ArticleScientific reports2018
A novel flatworm-specific gene implicated in reproduction in Macrostomum lignano.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 29 citations in OpenAlex.
- Article
- Knockdown-Induced Fasting Phenotypes in Flatworms: Insights into Underlying Mechanisms of Feeding Behavior.International journal of molecular sciences · 2025Article
- One probe fits all: a highly customizable modular RNA in situ hybridization platform expanding the application of SABER DNA probes.Development (Cambridge, England) · 2025Article
- Optimized protocols for RNA interference in Macrostomum lignano.G3 (Bethesda, Md.) · 2024Article
- Genome assemblies of the simultaneously hermaphroditic flatworms Macrostomum cliftonense and Macrostomum hystrix.G3 (Bethesda, Md.) · 2023Article
- Mating strategy predicts gene presence/absence patterns in a genus of simultaneously hermaphroditic flatworms.Evolution; international journal of organic evolution · 2022Article
- Article
- Random Integration Transgenesis in a Free-Living Regenerative Flatworm Macrostomum lignano.Methods in molecular biology (Clifton, N.J.) · 2022Article
- Faster Rates of Molecular Sequence Evolution in Reproduction-Related Genes and in Species with Hypodermic Sperm Morphologies.Molecular biology and evolution · 2021Article
- TIM29 is required for enhanced stem cell activity during regeneration in the flatworm Macrostomum lignano.Scientific reports · 2021Article
- RNA-Seq of three free-living flatworm species suggests rapid evolution of reproduction-related genes.BMC genomics · 2020Article
- The free-living flatwormEvoDevo · 2020Review
- Seminal fluid-mediated fitness effects in the simultaneously hermaphroditic flatwormEcology and evolution · 2019Article
- Influence of temperature on development, reproduction and regeneration in the flatworm model organism,Zoological letters · 2019Article
- The regenerative flatworm Macrostomum lignano, a model organism with high experimental potential.The International journal of developmental biology · 2018Review
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Free-living flatworms, such as the planarian Schmidtea mediterranea, are extensively used as model organisms to study stem cells and regeneration. The majority of flatworm studies so far focused on broadly conserved genes. However, investigating what makes these animals different is equally informative for understanding its biology and might have biomedical value. We re-analyzed the neoblast and germline transcriptional signatures of the flatworm M. lignano using an improved transcriptome assembly and show that germline-enriched genes have a high fraction of flatworm-specific genes. We further identified the Mlig-sperm1 gene as a member of a novel gene family conserved only in free-living flatworms and essential for producing healthy spermatozoa. In addition, we established a whole-animal electron microscopy atlas (nanotomy) to visualize the ultrastructure of the testes in wild type worms, but also as a reference platform for different ultrastructural studies in M. lignano. This work demonstrates that investigation of flatworm-specific genes is crucial for understanding flatworm biology and establishes a basis for such future research in M. lignano.
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