Evidence map›Paper›PMID 29453320›Full record

ArticleMolecular cancer research : MCR2018

Methylation of the HOXA10 Promoter Directs miR-196b-5p-Dependent Cell Proliferation and Invasion of Gastric Cancer Cells.

Linlin Shao, Zheng Chen, Dunfa Peng, Mohammed Soutto, Shoumin Zhu, Andreia Bates, Shutian Zhang, Wael El-Rifai

Open access · greenAbstract read
In one paragraph

Article in Molecular cancer research : MCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed, 1 pooled it
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 1 synthesis or guideline pooled it, 65 citations in OpenAlex.

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  12. Translational cancer research · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Linlin Shao *Department of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China.
Zheng Chen *Department of Surgery, University of Miami, Miller School of Medicine, Miami, Florida.
Dunfa PengDepartment of Surgery, University of Miami, Miller School of Medicine, Miami, Florida.
Mohammed SouttoDepartment of Surgery, University of Miami, Miller School of Medicine, Miami, Florida.
Shoumin ZhuDepartment of Surgery, University of Miami, Miller School of Medicine, Miami, Florida.
Andreia BatesDepartment of Surgery, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Shutian ZhangDepartment of Gastroenterology, Beijing Friendship Hospital, Capital Medical University, Beijing, China. wxe45@miami.edu zhangshutian@ccmu.edu.cn.
Wael El-Rifai *Department of Surgery, University of Miami, Miller School of Medicine, Miami, Florida. wxe45@miami.edu zhangshutian@ccmu.edu.cn.
Beijing Friendship Hospital · CN

Funding

Targets of Gene Overexpression at 17q in Gastric Tumorigenesis: Darpp32R01CA093999 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI EL-RIFAI, WAEL · 2002 to 2017
$4.5M
The Role of miRNA Network in Gastric CancerR01CA177372 · NCI · VANDERBILT UNIVERSITY MEDICAL CENTER · PI EL-RIFAI, WAEL · 2013 to 2015
$446k
Molecular Pathobiology of Gastric CarcinogenesisI01BX001179 · VA · VETERANS HEALTH ADMINISTRATION · PI EL-RIFAI, WAEL · 2012 to 2024
–
BLRD Research Career Scientist Award ApplicationIK6BX003787 · VA · VETERANS HEALTH ADMINISTRATION · PI WAEL EL-RIFAI · 2017 to 2026
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BLRD VA I01 BX001179BLRD VA IK6 BX003787NCI NIH HHS R01 CA093999NCI NIH HHS R01 CA177372
6 · The paper itself

Abstract

The cross-talk between epigenetics and miRNA expression plays an important role in human tumorigenesis. Herein, the regulation and role of miR-196b-5p in gastric cancer was investigated. qRT-PCR demonstrated that miR-196b-5p is significantly overexpressed in human gastric cancer tissues (

Indexed as

DNA MethylationUp-RegulationAnimalsCell Line, TumorCell ProliferationDecitabineEpigenesis, GeneticGene Expression Regulation, NeoplasticHomeobox A10 ProteinsHomeodomain ProteinsHumansMiceMice, KnockoutMicroRNAsNeoplasm InvasivenessPrognosisDecitabineHomeobox A10 ProteinsHomeodomain ProteinsHOXA10 protein, humanMicroRNAsMIRN196 microRNA, humanTFF1 protein, humanTrefoil Factor-1

Identifiers

PMID29453320
PMCPMC5882501
OpenAlexW2787549557

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.