Evidence map›Paper›PMID 29453314›Full record

ArticleMolecular cancer research : MCR2018

AR Expression in Breast Cancer CTCs Associates with Bone Metastases.

Nicola Aceto, Aditya Bardia, Ben S Wittner, Maria C Donaldson, Ryan O'Keefe, Amanda Engstrom, Francesca Bersani, Yu Zheng, Valentine Comaills, Kira Niederhoffer and 11 more

Registry-linked trialOpen access · bronzeAbstract readComparative Study
In one paragraph

Article in Molecular cancer research : MCR, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05054010 (Identification and Characterization of Commercial RUO Antibodies for the Detection of Specific Breast Cancer Tumoral Markers Expressed in Potential Circulating Tumoral Cells), which is not on this map. Cited by 59 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
59citing papers in PubMed, 1 pooled it
8.8field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05054010 active not recruitingnot on this mapstarted 2021, after this paper: background citation

Identification and Characterization of Commercial RUO Antibodies for the Detection of Specific Breast Cancer Tumoral Markers Expressed in Potential Circulating Tumoral Cells (CTCs)

TypeobservationalSponsorTethis S.p.A.Ran2021 to 2026Enrolled84ConditionsBreast Neoplasms
3 · Its place in the literature

Who cites it

59 citing papers in PubMed, 1 synthesis or guideline pooled it, 96 citations in OpenAlex.

  1. Pooled it
  2. Trial
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Review
  10. Precision Oncology Framework Using Circulating Tumor Cells.International journal of molecular sciences · 2025
    Review
  11. Article
  12. Hormone Signaling in Breast Development and Cancer.Advances in experimental medicine and biology · 2025
    Review
  13. Review
  14. Article
  15. Review
  16. Article
  17. Review
  18. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 1 institution in 1 country.

Nicola AcetoMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Aditya BardiaMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Ben S WittnerMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Maria C DonaldsonMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Ryan O'KeefeMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Amanda EngstromMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Francesca BersaniMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Yu ZhengMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Valentine ComaillsMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Kira NiederhofferMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Huili ZhuMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Olivia MackenzieMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Toshi ShiodaMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Dennis SgroiMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Ravi KapurCenter for Bioengineering in Medicine, Harvard Medical School, Boston, Massachusetts.
David T TingMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Beverly MoyMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Sridhar RamaswamyMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts.
Mehmet TonerCenter for Bioengineering in Medicine, Harvard Medical School, Boston, Massachusetts.
Daniel A HaberMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. dhaber@mgh.harvard.edu maheswaran@helix.mgh.harvard.edu.
Shyamala MaheswaranMassachusetts General Hospital Cancer Center, Harvard Medical School, Boston, Massachusetts. dhaber@mgh.harvard.edu maheswaran@helix.mgh.harvard.edu.
Harvard University · US

Funding

Point-of care Microfluidics for Early Detection of CancerU01EB012493 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI HABER, DANIEL A., TONER, MEHMET · 2010 to 2018
$19.6M
Dana Farber/Harvard Cancer Consortium Career Development Program in Clinical OncologyK12CA087723 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI David Tsai Ting · 2002 to 2026
$17.9M
Modeling Metastasis and Acquired Drug Resistance Using Circulating Tumor CellsR01CA129933 · NCI · MASSACHUSETTS GENERAL HOSPITAL · PI Daniel A. Haber · 2008 to 2026
$7.5M
Point-of-Care Microfluidics in Lung CancerR01EB008047 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI TONER, MEHMET · 2007 to 2009
$3.4M
Howard Hughes Medical InstituteNCI NIH HHS K12 CA087723NCI NIH HHS R01 CA129933NIBIB NIH HHS R01 EB008047NIBIB NIH HHS U01 EB012493
6 · The paper itself

Abstract

Molecular drivers underlying bone metastases in human cancer are not well understood, in part due to constraints in bone tissue sampling. Here, RNA sequencing was performed of circulating tumor cells (CTC) isolated from blood samples of women with metastatic estrogen receptor (ER)

Indexed as

Abdominal NeoplasmsAlternative SplicingAnimalsAntineoplastic Agents, HormonalBiomarkers, TumorBone NeoplasmsBreast NeoplasmsDrug Resistance, NeoplasmFemaleHumansMiceNeoplastic Cells, CirculatingReceptors, AndrogenSequence Analysis, RNASingle-Cell AnalysisAntineoplastic Agents, HormonalAR protein, humanBiomarkers, TumorReceptors, Androgen

Identifiers

PMID29453314
PMCPMC5882540
OpenAlexW2788743957

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.