Evidence map›Paper›PMID 29453249›Full record

ArticleBlood advances2018

Hhex induces promyelocyte self-renewal and cooperates with growth factor independence to cause myeloid leukemia in mice.

Jacob T Jackson, Ashley P Ng, Benjamin J Shields, Sue Haupt, Ygal Haupt, Matthew P McCormack

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Blood advances, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.8field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 9 citations in OpenAlex.

  1. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 1 country.

Jacob T JacksonAustralian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-6396-2739
Ashley P NgWalter and Eliza Hall Institute of Medical Research, Parkville, VIC, Australia.ORCID 0000-0001-9690-0879
Benjamin J ShieldsAustralian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia.ORCID 0000-0002-5317-6742
Sue HauptTumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID 0000-0003-2484-1712
Ygal HauptTumour Suppression Laboratory, Peter MacCallum Cancer Centre, Melbourne, VIC, Australia.ORCID 0000-0001-5925-0096
Matthew P McCormackAustralian Centre for Blood Diseases, Monash University, Melbourne, VIC, Australia.ORCID 0000-0003-1536-5611
Australian Centre for HIV and Hepatitis Virology Research · AUPeter MacCallum Cancer Centre · AUThe University of Melbourne · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The hematopoietically expressed homeobox (Hhex) transcription factor is overexpressed in human myeloid leukemias. Conditional knockout models of murine acute myeloid leukemia indicate that

Indexed as

Cell Self RenewalIntercellular Signaling Peptides and ProteinsAnimalsCell Culture TechniquesCell DifferentiationCell NucleusCyclin-Dependent Kinase Inhibitor p16Gene Expression Regulation, LeukemicGranulocyte Precursor CellsHomeodomain ProteinsLeukemia, MyeloidMiceTranscription FactorsCyclin-Dependent Kinase Inhibitor p16Hhex protein, mouseHomeodomain ProteinsIntercellular Signaling Peptides and ProteinsTranscription Factors

Identifiers

PMID29453249
PMCPMC5858476
OpenAlexW2792603131

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.