Evidence map›Paper›PMID 29453428›Full record

ArticleEuropean journal of clinical nutrition2018

IGF-I and IGFBP-3 concentrations at 2 years: associations with anthropometry and milk consumption in an Indian cohort.

Andrea S Wiley, Suyog M Joshi, Himangi G Lubree, Dattatray S Bhat, Neelam S Memane, Deepa A Raut, Chittaranjan S Yajnik

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Article in European journal of clinical nutrition, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 3 syntheses or guidelines pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Andrea S WileyAnthropology Department and Human Biology Program, Indiana University, Bloomington, IN, USA. wileya@indiana.edu.
Suyog M JoshiKamalanayan Bajaj Diabetology Research Centre, KEM Hospital Research Centre, KEM Hospital, 6th floor Banoo Coyaji Building, Rasta Peth, Sardar Moodliar Road, Pune, 411011, Maharashtra, India.
Himangi G LubreeKamalanayan Bajaj Diabetology Research Centre, KEM Hospital Research Centre, KEM Hospital, 6th floor Banoo Coyaji Building, Rasta Peth, Sardar Moodliar Road, Pune, 411011, Maharashtra, India.
Dattatray S BhatKamalanayan Bajaj Diabetology Research Centre, KEM Hospital Research Centre, KEM Hospital, 6th floor Banoo Coyaji Building, Rasta Peth, Sardar Moodliar Road, Pune, 411011, Maharashtra, India.
Neelam S MemaneKamalanayan Bajaj Diabetology Research Centre, KEM Hospital Research Centre, KEM Hospital, 6th floor Banoo Coyaji Building, Rasta Peth, Sardar Moodliar Road, Pune, 411011, Maharashtra, India.
Deepa A RautKamalanayan Bajaj Diabetology Research Centre, KEM Hospital Research Centre, KEM Hospital, 6th floor Banoo Coyaji Building, Rasta Peth, Sardar Moodliar Road, Pune, 411011, Maharashtra, India.
Chittaranjan S YajnikKamalanayan Bajaj Diabetology Research Centre, KEM Hospital Research Centre, KEM Hospital, 6th floor Banoo Coyaji Building, Rasta Peth, Sardar Moodliar Road, Pune, 411011, Maharashtra, India.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

objectivesTo ascertain associations between plasma insulin-like growth factor I (IGF-I), insulin-like growth factor-binding protein 3 (IGFBP-3) and their molar ratio at 2 y with neonatal size, infant growth, body composition at 2 y, and feeding practices in an Indian cohort. SUBJECTS/

methodsA cohort of 209 newborns, with 122 followed at 2 y. Anthropometry was conducted at birth and 2 y. IGF-I and IGFBP-3 concentrations were measured in cord blood and at 2 y. Maternal and child diet was assessed by food frequency questionnaires and maternal interviews. Multivariate regression was used to test for associations adjusting for confounding factors.

resultsMean 2 y plasma IGF-I and IGFBP-3 concentrations and IGF-I/IGFBP-3 were 49.4 ng/ml (95% CI: 44.1, 54.8), 1953.8 ng/ml (CI: 1870.6, 2036.9) ng/ml, and 0.088 (CI: 0.081, 0.095), respectively. IGF-I and IGF-I/IGFBP-3 were positively associated with current length, but not body mass index or adiposity. IGF-I was higher among those with greater change in length since birth. IGF-I concentrations were higher in children who drank the most milk (>500 vs. <250 ml per day: 65.6 vs. 42.8 ng/ml, p < 0.04), received other milk <6 months compared to ≥6 months (56.3 vs. 44.8 ng/ml, p < 0.05), and in those whose mothers consumed milk daily vs. less frequently in late pregnancy (56.4 vs. 42.7 ng/ml, p < 0.01). In multivariate regression, 2 y IGF-I concentration and IGF-I/IGFBP-3 were each positively associated with current length and milk intake. IGFBP-3 was not related to anthropometry or milk intake.

conclusionsPlasma IGF-I concentrations and IGF-I/IGFBP-3 at 2 y are positively associated with length at 2 y and current milk intake.

Indexed as

MilkAnimalsAnthropometryBody HeightBody Mass IndexBreast FeedingChild, PreschoolDietFemaleFetal BloodHumansInfantInfant, NewbornInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor ILongitudinal StudiesIGF1 protein, humanIGFBP3 protein, humanInsulin-Like Growth Factor Binding Protein 3Insulin-Like Growth Factor I

Identifiers

PMID29453428

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.