ArticleScientific reports2018
ABCG2 contributes to the development of gout and hyperuricemia in a genome-wide association study.
Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers, 3 of them syntheses that pooled it.
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Who cites it
44 citing papers in PubMed, 3 syntheses or guidelines pooled it, 111 citations in OpenAlex.
- Discovery and prioritization of genetic determinants of kidney function in 297,355 individuals from Taiwan and Japan.Nature communications · 2024Pooled it
- The association between genetic polymorphisms in ABCG2 and SLC2A9 and urate: an updated systematic review and meta-analysis.BMC medical genetics · 2020Pooled it
- Integrative Genome-Wide Association Studies of eQTL and GWAS Data for Gout Disease Susceptibility.Scientific reports · 2019Pooled it
- Association of the ABCG2 Q141K variant with gout in Kinh Vietnamese: a cross-sectional study.Clinical rheumatology · 2025Article
- Integrating natural products with modern medicine in the treatment of gouty arthritis: a review.Inflammopharmacology · 2025Review
- Revisiting the Role of the Leucine Plug/Valve in the Human ABCG2 Multidrug Transporter.International journal of molecular sciences · 2025Article
- Editorial: Community series in advances in pathogenesis and therapies of gout, volume II.Frontiers in immunology · 2025Article
- Advances in drug delivery systems for the management of gout and hyperuricemia.Frontiers in pharmacology · 2025Review
- FABIO: TWAS fine-mapping to prioritize causal genes for binary traits.PLoS genetics · 2024Article
- Hyperuricemia and its related diseases: mechanisms and advances in therapy.Signal transduction and targeted therapy · 2024Review
- The pathogenesis of gout: molecular insights from genetic, epigenomic and transcriptomic studies.Nature reviews. Rheumatology · 2024Review
- Whole-genome sequencing reveals rare variants associated with gout in Taiwanese males.Frontiers in genetics · 2024Article
- Mendelian randomization analysis identified potential genes pleiotropically associated with gout.Frontiers in genetics · 2024Article
- Polymorphism rs3733591 of theFrontiers in genetics · 2024Article
- Association Between Family History in Patients with Primary Gout and Left Ventricular Diastolic Function: A Cross-Sectional Study.International journal of general medicine · 2024Article
- Deciphering genetic causes for sex differences in human health through drug metabolism and transporter genes.Nature communications · 2023Article
- Enrichment analysis and chromosomal distribution of gout susceptible loci identified by genome-wide association studies.EXCLI journal · 2023Article
- TheFrontiers in endocrinology · 2023Article
- Polygenic risk score trend and new variants on chromosome 1 are associated with male gout in genome-wide association study.Arthritis research & therapy · 2022Article
- Susceptibility genes of hyperuricemia and gout.Hereditas · 2022Review
Corrections and comments
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Authors and funding
8 authors at 6 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Although many genome-wide association studies (GWASs) of hyperuricemia or gout have been reported, the related genetic factors and the mechanisms from hyperuricemia to gouty attack remain unclear. This study aimed to identify genetic factors and pathogenesis of gout from hyperuricemia by genome-wide association study (GWAS). 747 gout patients, 747 hyperuricemia and 2071 age-matched controls were recruited and analyzed with Affymetrix 650 K chip to find the related genetic variants. The functions of the related genes were investigated in an endothelial cell (EC) with urate crystal stimulation. The GWAS results showed 36 SNPs to be strongly associated with gout compared to controls (all p-values < 10
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