Evidence map›Paper›PMID 29452963›Full record

ReviewCurrent opinion in immunology2018

Chemical sensing in development and function of intestinal lymphocytes.

Luisa Cervantes-Barragan, Marco Colonna

Open access · greenAbstract readReview
In one paragraph

Review in Current opinion in immunology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.8field-weighted citation impact, top 31% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Neuroimmune recognition and regulation in the respiratory system.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  2. Review
  3. Article
  4. Article
  5. Frontiers in pediatrics · 2019
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Luisa Cervantes-BarraganDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.
Marco ColonnaDepartment of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA. Electronic address: mcolonna@wustl.edu.
Washington University in St. Louis · US

Funding

Mucosal Immune Defense Mechanisms of the Urinary BladderU01AI095542 · NIAID · WASHINGTON UNIVERSITY · PI COLONNA, MARCO, HULTGREN, SCOTT J. · 2011 to 2020
$9.8M
CRTAM-CADM1 INTERACTION IN THE BIOLOGY OF GUT LYMPHOCYTESR01DK103039 · NIDDK · WASHINGTON UNIVERSITY · PI COLONNA, MARCO · 2015 to 2018
$1.4M
NIAID NIH HHS U01 AI095542NIDDK NIH HHS R01 DK103039
6 · The paper itself

Abstract

The immune system of the intestinal tract has the challenging task of recognizing and eliminating intestinal pathogens while maintaining tolerance to dietary and commensal antigens; therefore, it must be able to sense environmental cues within the intestine and mount suitable responses dictated by their pathogenic or nonpathogenic nature. The aryl hydrocarbon receptor (AHR) was originally characterized as a chemical sensor of the environmental pollutant 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) [12]. More recently, AHR has emerged as a major chemical sensor expressed in many intestinal immune cells that enables them to distinguish nutritional and microbial cues and is, therefore, important for development, maintenance and function of the intestinal immune system. In this review, we will highlight recent advances in our knowledge of the role of AHR signaling in intestinal innate lymphoid cells (ILC), T cells and B cells.

Indexed as

AnimalsB-LymphocytesCell DifferentiationHumansImmunity, InnateLigandsMucosal-Associated Invariant T CellsReceptors, Aryl HydrocarbonSignal TransductionLigandsReceptors, Aryl Hydrocarbon

Identifiers

PMID29452963
PMCPMC7456567
OpenAlexW2792488474

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.