ArticleMolecular pharmacology2018
Retinal-chitosan Conjugates Effectively Deliver Active Chromophores to Retinal Photoreceptor Cells in Blind Mice and Dogs.
Open access · bronzeAbstract read
In one paragraph
Article in Molecular pharmacology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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0cells of the map it votes in
12citing papers in PubMed
1.0field-weighted citation impact, top 25% of its field
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
12 citing papers in PubMed, 21 citations in OpenAlex.
- Chromophore-loaded CRALBP mutant proteins restore rod function in chromophore-deficient mice.Molecular therapy. Advances · 2026Article
- Retinoid therapy restores eye-specific cortical responses in adult mice with retinal degeneration.Current biology : CB · 2022Article
- Neuroinflammation as a Therapeutic Target in Retinitis Pigmentosa and Quercetin as Its Potential Modulator.Pharmaceutics · 2021Review
- Theoretical Study of the Photoisomerization Mechanism of All-The journal of physical chemistry. A · 2021Article
- Redox-Responsive Hyaluronic Acid-Based Nanogels for the Topical Delivery of the Visual Chromophore to Retinal Photoreceptors.ACS omega · 2021Article
- Clinical Perspective: Treating RPE65-Associated Retinal Dystrophy.Molecular therapy : the journal of the American Society of Gene Therapy · 2021Review
- Article
- Long-Term Structural Outcomes of Late-Stage RPE65 Gene Therapy.Molecular therapy : the journal of the American Society of Gene Therapy · 2020Article
- The Retinoid and Non-Retinoid Ligands of the Rod Visual G Protein-Coupled Receptor.International journal of molecular sciences · 2019Review
- Z-isomerization of retinoids through combination of monochromatic photoisomerization and metal catalysis.Organic & biomolecular chemistry · 2019Article
- Catalytic synthesis of 9-cis-retinoids: mechanistic insights.Dalton transactions (Cambridge, England : 2003) · 2019Article
- Flavonoids enhance rod opsin stability, folding, and self-association by directly binding to ligand-free opsin and modulating its conformation.The Journal of biological chemistry · 2019Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Songqi GaoDepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (S.G., S.K., J.Z., B.J., K.P.) and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan (J.Q., S.M.P.-J.).
Shirin KahremanyDepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (S.G., S.K., J.Z., B.J., K.P.) and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan (J.Q., S.M.P.-J.).
Jianye ZhangDepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (S.G., S.K., J.Z., B.J., K.P.) and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan (J.Q., S.M.P.-J.).
Beata JastrzebskaDepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (S.G., S.K., J.Z., B.J., K.P.) and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan (J.Q., S.M.P.-J.).
Janice QuerubinDepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (S.G., S.K., J.Z., B.J., K.P.) and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan (J.Q., S.M.P.-J.).
Simon M Petersen-JonesDepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (S.G., S.K., J.Z., B.J., K.P.) and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan (J.Q., S.M.P.-J.).
Krzysztof PalczewskiDepartment of Pharmacology and Cleveland Center for Membrane and Structural Biology, School of Medicine, Case Western Reserve University, Cleveland, Ohio (S.G., S.K., J.Z., B.J., K.P.) and Department of Small Animal Clinical Sciences, College of Veterinary Medicine, Michigan State University, East Lansing, Michigan (J.Q., S.M.P.-J.) kxp65@case.edu.
Case Western Reserve University · USMichigan State University · US
Funding
TISSUE CULTURE AND HYBRIDOMA MODULEP30EY011373 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI Irina A Pikuleva · 1997 to 2026
$17.7MSTRUCTURAL STUDIES OF ARRESTINSR01EY009339 · NEI · UNIVERSITY OF WASHINGTON · PI KISER, PHILIP DAVID, PALCZEWSKI, KRZYSZTOF · 1992 to 2025
$16.0MNovel therapies to inhibit Diabetic RetinopathyR24EY024864 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI KERN, TIMOTHY S · 2015 to 2019
$8.1MUse of systems pharmacology to prevent rod and cone photoreceptor degenerationR24EY027283 · NEI · UNIVERSITY OF CALIFORNIA-IRVINE · PI PALCZEWSKI, KRZYSZTOF · 2017 to 2021
$7.9MRESOURCE/SERVICE CORE C - MOLECULAR INFORMATICS MODULEP30EY025585 · NEI · CLEVELAND CLINIC LERNER COM-CWRU · PI Brian D Perkins · 2016 to 2026
$7.7MCarotinoids in VisionR01EY020551 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI VON LINTIG, JOHANNES FRIEDRICH · 2011 to 2024
$4.8MNon-hydrolysable analogs of retinal chromophore; potential new therapeutics to prevent retinal degenerationR01EY025214 · NEI · CASE WESTERN RESERVE UNIVERSITY · PI JASTRZEBSKA, BEATA · 2016 to 2020
$1.8MNEI NIH HHS P30 EY011373NEI NIH HHS P30 EY025585NEI NIH HHS R01 EY009339NEI NIH HHS R01 EY020551NEI NIH HHS R01 EY025214NEI NIH HHS R24 EY024864NEI NIH HHS R24 EY027283
Abstract
The retinoid (visual) cycle consists of a series of biochemical reactions needed to regenerate the visual chromophore 11-
Indexed as
AcyltransferasesAdministration, OralAnimalsBlindnessChitosanCone OpsinsDisease Models, AnimalDiterpenesDogsDose-Response Relationship, DrugElectroretinographyFemaleMaleMiceMice, Inbred C57BLMice, Knockout9-cis-retinalAcyltransferasesChitosanCone OpsinsDiterpeneslecithin-retinol acyltransferaseOpsinsRetinaldehydeRod Opsins
Identifiers
What OpenQuestion holds
Textmetadata
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.