ArticleVirology2018
Antigenic and genetic evolution of contemporary swine H1 influenza viruses in the United States.
Article in Virology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers.
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Who cites it
48 citing papers in PubMed.
- Detection of Highly Pathogenic Avian Influenza A(H5N1) Clade 2.3.4.4b Genotype D1.2 Virus in Swine after Experimental Inoculation.Emerging infectious diseases · 2026Article
- Impact of maternal antibodies and weaning stress on the replication and transmission of human H3N2 influenza A in piglets.Journal of virology · 2026Article
- Sources and sinks of influenza A virus genomic diversity in swine from 2009 to 2022 in the United States.Journal of virology · 2025Article
- Article
- Passage of human-origin influenza A virus in swine tracheal epithelial cells selects for adaptive mutations in the hemagglutinin gene.PloS one · 2025Article
- Macroepidemiological trends of Influenza A virus detection through reverse transcription real-time polymerase chain reaction (RT-rtPCR) in porcine samples in the United States over the last 20 years.Frontiers in veterinary science · 2025Article
- Genomic diversity and evolutionary dynamics of Influenza A viruses in Colombian swine: implications for one health surveillance and control.Emerging microbes & infections · 2024Article
- Article
- Genetic drift and purifying selection shape within-host influenza A virus populations during natural swine infections.PLoS pathogens · 2024Article
- PARNAS: Objectively Selecting the Most Representative Taxa on a Phylogeny.Systematic biology · 2023Article
- Genetic drift and purifying selection shape within-host influenza A virus populations during natural swine infections.bioRxiv : the preprint server for biology · 2023Article
- From Snoot to Tail: A Brief Review of Influenza Virus Infection and Immunity in Pigs.Journal of immunology (Baltimore, Md. : 1950) · 2023Review
- Long-Term Epidemiology and Evolution of Swine Influenza Viruses, Vietnam.Emerging infectious diseases · 2023Article
- Article
- Testing for genetic mutation of seasonal influenza virus.Journal of applied statistics · 2023Article
- Veterinarian perceptions and practices in prevention and control of influenza virus in the Midwest United States swine farms.Frontiers in veterinary science · 2023Article
- Heterologous prime-boost H1N1 vaccination exacerbates disease following challenge with a mismatched H1N2 influenza virus in the swine model.Frontiers in immunology · 2023Article
- Characterizing a century of genetic diversity and contemporary antigenic diversity of N1 neuraminidase in influenza A virus from North American swine.Virus evolution · 2023Article
- A Bivalent Live Attenuated Influenza Virus Vaccine Protects against Drifted H1N2 and H3N2 Clinical Isolates in Swine.Viruses · 2022Article
- Antigenic Characterization and Pandemic Risk Assessment of North American H1 Influenza A Viruses Circulating in Swine.Microbiology spectrum · 2022Article
Corrections and comments
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Authors and funding
6 authors.
Funding
Abstract
Several lineages of influenza A viruses (IAV) currently circulate in North American pigs. Genetic diversity is further increased by transmission of IAV between swine and humans and subsequent evolution. Here, we characterized the genetic and antigenic evolution of contemporary swine H1N1 and H1N2 viruses representing clusters H1-α (1A.1), H1-β (1A.2), H1pdm (1A.3.3.2), H1-γ (1A.3.3.3), H1-δ1 (1B.2.2), and H1-δ2 (1B.2.1) currently circulating in pigs in the United States. The δ1-viruses diversified into two new genetic clades, H1-δ1a (1B.2.2.1) and H1-δ1b (1B.2.2.2), which were also antigenically distinct from the earlier H1-δ1-viruses. Further characterization revealed that a few key amino acid changes were associated with antigenic divergence in these groups. The continued genetic and antigenic evolution of contemporary H1 viruses might lead to loss of vaccine cross-protection that could lead to significant economic impact to the swine industry, and represents a challenge to public health initiatives that attempt to minimize swine-to-human IAV transmission.
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