ReviewMolecular psychiatry2019
Depression and obesity: evidence of shared biological mechanisms.
Review in Molecular psychiatry, 2019. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 554 papers, 8 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
554 citing papers in PubMed, 8 syntheses or guidelines pooled it, 1,019 citations in OpenAlex.
- Impact of Weight Bias, Stigma and Discrimination on Physical, Mental, and Quality of Life Outcomes of Metabolic and Bariatric Surgery: A Systematic Review.Obesity surgery · 2026Pooled it
- Association between green space exposure and elderly health: a systematic review and meta-analysis.BMC public health · 2026Pooled it
- Gut microbiota-dependent mechanisms and efficacy of natural polysaccharides in multitarget antidepressant therapy: a systematic review.Frontiers in psychiatry · 2026Pooled it
- The effects of fluoxetine on body weight, waist circumference, and body mass index in individuals who are overweight or have obesity: a meta-analysis of randomized controlled trials.International journal of obesity (2005) · 2025Pooled it
- Multi-ancestry genome-wide association analyses incorporating SNP-by-psychosocial interactions identify novel loci for serum lipids.Translational psychiatry · 2025Pooled it
- The association between metabolically healthy obesity and risk of depression: a systematic review and meta-analysis.International journal of obesity (2005) · 2025Pooled it
- Efficacy of ginsenoside Rg1 on rodent models of depression: A systematic review and meta-analysis.Psychopharmacology · 2025Pooled it
- Barriers and facilitators of physical activity for individuals with depression: a systematic review within the socio-ecological model framework.Frontiers in sports and active living · 2025Pooled it
- Safety, tolerability, and preliminary efficacy of seltorexant versus quetiapine extended release as adjunctive therapy in major depressive disorder: a randomized, flexible-dose, 6-month, parallel-group, exploratory study.The international journal of neuropsychopharmacology · 2026Trial
- Digital cognitive behavioural therapy for depression and obesity after laparoscopic sleeve gastrectomy: a study protocol.Journal of health, population, and nutrition · 2026Trial
- Psychiatric Safety of Tirzepatide in People With Obesity and No Known Major Psychopathology: A Post Hoc Analysis of SURMOUNT.Obesity (Silver Spring, Md.) · 2026Trial
- Obesity and Cardiovascular Disease: An Obesity Medicine Association (OMA) Clinical Practice Statement (CPS) 2026.Obesity pillars · 2026Review
- Nonlinear association between body roundness index and depressive symptoms in women of reproductive age: The mediating role of systemic inflammation.Brain, behavior, & immunity - health · 2026Article
- Plasma proteomic profile of inflammatory depressive symptoms.Brain, behavior, & immunity - health · 2026Article
- The mediating role of brain structural-functional connectivity coupling in linking paternal education to BMI and depressive scores in young adults.BMC psychiatry · 2026Article
- GLP-1 and dual GIP/GLP-1 receptor agonists' psychopharmacology and putative neuropsychiatric associated effects: a Bradford Hill-informed, systematic, evaluation.Current psychiatry reports · 2026Review
- Psychiatric and Psychosocial Outcomes of Bariatric Surgery in Adolescents and Adult Women: A Prospective Cohort Study.Journal of clinical medicine · 2026Article
- Association Between a Body Shape Index and Epilepsy Among US Adults: Potential Indirect Pathway Through Depressive Symptoms.Brain and behavior · 2026Article
- Food addiction as a mediator in the association between depression and body mass index among young adults in South Korea: a cross-sectional study.Journal of Korean biological nursing science · 2026Article
- Metabolites stratify future major depressive disorder risk in obese population: a longitudinal machine learning analysis.Psychological medicine · 2026Article
494 more citing papers are in PubMed but not listed here.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Depression and obesity are common conditions with major public health implications that tend to co-occur within individuals. The relationship between these conditions is bidirectional: the presence of one increases the risk for developing the other. It has thus become crucial to gain a better understanding of the mechanisms responsible for the intertwined downward physiological spirals associated with both conditions. The present review focuses specifically on shared biological pathways that may mechanistically explain the depression-obesity link, including genetics, alterations in systems involved in homeostatic adjustments (HPA axis, immuno-inflammatory activation, neuroendocrine regulators of energy metabolism including leptin and insulin, and microbiome) and brain circuitries integrating homeostatic and mood regulatory responses. Furthermore, the review addresses interventional opportunities and questions to be answered by future research that will enable a comprehensive characterization and targeting of the biological links between depression and obesity.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.