Evidence map›Paper›PMID 29453284›Full record

ArticleThe Journal of biological chemistry2018

Structural and compositional diversity of fibrillin microfibrils in human tissues.

Alexander Eckersley, Kieran T Mellody, Suzanne Pilkington, Christopher E M Griffiths, Rachel E B Watson, Ronan O'Cualain, Clair Baldock, David Knight, Michael J Sherratt

Open access · hybridAbstract read
In one paragraph

Article in The Journal of biological chemistry, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.

0numbers the graph read from it
0cells of the map it votes in
36citing papers in PubMed
7.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

36 citing papers in PubMed, 69 citations in OpenAlex.

  1. Article
  2. Proteomic profiling of metabolizing enzymes and transporters in 2 layers of Caucasian human skin.Drug metabolism and disposition: the biological fate of chemicals · 2026
    Article
  3. Article
  4. Article
  5. X-Ray Exposure Induces Structural Changes in Human Breast Proteins.International journal of molecular sciences · 2025
    Article
  6. Article
  7. Review
  8. Review
  9. Mechanisms of assembly and remodelling of the extracellular matrix.Nature reviews. Molecular cell biology · 2024
    Review
  10. Article
  11. Review
  12. Article
  13. Article
  14. Article
  15. Review
  16. Review
  17. Article
  18. Review
  19. Article
  20. Association between single nucleotide polymorphisms of tropoelastin gene and aortic dissection.Zhong nan da xue xue bao. Yi xue ban = Journal of Central South University. Medical sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 1 country.

Alexander EckersleyFrom the Division of Cell Matrix Biology and Regenerative Medicine.
Kieran T MellodyFrom the Division of Cell Matrix Biology and Regenerative Medicine.
Suzanne Pilkingtonthe Division of Musculoskeletal and Dermatological Sciences.
Christopher E M Griffithsthe Division of Musculoskeletal and Dermatological Sciences.
Rachel E B Watsonthe Division of Musculoskeletal and Dermatological Sciences.
Ronan O'Cualainthe School of Biological Sciences, and.
Clair BaldockFrom the Division of Cell Matrix Biology and Regenerative Medicine.
David Knightthe School of Biological Sciences, and.
Michael J Sherrattthe School of Biological Sciences, and michael.sherratt@manchester.ac.uk.
Manchester Academic Health Science Centre · GBNIHR Manchester Biomedical Research Centre · GBWellcome Centre for Cell-Matrix Research · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N015398/1Medical Research Council MR/L016540/1Wellcome TrustWellcome Trust 088785/Z/09/Z
6 · The paper itself

Abstract

Elastic fibers comprising fibrillin microfibrils and elastin are present in many tissues, including the skin, lungs, and arteries, where they confer elasticity and resilience. Although fibrillin microfibrils play distinct and tissue-specific functional roles, it is unclear whether their ultrastructure and composition differ between elastin-rich (skin) and elastin-poor (ciliary body and zonule) organs or after

Indexed as

AdipokinesAgedCells, CulturedCollagen Type VIEyeFemaleFibrillin-1HumansMaleMicrofibrilsMicroscopy, Atomic ForceProtein ConformationSkinAdipokinesCollagen Type VIFBN1 protein, humanFibrillin-1atomic force microscopy (AFM)collagen VIextracellular matrixeyefibrillin microfibrilfibroblastprotein structureproteomicsskin

Identifiers

PMID29453284
PMCPMC5892578
OpenAlexW2787170837

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.