Evidence map›Paper›PMID 29453401›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2018

Endothelial smoothened-dependent hedgehog signaling is not required for sonic hedgehog induced angiogenesis or ischemic tissue repair.

Rajesh Gupta, Alexander R Mackie, Sol Misener, Lijun Liu, Douglas W Losordo, Raj Kishore

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Review
  3. Review
  4. Review
  5. Article
  6. Review
  7. The Hedgehog Signaling Pathway in Ischemic Tissues.International journal of molecular sciences · 2019
    Review
  8. Review
  9. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rajesh GuptaDepartment of Medicine, College of Medicine and Life Sciences,, University of Toledo,, Toledo, OH, USA. rajesh.gupta@utoledo.edu.
Alexander R MackieFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.
Sol MisenerFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.
Lijun LiuDepartment of Medicine, College of Medicine and Life Sciences,, University of Toledo,, Toledo, OH, USA.
Douglas W LosordoFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.
Raj KishoreFeinberg Cardiovascular Research Institute, Northwestern University, Chicago, IL, USA.
Northwestern University · USUniversity of Toledo · US

Funding

Small and large animal surgery, physiology and histologyP01HL134608 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI Raj Kishore · 2017 to 2026
$21.0M
Small Animal Surgery and HistologyP01HL108795 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI LOSORDO, DOUGLAS W · 2011 to 2015
$10.7M
TNF mRNA stability and restenosisR01HL091983 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2009 to 2022
$5.3M
Therapeutic Angiogenesis in Vascular Medicine IVR01HL053354 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 1995 to 2015
$4.2M
Pluripotent cell-derived exosomes as mediators of myocardial regenerationR01HL126186 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2015 to 2018
$1.6M
Novel approaches to ischemic tissue repairR01HL095874 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI KISHORE, RAJ · 2009 to 2012
$1.5M
Effect of chronic alcohol on ischemic injury and endothelial cellsR01HL105597 · NHLBI · TEMPLE UNIV OF THE COMMONWEALTH · PI KISHORE, RAJ · 2011 to 2014
$1.5M
THERAPEUTIC ANGIOGENESIS IN VASCULAR MEDICINE IIR37HL053354 · NHLBI · CARITAS ST. ELIZABETH'S MEDICAL CENTER · PI ISNER, JEFFREY · 2000 to 2001
$726k
The Role of Hedgehog Interacting Protein in Sonic Hedgehog Mediated AgiogenesisF32HL099283 · NHLBI · NORTHWESTERN UNIVERSITY AT CHICAGO · PI GUPTA, RAJESH · 2010 to 2012
$140k
NHLBI NIH HHS F32 HL099283NHLBI NIH HHS P01 HL108795NHLBI NIH HHS P01 HL134608NHLBI NIH HHS R01 HL053354NHLBI NIH HHS R01 HL091983NHLBI NIH HHS R01 HL095874NHLBI NIH HHS R01 HL105597NHLBI NIH HHS R01 HL126186NHLBI NIH HHS R37 HL053354
6 · The paper itself

Abstract

Sonic Hedgehog (Shh) signaling induces neovascularization and angiogenesis. It is not known whether the hedgehog signaling pathway in endothelial cells is essential to angiogenesis. Smoothened (Smo) transduces hedgehog signaling across the cell membrane. This study assessed whether endothelial Smoothened-dependent Shh signaling is required for Shh-mediated angiogenesis and ischemic tissue repair. Endothelial-specific smoothened knockout mice, eSmo

Indexed as

Neovascularization, PhysiologicAnimalsCells, CulturedEndothelial CellsFibroblastsHedgehog ProteinsHindlimbIschemiaMaleMiceSignal TransductionSmoothened ReceptorHedgehog ProteinsShh protein, mouseSmoothened ReceptorSmo protein, mouse

Identifiers

PMID29453401
PMCPMC5976512
OpenAlexW2791829456

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.