ArticleJournal of the American Heart Association2018
Acute Pressor Response to Psychosocial Stress Is Dependent on Endothelium-Derived Endothelin-1.
Article in Journal of the American Heart Association, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 27 citations in OpenAlex.
- Progressive exercise training improves cardiovascular psychophysiological outcomes in young adult women with a history of adverse childhood experiences.Journal of applied physiology (Bethesda, Md. : 1985) · 2023Trial
- Endothelin receptor blockade blunts the pressor response to acute stress in men and women with obesity.Journal of applied physiology (Bethesda, Md. : 1985) · 2022Trial
- Early life stress blunts time-of-day-specific autonomic function in adult male mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2026Article
- Endothelin receptor antagonism in sickle cell disease: Is the time now?Canadian journal of physiology and pharmacology · 2026Review
- SCD and asthma comorbidity: the potential role of adverse childhood experiences.Journal of sickle cell disease · 2025Article
- Pathophysiological dynamics of acute myocardial infarction rats under chronic psychological stress at different time points.Scientific reports · 2024Article
- Association of early life adversity with cardiovascular disease and its potential mechanisms: a narrative review.Frontiers in public health · 2024Review
- Endothelin Modulates Rhythm Disturbances and Autonomic Responses to Acute Emotional Stress in Rats.Biology · 2023Article
- The sex-dependent response to psychosocial stress and ischaemic heart disease.Frontiers in cardiovascular medicine · 2023Review
- Emerging Therapeutic Targets for Portal Hypertension.Current hepatology reports · 2023Review
- Endothelin System and Ischemia-Induced Ventricular Tachyarrhythmias.Life (Basel, Switzerland) · 2022Review
- Impact of Acute and Chronic Psychosocial Stress on Vascular Inflammation.Antioxidants & redox signaling · 2021Article
- Liver circadian clock disruption alters perivascular adipose tissue gene expression and aortic function in mice.American journal of physiology. Regulatory, integrative and comparative physiology · 2021Article
- PTSD as an Endothelial Disease: Insights From COVID-19.Frontiers in cellular neuroscience · 2021Review
- Endothelin-1 in the pathophysiology of obesity and insulin resistance.Obesity reviews : an official journal of the International Association for the Study of Obesity · 2020Review
- Greater Daily Psychosocial Stress Exposure is Associated With Increased Norepinephrine-Induced Vasoconstriction in Young Adults.Journal of the American Heart Association · 2020Article
- Elevated plasma endothelin-1 is associated with reduced weight loss post vertical sleeve gastrectomy.Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery · 2019Article
- Involvement of Endothelin 1 in Remote Preconditioning-Induced Cardioprotection through connexin 43 and Akt/GSK-3β Signaling Pathway.Scientific reports · 2018Article
Corrections and comments
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Authors and funding
10 authors at 5 institutions in 2 countries.
Funding
Abstract
backgroundAcute psychosocial stress provokes increases in circulating endothelin-1 (ET-1) levels in humans and animal models. However, key questions about the physiological function and cellular source of stress-induced ET-1 remain unanswered. We hypothesized that endothelium-derived ET-1 contributes to the acute pressor response to stress via activation of the endothelin A receptor. METHODS AND
resultsAdult male vascular endothelium-specific ET-1 knockout mice and control mice that were homozygous for the floxed allele were exposed to acute psychosocial stress in the form of cage switch stress (CSS), with blood pressure measured by telemetry. An acute pressor response was elicited by CSS in both genotypes; however, this response was significantly blunted in vascular endothelium-specific ET-1 knockout mice compared with control mice that were homozygous for the floxed allele. In mice pretreated for 3 days with the endothelin A antagonist, ABT-627, or the dual endothelin A/B receptor antagonist, A-182086, the pressor response to CSS was similar between genotypes. CSS significantly increased plasma ET-1 levels in control mice that were homozygous for the floxed allele. CSS failed to elicit an increase in plasma ET-1 in vascular endothelium-specific ET-1 knockout mice. Telemetry frequency domain analyses suggested similar autonomic responses to stress between genotypes, and isolated resistance arteries demonstrated similar sensitivity to α
conclusionsThese findings specify that acute stress-induced activation of endothelium-derived ET-1 and subsequent endothelin A receptor activation is a novel mediator of the blood pressure response to acute psychosocial stress.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.