Evidence map›Paper›PMID 29453343›Full record

ArticleScientific reports2018

Effect of chronic exercise on fluoride metabolism in fluorosis-susceptible mice exposed to high fluoride.

Sandra L Amaral, Liane B Azevedo, Marilia A R Buzalaf, Mayara F Fabricio, Mileni S Fernandes, Ruth A Valentine, Anne Maguire, Fatemeh V Zohoori

Open access · goldAbstract read
In one paragraph

Article in Scientific reports, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.7field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 26 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
  6. Article
  7. Fluoride exposure and duration and quality of sleep in a Canadian population-based sample.Environmental health : a global access science source · 2021
    Article
  8. Article
  9. Article
  10. Fluoride Exposure Induces Inhibition of Sodium-and Potassium-Activated Adenosine Triphosphatase (NaInternational journal of environmental research and public health · 2019
    Review
  11. Article
  12. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Sandra L AmaralDepartment of Physical Education, Science Faculty, São Paulo State University, Bauru, São Paulo, 17033-360, Brazil.
Liane B AzevedoSchool of Health and Social Care, Teesside University, Middlesbrough, TS1 3BA, UK.ORCID 0000-0001-9966-9414
Marilia A R BuzalafBauru School of Dentistry, University of São Paulo, Bauru, SP, 17012-901, Brazil.
Mayara F FabricioDepartment of Physical Education, Science Faculty, São Paulo State University, Bauru, São Paulo, 17033-360, Brazil.
Mileni S FernandesBauru School of Dentistry, University of São Paulo, Bauru, SP, 17012-901, Brazil.
Ruth A ValentineCentre for Oral Health Research, School of Dental Sciences, Newcastle University, NE2 4BW, Newcastle-upon-Tyne, NE2 4BW, UK.
Anne MaguireCentre for Oral Health Research, School of Dental Sciences, Newcastle University, NE2 4BW, Newcastle-upon-Tyne, NE2 4BW, UK.
Fatemeh V ZohooriSchool of Health and Social Care, Teesside University, Middlesbrough, TS1 3BA, UK. v.zohoori@tees.ac.uk.
Newcastle University · GBTeesside University · GBUniversidade de São Paulo · BRUniversidade Estadual Paulista (Unesp) · BR

Funding

Medical Research Council MR/K02325X/1
6 · The paper itself

Abstract

The present study investigated the effect of chronic exercise on fluoride (F) metabolism in fluorosis-susceptible mice exposed to high-F and explored the relationship between F concentrations in bone and plasma. Thirty male mice were randomised into three groups: Group I (No-F, No-Exercise), Group II (50 ppmF, No-Exercise), Group III (50 ppmF, Exercise). Body weight and physical performance of all mice were measured at baseline and end of experiment. F concentrations of plasma and bone were measured at the end of experiment. Mean plasma F concentration was significantly higher (p < 0.001) in Groups II and III compared with Group I. Mean bone F concentration was also significantly higher (p < 0.01) in Groups II and III compared with Group I. There was a significant correlation (p = 0.01, r = 0.54) between F concentration of plasma and bone. Mean body weight of Group I mice was significantly higher than Group II (p < 0.001) and Group III (p = 0.001) mice at the end of the experiment. This study, which provides the first data on the effect of chronic exercise on F metabolism in fluorosis-susceptible mice, suggests no effect of chronic exercise on F in plasma and bone. However, exposure to high-F resulted in lower body weight and exercise capacity in mice.

Indexed as

AnimalsBody WeightBone and BonesFluoridesFluorosis, DentalMaleMicePhysical Conditioning, AnimalPhysical Functional PerformanceFluorides

Identifiers

PMID29453343
PMCPMC5816643
OpenAlexW2787901372

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.