Evidence map›Paper›PMID 29453246›Full record

ArticleCirculation. Genomic and precision medicine2018

Yield of the

Jamie D Kapplinger, Krishna N Pundi, Nicholas B Larson, Thomas E Callis, David J Tester, Hennie Bikker, Arthur A M Wilde, Michael J Ackerman

Open access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Circulation. Genomic and precision medicine, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.

0numbers the graph read from it
0cells of the map it votes in
25citing papers in PubMed
4.3field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

25 citing papers in PubMed, 47 citations in OpenAlex.

  1. Review
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Review
  8. Review
  9. Article
  10. RYR2-ryanodinopathies: from calcium overload to calcium deficiency.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2023
    Article
  11. Review
  12. European Heart Rhythm Association (EHRA)/Heart Rhythm Society (HRS)/Asia Pacific Heart Rhythm Society (APHRS)/Latin American Heart Rhythm Society (LAHRS) Expert Consensus Statement on the state of genetic testing for cardiac diseases.Europace : European pacing, arrhythmias, and cardiac electrophysiology : journal of the working groups on cardiac pacing, arrhythmias, and cardiac cellular electrophysiology of the European Society of Cardiology · 2022
    Article
  13. Article
  14. Article
  15. Catecholaminergic Polymorphic Ventricular Tachycardia.Arrhythmia & electrophysiology review · 2022
    Review
  16. Article
  17. Review
  18. Article
  19. Article
  20. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 1 country.

Jamie D KapplingerFrom the Mayo Clinic School of Medicine (J.D.K., M.J.A.), Medical Scientist Training Program (J.D.K., M.J.A.), Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.), Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (N.B.L.), Division of Heart Rhythm Services, Department of Cardiovascular Diseases (D.J.T., M.J.A.), and Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN; Department of Medicine, Stanford University, Stanford, CA (K.N.P.); Transgenomic Inc, New Haven, CT (T.E.C.); and Department of Clinical Genetics (H.B.) and Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W.), Academic Medical Center, University of Amsterdam, The Netherlands.
Krishna N PundiFrom the Mayo Clinic School of Medicine (J.D.K., M.J.A.), Medical Scientist Training Program (J.D.K., M.J.A.), Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.), Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (N.B.L.), Division of Heart Rhythm Services, Department of Cardiovascular Diseases (D.J.T., M.J.A.), and Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN; Department of Medicine, Stanford University, Stanford, CA (K.N.P.); Transgenomic Inc, New Haven, CT (T.E.C.); and Department of Clinical Genetics (H.B.) and Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W.), Academic Medical Center, University of Amsterdam, The Netherlands.
Nicholas B LarsonFrom the Mayo Clinic School of Medicine (J.D.K., M.J.A.), Medical Scientist Training Program (J.D.K., M.J.A.), Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.), Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (N.B.L.), Division of Heart Rhythm Services, Department of Cardiovascular Diseases (D.J.T., M.J.A.), and Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN; Department of Medicine, Stanford University, Stanford, CA (K.N.P.); Transgenomic Inc, New Haven, CT (T.E.C.); and Department of Clinical Genetics (H.B.) and Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W.), Academic Medical Center, University of Amsterdam, The Netherlands.
Thomas E CallisFrom the Mayo Clinic School of Medicine (J.D.K., M.J.A.), Medical Scientist Training Program (J.D.K., M.J.A.), Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.), Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (N.B.L.), Division of Heart Rhythm Services, Department of Cardiovascular Diseases (D.J.T., M.J.A.), and Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN; Department of Medicine, Stanford University, Stanford, CA (K.N.P.); Transgenomic Inc, New Haven, CT (T.E.C.); and Department of Clinical Genetics (H.B.) and Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W.), Academic Medical Center, University of Amsterdam, The Netherlands.
David J TesterFrom the Mayo Clinic School of Medicine (J.D.K., M.J.A.), Medical Scientist Training Program (J.D.K., M.J.A.), Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.), Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (N.B.L.), Division of Heart Rhythm Services, Department of Cardiovascular Diseases (D.J.T., M.J.A.), and Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN; Department of Medicine, Stanford University, Stanford, CA (K.N.P.); Transgenomic Inc, New Haven, CT (T.E.C.); and Department of Clinical Genetics (H.B.) and Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W.), Academic Medical Center, University of Amsterdam, The Netherlands.
Hennie BikkerFrom the Mayo Clinic School of Medicine (J.D.K., M.J.A.), Medical Scientist Training Program (J.D.K., M.J.A.), Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.), Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (N.B.L.), Division of Heart Rhythm Services, Department of Cardiovascular Diseases (D.J.T., M.J.A.), and Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN; Department of Medicine, Stanford University, Stanford, CA (K.N.P.); Transgenomic Inc, New Haven, CT (T.E.C.); and Department of Clinical Genetics (H.B.) and Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W.), Academic Medical Center, University of Amsterdam, The Netherlands.
Arthur A M WildeFrom the Mayo Clinic School of Medicine (J.D.K., M.J.A.), Medical Scientist Training Program (J.D.K., M.J.A.), Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.), Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (N.B.L.), Division of Heart Rhythm Services, Department of Cardiovascular Diseases (D.J.T., M.J.A.), and Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN; Department of Medicine, Stanford University, Stanford, CA (K.N.P.); Transgenomic Inc, New Haven, CT (T.E.C.); and Department of Clinical Genetics (H.B.) and Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W.), Academic Medical Center, University of Amsterdam, The Netherlands.
Michael J AckermanFrom the Mayo Clinic School of Medicine (J.D.K., M.J.A.), Medical Scientist Training Program (J.D.K., M.J.A.), Mayo Clinic Graduate School of Biomedical Sciences, Department of Molecular Pharmacology and Experimental Therapeutics, Windland Smith Rice Sudden Death Genomics Laboratory (J.D.K., D.J.T., M.J.A.), Division of Biomedical Statistics and Informatics, Department of Health Sciences Research (N.B.L.), Division of Heart Rhythm Services, Department of Cardiovascular Diseases (D.J.T., M.J.A.), and Division of Pediatric Cardiology, Department of Pediatrics (M.J.A.), Mayo Clinic, Rochester, MN; Department of Medicine, Stanford University, Stanford, CA (K.N.P.); Transgenomic Inc, New Haven, CT (T.E.C.); and Department of Clinical Genetics (H.B.) and Heart Centre, Department of Clinical and Experimental Cardiology (A.A.M.W.), Academic Medical Center, University of Amsterdam, The Netherlands. ackerman.michael@mayo.edu.
Transgenomic (United States) · USStanford University · USMayo Clinic in Arizona · US

Funding

Cardiac Channel Mutations in Sudden Infant Death Syndrome (SIDS)R01HD042569 · NICHD · MAYO CLINIC ROCHESTER · PI ACKERMAN, MICHAEL JOHN · 2002 to 2017
$6.9M
Predoctoral Training Program in Molecular PharmacologyT32GM072474 · NIGMS · MAYO CLINIC ROCHESTER · PI KARNITZ, LARRY M · 2005 to 2020
$2.4M
NICHD NIH HHS R01 HD042569NIGMS NIH HHS T32 GM072474
6 · The paper itself

Abstract

backgroundPathogenic

methodsFrequency and location comparisons were made for

resultsA total of 18.2% (218/1200) of patients referred for commercial testing hosted rare

conclusionsCurrent expert recommendations have resulted in increased use of

Indexed as

Ryanodine Receptor Calcium Release ChannelTachycardia, VentricularExomeGenetic TestingGenetic VariationGenotypeHumansMutationPhenotypePolymorphic Catecholaminergic Ventricular TachycardiaRyanodine Receptor Calcium Release ChannelRyR2 protein, humancardiologistexonsgenetic testingphenotypeuncertainty

Identifiers

PMID29453246
PMCPMC6364978
OpenAlexW2788069694

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.