Evidence map›Paper›PMID 29452950›Full record

ReviewTrends in microbiology2018

Dynamic Fungal Cell Wall Architecture in Stress Adaptation and Immune Evasion.

Alex Hopke, Alistair J P Brown, Rebecca A Hall, Robert T Wheeler

Abstract readReview
In one paragraph

Review in Trends in microbiology, 2018. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 121 papers.

0numbers the graph read from it
0cells of the map it votes in
121citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

121 citing papers in PubMed.

  1. Trial
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  4. Review
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  8. Compromising UDP-sugar nucleotide biosynthesis attenuatesCell surface (Amsterdam, Netherlands) · 2026
    Article
  9. Article
  10. Article
  11. UnderstandingJournal of medical microbiology · 2026
    Review
  12. Article
  13. Review
  14. Review
  15. Review
  16. Transient acceleration ofFrontiers in microbiology · 2026
    Article
  17. Article
  18. Review
  19. Article
  20. Article

61 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors.

Alex HopkeMolecular & Biomedical Sciences, University of Maine, Orono, ME, USA; Current address: BioMEMS Resource Center, Division of Surgery, Innovation and Bioengineering, Department of Surgery, Massachusetts General Hospital, Shriners Burns Hospital, Harvard Medical School, Charlestown, MA, USA.
Alistair J P BrownMRC Centre for Medical Mycology, Institute of Medical Sciences, University of Aberdeen, Foresterhill, Aberdeen, UK.
Rebecca A HallInstitute of Microbiology and Infection, and School of Biosciences, University of Birmingham, Edgbaston, Birmingham, UK.
Robert T WheelerMolecular & Biomedical Sciences, University of Maine, Orono, ME, USA; Graduate School of Biomedical Sciences and Engineering, University of Maine, Orono, ME, USA. Electronic address: robert.wheeler1@maine.edu.

Funding

Intravital study of innate immunity to mucosal candidiasisR15AI133415 · NIAID · UNIVERSITY OF MAINE ORONO · PI WHEELER, ROBERT T. · 2018 to 2018
$415k
Biotechnology and Biological Sciences Research Council BB/K017365/1Medical Research Council MR/L00903X/1Medical Research Council MR/M026663/1NIAID NIH HHS R15 AI133415Wellcome Trust 097377
6 · The paper itself

Abstract

Deadly infections from opportunistic fungi have risen in frequency, largely because of the at-risk immunocompromised population created by advances in modern medicine and the HIV/AIDS pandemic. This review focuses on dynamics of the fungal polysaccharide cell wall, which plays an outsized role in fungal pathogenesis and therapy because it acts as both an environmental barrier and as the major interface with the host immune system. Human fungal pathogens use architectural strategies to mask epitopes from the host and prevent immune surveillance, and recent work elucidates how biotic and abiotic stresses present during infection can either block or enhance masking. The signaling components implicated in regulating fungal immune recognition can teach us how cell wall dynamics are controlled, and represent potential targets for interventions designed to boost or dampen immunity.

Indexed as

Adaptation, PhysiologicalImmune EvasionCell WallEpitopesFungal ProteinsFungiGlucansHost-Pathogen InteractionsHumansHydrogen-Ion ConcentrationImmunity, InnateLactic AcidMycosesPolysaccharidesEpitopesFungal ProteinsGlucansLactic AcidPolysaccharidescell wallevasionfungiglucaninnate immunity

Identifiers

PMID29452950
PMCPMC5869159

What OpenQuestion holds

Textmetadata
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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.