-Based Biomarkers for Predicting Response to Checkpoint Immunotherapy in Non-Small-Cell Lung Cancer.Frontiers in immunology · 2020Pooled it
- Natural killer cell cryopreservation: Influence of composition, temperature, and granules on post-thaw survival and function.Molecular therapy. Advances · 2026Article
- Endoplasmic reticulum stress in disease pathogenesis: its implications for therapy.Signal transduction and targeted therapy · 2026Review
- Article
- Exploring the Role of Low-Density Neutrophils DuringFrontiers in cellular and infection microbiology · 2022Review
- CD47-SIRPα Controls ADCC Killing of Primary T Cells by PMN Through a Combination of Trogocytosis and NADPH Oxidase Activation.Frontiers in immunology · 2022Article
- Antibody-Mediated LILRB2-Receptor Antagonism Induces Human Myeloid-Derived Suppressor Cells to KillFrontiers in immunology · 2022Article
- Myeloid-Derived Suppressor Cells Mediate T Cell Dysfunction in Nonhuman Primate TB Granulomas.mBio · 2021Article
- Neutrophils in cancer-unresolved questions.Science China. Life sciences · 2021Review
- Expansion of CD10eLife · 2021Article
- Mechanisms Driving Neutrophil-Induced T-cell Immunoparalysis in Ovarian Cancer.Cancer immunology research · 2021Observational
- The twilight zone: plasticity and mixed ontogeny of neutrophil and eosinophil granulocyte subsets.Seminars in immunopathology · 2021Review
- Article
- Immunosuppression in Glioblastoma: Current Understanding and Therapeutic Implications.Frontiers in oncology · 2021Review
- The Outcome of Neutrophil-T Cell Contact Differs Depending on Activation Status of Both Cell Types.Frontiers in immunology · 2021Article
- High Purity Isolation of Low Density Neutrophils Casts Doubt on Their Exceptionality in Health and Disease.Frontiers in immunology · 2021Article
- Targeting MDSC for Immune-Checkpoint Blockade in Cancer Immunotherapy: Current Progress and New Prospects.Clinical Medicine Insights. Oncology · 2021Review
- Review
- Blood collection technique, anticoagulants and storing temperature have minor effects on the isolation of polymorphonuclear neutrophils.Scientific reports · 2020Article
- Tumor-Associated Neutrophils Dampen Adaptive Immunity and Promote Cutaneous Squamous Cell Carcinoma Development.Cancers · 2020Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
14 authors at 4 institutions in 1 country.
Dmitri NegorevThe Pathology Bioresource, Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, PA, 19104, USA.
Ulf H BeierDivision of Nephrology, Department of Pediatrics, Children's Hospital of Philadelphia and University of Pennsylvania, PA, 19104, Philadelphia, USA.
Tianyi ZhangDivision of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.
Jon G QuatromoniDivision of Thoracic Surgery, Department of Surgery, University of Pennsylvania, 19104, Philadelphia, PA, USA.
Pratik BhojnagarwalaDivision of Thoracic Surgery, Department of Surgery, University of Pennsylvania, 19104, Philadelphia, PA, USA.
Steven M AlbeldaDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Sunil SinghalDivision of Thoracic Surgery, Department of Surgery, University of Pennsylvania, 19104, Philadelphia, PA, USA.
Evgeniy EruslanovDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Falk W LohoffSection on Clinical Genomics and Experimental Therapeutics, National Institute on Alcohol Abuse and Alcoholism (NIAAA), National Institutes of Health (NIH), Bethesda, MD, 20892-154, USA.
Matthew H LevineDepartment of Surgery, Penn Transplant Institute, Hospital of the University of Pennsylvania and University of Pennsylvania, Philadelphia, PA, 19104, USA.
Joshua M DiamondDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Jason D ChristieDivision of Pulmonary, Allergy and Critical Care Medicine, Department of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Wayne W HancockDivision of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA.ORCID 0000-0002-7211-5291
Tatiana AkimovaDivision of Transplant Immunology, Department of Pathology and Laboratory Medicine, Children's Hospital of Philadelphia and University of Pennsylvania, Philadelphia, PA, USA. akimovat@email.chop.edu.ORCID 0000-0003-2767-8762
University of Pennsylvania · USChildren's Hospital of Philadelphia · USHospital of the University of Pennsylvania · USNational Institutes of Health · US
Funding
Clinical Genomics and Experimental TherapeuticsZIAAA000242 · NIAAA · NATIONAL INSTITUTE ON ALCOHOL ABUSE AND ALCOHOLISM · PI LOHOFF, FALK · 2015 to 2025
$26.7MTransgenic and mutant animalP01AI073489 · NIAID · UNIVERSITY OF PENNSYLVANIA · PI KATSUMATA, MAKOTO · 2008 to 2012
$7.1MHDAC2 Inhibition Mitigates Renal Ischemia Reperfusion InjuryR01DK106243 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LEVINE, MATTHEW HOWARD · 2016 to 2020
$1.8MTumor-associated neutrophils in human lung cancerR01CA187392 · NCI · UNIVERSITY OF PENNSYLVANIA · PI ERUSLANOV, EVGENIY · 2016 to 2020
$1.8MHistone/Protein Deacetylase Inhibitors Minimize Renal Ischemia-Reperfusion InjuryK08DK092282 · NIDDK · UNIVERSITY OF PENNSYLVANIA · PI LEVINE, MATTHEW HOWARD · 2011 to 2015
$768kTargeting Sirtuin-1 to enhance Foxp3+ regulatory T-cell functionK08AI095353 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI BEIER, ULF · 2011 to 2015
$650kANTI-INFLAMMATORY EFFECTS OF TARGETING THE HDAC6/HSP90 PATHWAYR56AI095276 · NIAID · CHILDREN'S HOSP OF PHILADELPHIA · PI HANCOCK, WAYNE WILLIAM · 2011 to 2011
$209kNCI NIH HHS R01 CA187392NIAID NIH HHS K08 AI095353NIAID NIH HHS P01 AI073489NIAID NIH HHS R56 AI095276NIDDK NIH HHS K08 DK092282NIDDK NIH HHS R01 DK106243
Abstract
We report that human conventional CD15
Indexed as
MicrospheresAnimalsArtifactsCell ProliferationHumansLectinsMiceMyeloid-Derived Suppressor CellsPhenotypeT-LymphocytesLectins
Identifiers
What OpenQuestion holds
Textmetadata
LicenceCC BY
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.