Evidence map›Paper›PMID 29453276›Full record

ArticleProceedings of the National Academy of Sciences of the United States of America2018

Entropy drives selective fluorine recognition in the fluoroacetyl-CoA thioesterase from

Amy M Weeks, Ningkun Wang, Jeffrey G Pelton, Michelle C Y Chang

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Proceedings of the National Academy of Sciences of the United States of America, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.6field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 13 citations in OpenAlex.

  1. Complete genome sequence of fluoroacetate-degradingMicrobiology resource announcements · 2025
    Article
  2. Article
  3. Enzymatic synthesis of fluorinated compounds.Applied microbiology and biotechnology · 2021
    Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Amy M WeeksDepartment of Chemistry, University of California, Berkeley, CA 94720-1460.
Ningkun WangDepartment of Chemistry, University of California, Berkeley, CA 94720-1460.
Jeffrey G PeltonQB3 Institute, University of California, Berkeley, CA 94720-1460.
Michelle C Y ChangDepartment of Chemistry, University of California, Berkeley, CA 94720-1460; mcchang@berkeley.edu.
University of California, Berkeley · US

Funding

Univ of Calif Berkeley Chemistry-Biology Interface ProgramT32GM066698 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, CHRISTOPHER J., FRANCIS, MATTHEW B · 2004 to 2023
$7.5M
Proposal for Central California 900 MHZ NMR SpectrometerP41GM068933 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI WEMMER, DAVID E · 2003 to 2007
$5.9M
Synthetic Biology Approaches to New Fluorinated PharmaceuticalsR01GM123181 · NIGMS · UNIVERSITY OF CALIFORNIA BERKELEY · PI CHANG, MICHELLE C · 2017 to 2020
$1.3M
NIGMS NIH HHS P41 GM068933NIGMS NIH HHS R01 GM123181NIGMS NIH HHS T32 GM066698
6 · The paper itself

Abstract

Fluorinated small molecules play an important role in the design of bioactive compounds for a broad range of applications. As such, there is strong interest in developing a deeper understanding of how fluorine affects the interaction of these ligands with their targets. Given the small number of fluorinated metabolites identified to date, insights into fluorine recognition have been provided almost entirely by synthetic systems. The fluoroacetyl-CoA thioesterase (FlK) from

Indexed as

Acetyl Coenzyme ABacterial ProteinsCatalytic DomainEntropyFluorineNuclear Magnetic Resonance, BiomolecularPhenylalanineProtein BindingStreptomycesSubstrate SpecificityAcetyl Coenzyme ABacterial ProteinsFluorinefluoroacetyl-coenzyme APhenylalanineenzyme selectivityfluorinemetabolismmolecular recognitionorganofluorine

Identifiers

PMID29453276
PMCPMC5877923
OpenAlexW2788343488

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.